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RXFP2

Official Full Name

relaxin/insulin-like family peptide receptor 2
Overview

This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms

RXFP2; relaxin/insulin-like family peptide receptor 2; leucine rich repeat containing G protein coupled receptor 8 , LGR8; relaxin receptor 2; GPR106; GREAT; INSL3R; RXFPR2; G protein coupled receptor 106; G protein coupled receptor affecting testicular descent; Leucine rich repeat containing G protein coupled receptor 8; LGR8; Relaxin family peptide receptor 2; RXFP 2; OTTHUMP00000018219; G-protein coupled receptor 106; G-protein coupled receptor affecting testicular descent; leucine-rich repeat-containing G protein-coupled receptor 8; leucine-rich repeat-containing G-protein coupled receptor 8; LGR8.1;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Canis lupus familiaris (Dog) (Canis familiaris)
Homo sapiens (Human)
Human
Mouse
Mus musculus (Mouse)
Rhesus Macaque

Source

E.coli expression system
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RXFP2-2099HCL	Recombinant Human RXFP2 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	RXFP2-14600M	Recombinant Mouse RXFP2 Protein	Mammalian Cell	His		Inquiry
Mouse	RXFP2-7860M	Recombinant Mouse RXFP2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	RXFP2-7860M-B	Recombinant Mouse RXFP2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Canis lupus familiaris (Dog) (Canis familiaris)	RFL26745CF	Recombinant Full Length Dog Relaxin Receptor 2(Rxfp2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-737)	Inquiry
Homo sapiens (Human)	RFL36821HF	Recombinant Full Length Human Relaxin Receptor 2(Rxfp2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-754)	Inquiry
Mus musculus (Mouse)	RFL15168MF	Recombinant Full Length Mouse Relaxin Receptor 2(Rxfp2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-737)	Inquiry
Rhesus Macaque	RXFP2-4060R	Recombinant Rhesus monkey RXFP2 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	RXFP2-3877R-B	Recombinant Rhesus Macaque RXFP2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	RXFP2-3877R	Recombinant Rhesus Macaque RXFP2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
RXFP2 Related Articles
RXFP2 Related Research Area

RXFP2 involved in several pathways and played different roles in them. We selected most pathways RXFP2 participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RXFP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)	ADRA2C;RLN3A;ACKR4;GPR17;OXGR1A.2;AGTR2;ADORA2A;UTS2D;S1PR3
G alpha (s) signalling events	POMCB;CGA;GCGB;RLN2;RAMP1;PTHLH;CRH;PDE10A;VIP2
GPCR downstream signaling	ARHGEF18;RXFP2;CNR2;OXGR1A.3;OXER1;PNOC;FPR-RS4;PROK1;AGTR2
GPCR ligand binding	PTHRP2;OXGR1A.2;GPR55A;ADORA2A;PRLH;RCA2.1;GPR55;OXGR1;ADORA3
Myometrial Relaxation and Contraction Pathways	RXFP2;GUCA2A;RGS16;MYLK2;ACTA1;GABPB1;CRH;RAMP1;RGS4
Neuroactive ligand-receptor interaction	GPR50;GRIN1A;TAAR2;GABBR1;ADORA2AB;PTGER2;GRIK5;CHRNA2A;OPRD1B
Peptide ligand-binding receptors	NPSR1;PROKR1;QRFPR;PPY;CCL35.2;NMB;EDN3;NTS;TAC3
Relaxin receptors	RLN3;RLN3A;RXFP2;INSL3;RLN2;INSL5

RXFP2 has several biochemical functions, for example, peptide hormone binding, protein-hormone receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RXFP2 itself. We selected most functions RXFP2 had, and list some proteins which have the same functions with RXFP2. You can find most of the proteins on our site.

Function	Related Protein
peptide hormone binding	PTH1RA;PTH1RB;PRLR;AGTR1B;GHRHR;GALR2;PTH1R;CRHR2;NPR2
protein-hormone receptor activity	GNRHR3;GNRHR2;RXFP2;GNRHR4;LGR4;GNRHR1

RXFP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RXFP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RXFP2.

Fenichel, P; Lahlou, N; et al. Cord blood Insulin-like peptide 3 (INSL3) but not testosterone is reduced in idiopathic cryptorchidism. CLINICAL ENDOCRINOLOGY 82:242-247(2015).

Nair, VB; Bathgate, RAD; et al. Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability. Biomed Research International :-(2015).

Peptide Hormone G Protein-Coupled Receptors