S100A1
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Official Full Name
S100 calcium binding protein A1 -
Overview
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. -
Synonyms
S100A1;S100 calcium binding protein A1;S100;S100A;S100-alpha;S100 calcium-binding protein A1;Protein S100-A1;S-100 protein subunit alpha;OTTHUMP00000035100;S-100 protein alpha chain;S100 alpha;S100 protein, alpha polypeptide
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- Cattle
- Chicken
- E.coli
- HEK293
- Mammalian Cells
- Human Cells
- Non
- GST
- Fc
- His
- MBP
- S
- DDK
- Myc
- Avi
- SUMO
- Flag
Involved Pathway
S100A1 involved in several pathways and played different roles in them. We selected most pathways S100A1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with S100A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
S100A1 has several biochemical functions, for example, ATPase binding,S100 protein binding,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by S100A1 itself. We selected most functions S100A1 had, and list some proteins which have the same functions with S100A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | UBE4A,MYO5A,PCDH10,TPO,BGLAP,CANT1B,HPCAL1,NINL,PKD1L3,CDK5R1 |
| protein homodimerization activity | TCF12,NPM1,SEPT12,SMAD2,GPD1B,NLGN4X,IRAK2,TGFB2,ERN1,VEGFB |
| identical protein binding | NISCH,TRIP10,FHOD1,DDX58,GPSM2,LRRK1,BCHE,ALDOB,WRNIP1,DPP9 |
| S100 protein binding | AGER,EZR,KCNK3,FGF1,ANXA11,ANXA2,S100A6,DDX1,S100B,FGF1A |
| ATPase binding | ATXN3,TCIRG1,ATPIF1A,NR1H2,FBL,ATP6V0A2B,FXYD3,SNX10,EZR,PGR |
| protein binding | HSCB,SORBS3,DMC1,SNX10,DPP3,VSIG4,TRIM50,TWSG1,HIST4H4,ICAM5 |
| calcium-dependent protein binding | CCDC167,MMP13,PDCD6,RAC3,CD209A,TNNT3,SELP,VLDLR,KCNIP3,ANXA2 |
Interacting Protein
S100A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S100A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of S100A1.
S100B;S100P
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References
- Diaz-Romero, J; Quintin, A; et al. S100A1 and S100B Expression Patterns Identify Differentiation Status of Human Articular Chondrocytes. JOURNAL OF CELLULAR PHYSIOLOGY 229:1106-1117(2014).
- Rohde, D; Schon, C; et al. S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll-like receptor 4. EMBO MOLECULAR MEDICINE 6:778-794(2014).
