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SAP130

Official Full Name

Sin3A-associated protein, 130kDa
Overview

SAP130 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex;(Fleischer et al., 2003 (PubMed 12724404)).
Synonyms

SAP130; Sin3A-associated protein, 130kDa; sin3A associated protein, 130kDa; histone deacetylase complex subunit SAP130; FLJ12761; mSin3A-associated protein 130; Sin3-associated polypeptide p130; 130 kDa Sin3-associated polypeptide;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Yeast

Tag

His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SAP130-2508H	Recombinant Human SAP130, His-tagged	E.coli	His	C-term-340aa	$319 / 25ug
Mouse	Sap130-23M	Recombinant Mouse Sap130 Protein, His-tagged	E.coli	His		Inquiry
Mouse	SAP130-14666M	Recombinant Mouse SAP130 Protein	Mammalian Cell	His		Inquiry
Mouse	SAP130-1888M	Recombinant Mouse SAP130 Protein (845-1057 aa), His-tagged	E.coli	His	845-1057 aa	Inquiry
Mouse	SAP130-1948M	Recombinant Mouse SAP130 Protein (845-1057 aa), His-tagged	Yeast	His	845-1057 aa	Inquiry
Mouse	SAP130-7897M	Recombinant Mouse SAP130 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	SAP130-7897M-B	Recombinant Mouse SAP130 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	SAP130-2957C	Recombinant Chicken SAP130	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

SAP130 involved in several pathways and played different roles in them. We selected most pathways SAP130 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation of gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with SAP130 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chromatin modifying enzymes	PADI4;SAP30L;ING5;ARID1A;COPRS;SMARCC2;PBRM1;KDM5A;ATXN7L3
Chromatin organization	PADI6;ANO9A;KAT8;PRMT7;MTA2;MBD3A;KDM5BB;SMARCD3B;VPS72
Epigenetic regulation of gene expression	TET2;EED;TET3;SAP30;CD3EAP;SAP30BP;SUZ12B;DNMT1;UHRF1
Gene Expression	PUS1;CD2BP2;ALKBH8;ZNF446;ZNF565;CDK8;TYW5;MED23;TAF1A
HATs acetylate histones	MSL2B;PAX3A;ENY2;KANSL2;ATXN7;KAT7A;TADA2A;SAP130;ELP2
Negative epigenetic regulation of rRNA expression	TAF1B;SIN3B;EFCAB11;SAP30BP;DNMT3B;BAZ2A;TAF1A;SAP130;SAP30
NoRC negatively regulates rRNA expression	SAP30BP;TAF1C;DNMT3B;SUDS3;EFCAB11;TAF1B;SAP30L;DNMT1;SAP130

SAP130 has several biochemical functions, for example, contributes_to histone acetyltransferase activity, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SAP130 itself. We selected most functions SAP130 had, and list some proteins which have the same functions with SAP130. You can find most of the proteins on our site.

Function	Related Protein
contributes_to histone acetyltransferase activity	SUPT7L;TAF9;TADA2A;EPC1;ELP4;TEX30;KAT2A;TAF6L;TAF10
transcription coactivator activity	CITED1;SUPT7L;CBFB;HCFC1;NFE2;ABRA;ECD;RBPMS;MED6

SAP130 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SAP130 here. Most of them are supplied by our site. Hope this information will be useful for your research of SAP130.

SMAD3; Max; mdm2_human_probe; SIN3B; KIF20A; HDAC1; Sap25; Tet1; HDAC2; TPX2