SAP30
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Official Full Name
Sin3A-associated protein, 30kDa
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Overview
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. -
Synonyms
SAP30; Sin3A-associated protein, 30kDa; sin3A associated protein, 30kDa; histone deacetylase complex subunit SAP30; sin3-associated polypeptide p30; 30 kDa Sin3-associated polypeptide; Sin3-associated polypeptide, 30kDa; sin3-associated polypeptide, 30 kDa; Sin3 corepressor complex subunit SAP30;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | SAP30-1559HCL | Recombinant Human SAP30 cell lysate | N/A | |||
Human | SAP30-3031H | Recombinant Human SAP30 protein, His-tagged | E.coli | His | 68 - 197 aa | |
Mouse | SAP30-14669M | Recombinant Mouse SAP30 Protein | Mammalian Cell | His | ||
Mouse | SAP30-7899M | Recombinant Mouse SAP30 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | SAP30-7899M-B | Recombinant Mouse SAP30 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | SAP30-4072R | Recombinant Rhesus monkey SAP30 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | SAP30-3889R | Recombinant Rhesus Macaque SAP30 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | SAP30-3889R-B | Recombinant Rhesus Macaque SAP30 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
- SAP30 Related Signal Pathway
SAP30 involved in several pathways and played different roles in them. We selected most pathways SAP30 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SAP30 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Chromatin modifying enzymes | KDM5B;MBD3;MBIP;KIAA1267;CHD4A;PRDM16;SMYD2;GATAD2B;ELP2 |
Chromatin organization | AEBP2;ING3;KDM6B;MBD3;SMARCB1A;EHMT2;MBIP;KDM6AL;PADI1 |
Delta-Notch Signaling Pathway | ASCL1;YY1A;HEY2;ASCL1A;MAGEA1;JAG1;CNTF;HIVEP3;JAG2 |
Epigenetic regulation of gene expression | PHF19;DNMT3B;JARID2B;SUDS3;SAP30;SUZ12;SAP30L;SMARCA5;JARID2 |
Gene Expression | COX7C;RXRBB;POLR3H;ZNF45;ZNF549;GATAD2A;SNAPC5;ZNF669;NRBF2 |
HDACs deacetylate histones | BRMS1;KDM1A;ANO9A;GATAD2B;CHD4A;GATAD2AB;SAP30L;CHD4;MTA2 |
Hedgehog signaling events mediated by Gli proteins | CSNK1G3;SPOP;MTSS1;KIF3A;SIN3B;SAP18;CSNK1G2;IFT88;SAP30 |
Negative epigenetic regulation of rRNA expression | SAP18;CD3EAP;BAZ2A;TAF1B;DNMT1;SUDS3;SAP30BP;DNMT3B;EFCAB11 |
SAP30 has several biochemical functions, for example, DNA binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SAP30 itself. We selected most functions SAP30 had, and list some proteins which have the same functions with SAP30. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | IRX4B;E2F4;ZNF234;PRDM4;RCOR1;EPAS1B;ZFP423;SPTY2D1;TBX2B |
metal ion binding | ZNF512;ACSM3;TRIM27;ZNF485;TUT1;ZSCAN23;RBM26;TRIM35-39;ZFAND5A |
protein binding | SFTPD;TIMELESS;APOBEC3C;IL24;REEP1;ARMC7;KCNH2;MARCH10;EGLN3 |
transcription corepressor activity | KCNA3;HOMEZA;CRYM;EID1;SNW1;SAP30;SKOR1B;PROX1;HEYL |
SAP30 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SAP30 here. Most of them are supplied by our site. Hope this information will be useful for your research of SAP30.
HDAC1; HDAC2; SIN3A; NCOR2; CIR1; Max; BRMS1; SAP130; TNRC18; SIN3B; SIN3B; ARID4A; FOXK1; FOXK2; SMC1A
- Q&As
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