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SAP30

  • Official Full Name

    Sin3A-associated protein, 30kDa

  • Overview

    Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3.
  • Synonyms

    SAP30; Sin3A-associated protein, 30kDa; sin3A associated protein, 30kDa; histone deacetylase complex subunit SAP30; sin3-associated polypeptide p30; 30 kDa Sin3-associated polypeptide; Sin3-associated polypeptide, 30kDa; sin3-associated polypeptide, 30 kDa; Sin3 corepressor complex subunit SAP30;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SAP30-1559HCL Recombinant Human SAP30 cell lysate N/A
Human SAP30-3031H Recombinant Human SAP30 protein, His-tagged E.coli His 68 - 197 aa
Mouse SAP30-14669M Recombinant Mouse SAP30 Protein Mammalian Cell His
Mouse SAP30-7899M Recombinant Mouse SAP30 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SAP30-7899M-B Recombinant Mouse SAP30 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SAP30-4072R Recombinant Rhesus monkey SAP30 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SAP30-3889R Recombinant Rhesus Macaque SAP30 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SAP30-3889R-B Recombinant Rhesus Macaque SAP30 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SAP30 Related Signal Pathway

SAP30 involved in several pathways and played different roles in them. We selected most pathways SAP30 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SAP30 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chromatin modifying enzymesKDM5B;MBD3;MBIP;KIAA1267;CHD4A;PRDM16;SMYD2;GATAD2B;ELP2
Chromatin organizationAEBP2;ING3;KDM6B;MBD3;SMARCB1A;EHMT2;MBIP;KDM6AL;PADI1
Delta-Notch Signaling PathwayASCL1;YY1A;HEY2;ASCL1A;MAGEA1;JAG1;CNTF;HIVEP3;JAG2
Epigenetic regulation of gene expressionPHF19;DNMT3B;JARID2B;SUDS3;SAP30;SUZ12;SAP30L;SMARCA5;JARID2
Gene ExpressionCOX7C;RXRBB;POLR3H;ZNF45;ZNF549;GATAD2A;SNAPC5;ZNF669;NRBF2
HDACs deacetylate histonesBRMS1;KDM1A;ANO9A;GATAD2B;CHD4A;GATAD2AB;SAP30L;CHD4;MTA2
Hedgehog signaling events mediated by Gli proteinsCSNK1G3;SPOP;MTSS1;KIF3A;SIN3B;SAP18;CSNK1G2;IFT88;SAP30
Negative epigenetic regulation of rRNA expressionSAP18;CD3EAP;BAZ2A;TAF1B;DNMT1;SUDS3;SAP30BP;DNMT3B;EFCAB11

SAP30 has several biochemical functions, for example, DNA binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SAP30 itself. We selected most functions SAP30 had, and list some proteins which have the same functions with SAP30. You can find most of the proteins on our site.

Function Related Protein
DNA bindingIRX4B;E2F4;ZNF234;PRDM4;RCOR1;EPAS1B;ZFP423;SPTY2D1;TBX2B
metal ion bindingZNF512;ACSM3;TRIM27;ZNF485;TUT1;ZSCAN23;RBM26;TRIM35-39;ZFAND5A
protein bindingSFTPD;TIMELESS;APOBEC3C;IL24;REEP1;ARMC7;KCNH2;MARCH10;EGLN3
transcription corepressor activityKCNA3;HOMEZA;CRYM;EID1;SNW1;SAP30;SKOR1B;PROX1;HEYL

SAP30 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SAP30 here. Most of them are supplied by our site. Hope this information will be useful for your research of SAP30.

HDAC1; HDAC2; SIN3A; NCOR2; CIR1; Max; BRMS1; SAP130; TNRC18; SIN3B; SIN3B; ARID4A; FOXK1; FOXK2; SMC1A

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