SDHA
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Official Full Name
succinate dehydrogenase complex, subunit A, flavoprotein (Fp) -
Overview
Succinate dehydrogenase (SDH), also known as Complex II or succinate:quinone oxidoreductase, is a key component of the citric acid cycle and the electron transport chain. Specifically, it is involved in the oxidation of succinate. SDH consists of four sub -
Synonyms
SDHA;succinate dehydrogenase complex, subunit A, flavoprotein (Fp);SDH2;succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial;FP;SDHF;flavoprotein subunit of complex II;succinate dehydrogenase complex flavoprotein subunit;PGL5
Recombinant Proteins
- Bacillus subtilis
- Zebrafish
- Human
- Mouse
- Chicken
- Rat
- E.Coli/Yeast
- Mammalian Cells
- E.coli
- HEK293
- His
- SUMO
- GST
- Non
- T7
- Avi
- Fc
Involved Pathway
SDHA involved in several pathways and played different roles in them. We selected most pathways SDHA participated on our site, such as Citrate cycle (TCA cycle),Oxidative phosphorylation,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SDHA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-alcoholic fatty liver disease (NAFLD) | COX6A2,COX7A2,PIK3R2,PIK3R3,NDUFB11,TNF,NDUFS6,NDUFV3,INS1,NDUFB5 |
| Parkinsons disease | ATP5E,NDUFA9,ATP5D,SNCA,NDUFA11,NDUFV2,COX7B,MT-ATP6,SDHD,UQCRQ |
| Citrate cycle (TCA cycle) | OGDHL,SDHDA,ACO2,OGDHA,PDHA1,PDHB,PDHA1B,PCK2,PC,IDH1 |
| Metabolic pathways | IL4I1,ALG12,GGPS1,CYP4A12A,MTMR1A,POLR1C,SEPHS1,UPB1,LIPCA,ackA |
| Huntingtons disease | UQCRC1,ATP5C1,DNAHC8,GRIN2B,NDUFS2,NDUFAB1,COX7A2,PPARG,POLR2D,COX8A |
| Oxidative phosphorylation | ATP6V0A1A,SDHD,ATP5IA,NDUFB5,ATP6V0E1,ATP5F1,ATP6V0D1,ATP5IB,ATP6V0E,NDUFB9 |
| Alzheimers disease | NDUFB9,AKR1C1,NDUFS6,PLCB1,NDUFC2-KCTD14,MT-ATP6,APOE,ATP2A2,NDUFA2,CASP12 |
| Carbon metabolism | PGLS,G6PDX,ENO3,PKMB,PDHA1B,GLUD1B,ACADM,GPR19,GPT2,ECHS1 |
Protein Function
SDHA has several biochemical functions, for example, flavin adenine dinucleotide binding,protein binding,succinate dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SDHA itself. We selected most functions SDHA had, and list some proteins which have the same functions with SDHA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| succinate dehydrogenase activity | SDHD |
| protein binding | RGS8,PPP1R12A,BSCL2,KIAA1609,SLC41A3,ATG12,CHN1,PSMD5,TSHZ3,MUL1 |
| contributes_to succinate dehydrogenase activity | SDHDA,SDHDB |
| succinate dehydrogenase (ubiquinone) activity | SDHB |
| flavin adenine dinucleotide binding | IVD,ACOXL,CYB5R3,NOS1,FOXRED2,PPOX,ETFDH,ACAD8,DLD,AIFM4 |
Interacting Protein
SDHA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SDHA here. Most of them are supplied by our site. Hope this information will be useful for your research of SDHA.
SDHB;HLA-B;IKBKE;FXN;CSNK2B;q5ni74_fratt;rcsC;lysS;15-deoxy-delta(12,14;GABARAP;MYC;nef;SLC25A5;VCAM1;ARRB2;GABARAPL2;CLPP
Resources
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References
- Williamson, SR; Eble, JN; et al. Succinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinoma. MODERN PATHOLOGY 28:80-94(2015).
- Grimm, M; Cetindis, M; et al. Association of cancer metabolism-related proteins with oral carcinogenesis - indications for chemoprevention and metabolic sensitizing of oral squamous cell carcinoma?. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).
