SDHB
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Official Full Name
succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -
Overview
Flavoprotein subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). -
Synonyms
SDHB;succinate dehydrogenase complex, subunit B, iron sulfur (Ip);SDH, SDH1;succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial;iron-sulfur subunit of complex II;IP;SDH;PGL4;SDH1;SDH2;SDHIP;FLJ92337
Recombinant Proteins
- Bacillus subtilis
- Human
- Chicken
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- E.Coli/Yeast
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- T7
- Avi
- Fc
Involved Pathway
SDHB involved in several pathways and played different roles in them. We selected most pathways SDHB participated on our site, such as Citrate cycle (TCA cycle),Oxidative phosphorylation,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SDHB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Citrate cycle (TCA cycle) | IDH3A,MDH1,DLAT,PC,DLD,DLST,SUCLG1,PCK2,PDHA1B,ACLYA |
| Alzheimers disease | CDK5R1,NDUFS6,UQCRC2,UQCRQ,CASP8,UQCRB,ATP5E,CALM3,LRP1,NDUFA3 |
| Metabolic pathways | ACSS1,GDA,COX5AA,NME2B.2,ALDH9A1A.1,SPAM1,PNAT10,NDUFA7,INPP5K,CKBB |
| Oxidative phosphorylation | ATP6V1E1,UQCRC1,COX10,ATP6V0B,ATP4B,ATP5G3B,COX17,ATP6V1G1,NDUFB8,ATP5L |
| Huntingtons disease | NDUFS5,NDUFA4,VDAC1,Atp5g2,NDUFA12,COX5B,NDUFAB1,POLR2K,TBP,SLC25A5 |
| Parkinsons disease | NDUFV3,ATP5J,NDUFB4,GNAI1,ATP5D,NDUFB10,UBB,UQCR10,NDUFAB1,SLC25A31 |
| Carbon metabolism | PRPS1A,PSAT1,SDHC,HIBCH,MCEE,HAO1,ALDH6A1,FBP1B,FBP1,ENO1A |
| Non-alcoholic fatty liver disease (NAFLD) | COX6B2,PIK3CA,COX6A2,UQCRC1,CDC42,PRKAB1,CEBPA,NDUFA4L2,PIK3CB,NDUFA10 |
Protein Function
SDHB has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding,3 iron, 4 sulfur cluster binding,4 iron, 4 sulfur cluster binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SDHB itself. We selected most functions SDHB had, and list some proteins which have the same functions with SDHB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquinone binding | DHODH,SDHD,SDHDA,SDHDB,ETFDH |
| 4 iron, 4 sulfur cluster binding | DDX11,NUBP2,EXO5,DPYDB,NDUFS8B,ACO2,NUBP1,POLD1,DNA2,TYW1B |
| 2 iron, 2 sulfur cluster binding | CIAPIN1,AIFM3,GLRX2,AOX3,ISCUB,AIFM4,AOX3L1,ISCU,FDX1L,FECH |
| 3 iron, 4 sulfur cluster binding | ACO2 |
| electron carrier activity | GCDHA,NDUFA12,NCF2,NCF1,AOX3,ADH5,PTGES2,ETFB,GLRX3,SDHD |
| succinate dehydrogenase (ubiquinone) activity | SDHA |
| metal ion binding | SMYD2B,CYCS,ATF7,ZFP64,VEPH1,ZNF174,BTR18,ZFP518A,ARAP3,REV3L |
| protein binding | UQCC2,FAM3C,PATL1,HPS1,TEX10,OSTC,PGM1,CYC1,ARVCF,RPS13 |
Interacting Protein
SDHB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SDHB here. Most of them are supplied by our site. Hope this information will be useful for your research of SDHB.
MCC;SDHA;IKBKE;FXN;SPRY2;GEM;PIK3R5;GABARAP;SLC25A5;VCAM1;GABARAPL1;SPNS1
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References
- Moch, H; Montironi, R; et al. Oncotargets in Different Renal Cancer Subtypes. CURRENT DRUG TARGETS 16:125-135(2015).
- Elston, MS; Meyer-Rochow, GY; et al. Increased SSTR2A and SSTR3 expression in succinate dehydrogenase-deficient pheochromocytomas and paragangliomas. HUMAN PATHOLOGY 46:390-396(2015).
