sdhb
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  • Official Full Name
  • succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
  • Background
  • Flavoprotein subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
  • Synonyms
  • SDHB; succinate dehydrogenase complex, subunit B, iron sulfur (Ip); SDH, SDH1; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; iron-sulfur subunit of complex II; IP; SDH; PGL4; SDH1; SDH2; SDHIP; FLJ92337
Cat.#:SDHB-140HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SDHB Protein, His-tagged
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Cat.#:SDHB-31392THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SDHB, His-tagged
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Cat.#:SDHB-369HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human SDHB
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Cat.#:Sdhb-1710MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Sdhb protein, His & T7-tagged
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Cat.#:SDHB-5292RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SDHB Protein
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Cat.#:SDHB-4112RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SDHB Protein, His-tagged
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Cat.#:SDHB-3632CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SDHB
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Cat.#:SDHB-5321CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SDHB
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Cat.#:SDHB-5703ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SDHB
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Cat.#:SDHB-0472BTag:His
Source (Host):E. coli or YeastSpecies:Bacillus subtilis
Product nameRecombinant Bacillus subtilis SDHB protein, His-tagged
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Cat.#:SDHB-2009HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SDHB 293 Cell Lysate
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Involved Pathway

SDHB involved in several pathways and played different roles in them. We selected most pathways SDHB participated on our site, such as Citrate cycle (TCA cycle), Oxidative phosphorylation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with SDHB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Citrate cycle (TCA cycle)
PDHA1; IDH1; ACLYA; OGDH; FH; DLAT; PDHA2; DLST; PDHB; SDHC
Oxidative phosphorylation
ATP12A; ATP6AP1B; ATP5G3B; PPA1; NDUFS4; COX7A3; NDUFA8; ATP6V0D2; SDHD; ATP6V1G2
Metabolic pathways
PTGES3B; B4GALT3; PLCD1A; ybaS; CYP2C18; NDUFB10; ST8SIA5; HIBCH; CAD; CCBL1
Carbon metabolism
GOT1; CAT; ALDOB; MDH1AA; ENO1B; SDHB; GPIB; IDH3A; ACO2; CS
Non-alcoholic fatty liver disease (NAFLD)
NDUFB6; NDUFB2; PIK3CA; NDUFA12; COX7A2; BID; NDUFC2; COX6A2; CASP7; UQCRH
Alzheimers disease
PLCB4; NDUFV2; NDUFS1; SDHB; MME; SDHA; PPP3CB; COX7A2L; ADAM17; UQCR11
Parkinsons disease
UBE2J1; LRRK2; NDUFA9; SLC18A2; DRD1A; APAF1; SLC25A4; NDUFB9; NDUFA4L2; NDUFC2
Huntingtons disease
COX6A2; TRP53; GRIN2B; NDUFS8; mt-Atp8; COX6B2; CYCS; POLR2D; CASP9; ATP5H

Protein Function

SDHB has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding, 3 iron, 4 sulfur cluster binding, 4 iron, 4 sulfur cluster binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SDHB itself. We selected most functions SDHB had, and list some proteins which have the same functions with SDHB. You can find most of the proteins on our site.
Function
Related Protein
Function 2 iron, 2 sulfur cluster binding
Related Protein ISCUB; FDX1; AIFM3; CIAPIN1; ISCU; CMAH; UQCRFS1; AOX4; CISD3; XDH
Function 3 iron, 4 sulfur cluster binding
Related Protein SDHB; ACO2
Function 4 iron, 4 sulfur cluster binding
Related Protein NDUFS8; RSAD1; DNA2; DEM1; ACO2; PPAT; EXO5; SDHB; NDUFS2; IREB2
Function electron carrier activity
Related Protein GCDHB; ADH5; GLDC; NQO2; AKR7A3; CYP19A1; ACADM; ACAD11; GLRX2; ME2
Function metal ion binding
Related Protein ZNF689; UBR1; CYP2K22; YY1A; QTRT1; KDM6A; SMAD5; NT5C; ZFP667; MBLAC2
Function protein binding
Related Protein LUM; FAM207A; ITGA4; RGP1; MYH8; RASSF2; BRAP; EWSR1; APBB1IP; ROBO2
Function succinate dehydrogenase (ubiquinone) activity
Related Protein SDHA; SDHB
Function ubiquinone binding
Related Protein SDHDB; ETFDH; SDHD; DHODH; SDHB; SDHDA

Interacting Protein

SDHB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SDHB here. Most of them are supplied by our site. Hope this information will be useful for your research of SDHB.
MCC; SDHA; IKBKE; FXN; SPRY2; GEM; PIK3R5; GABARAP; SLC25A5; VCAM1; GABARAPL1; SPNS1

SDHB Related Articles

Elston, MS; Meyer-Rochow, GY; et al. Increased SSTR2A and SSTR3 expression in succinate dehydrogenase-deficient pheochromocytomas and paragangliomas. HUMAN PATHOLOGY 46:390-396(2015).
Moch, H; Montironi, R; et al. Oncotargets in Different Renal Cancer Subtypes. CURRENT DRUG TARGETS 16:125-135(2015).