Selplg

  • Official Full Name

    selectin P ligand

  • Overview

    This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
  • Synonyms

    SELPLG; selectin P ligand; CLA; CD162; PSGL1; PSGL-1; P-selectin glycoprotein ligand 1; cutaneous lymphocyte-associated associated antigen;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • 6×His
  • Fc
  • hFc
  • His
  • Fc Chimera
  • hIgG
  • Avi
  • His (Fc)
  • His|GST
  • His|T7
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SELPLG-420H Recombinant Human SELPLG, His tagged HEK293 His Met1-Gly295
Human SELPLG-93H Recombinant Human SELPLG protein, T7/His-tagged E.coli T7/His
Human SELPLG-834H Recombinant Human SELPLG protein(Met1-Val295), His&hFc-tagged HEK293 C-His&hFc Met1-Val295
Human SELPLG-242H Active Recombinant Human SELPLG Protein, Fc-tagged CHO Fc
Human SELPLG-5034H Recombinant Human SELPLG, His-tagged E.coli His
Human SELPLG-433H Recombinant Human selectin P ligand, His-tagged E.coli His
Human SELPLG-1089HCL Recombinant Human SELPLG cell lysate Human Cell N/A
Human SELPLG-560H Recombinant Human SELPLG Protein (Leu18-Cys320), C-6×His-tagged HEK293 C-6×His Leu18-Cys320
Human SELPLG-458H Recombinant Human SELPLG protein, hFc-tagged HEK293 hFc Leu18-Cys320
Human SELPLG-2049H Recombinant Human SELPLG Protein, His-tagged CHO N-His Ala25-Pro287
Human SELPLG-531H Recombinant Human SELPLG Protein, Fc-tagged HEK293 Fc Met1-Val295
Human SELPLG-129H Recombinant Human SELPLG Protein, C-His-tagged E.coli C-His
Human SELPLG-533H Active Recombinant Human SELPLG protein, His-tagged HEK293 His Gln 42 - Cys 320
Human SELPLG-03H Recombinant Human SELPLG Protein, hIgG/His-tagged HEK293 hIgG/His 42-295
Human SELPLG-1846H Recombinant Human SELPLG protein, His & Avi-tagged, Biotinylated HEK293 His & Avi Gln 42 - Cys 320
Human SELPLG-1006H Recombinant Human SELPLG protein, His & Avi-tagged HEK293 His & Avi Gln 42 - Cys 320
Human SELPLG-5087H Recombinant Human SELPLG Protein (Met1-Gly295), C-His tagged Mammalian cells C-His Met1-Gly295
Mouse Selplg-292M Active Recombinant Mouse Selplg, Fc Chimera CHO Fc Chimera
Mouse Selplg-1773M Recombinant Mouse Selectin, Platelet (P-selectin) Ligand Mammalian cells N/A
Mouse Selplg-528M Recombinant Mouse Selplg Human Cell N/A Met1-Cys307
Mouse Selplg-7020M Recombinant Mouse Selplg protein(Met1-Cys307), hFc-tagged HEK293 C-hFc Met1-Cys307
Mouse Selplg-125M Recombinant Mouse Selplg protein, His/GST-tagged E.coli His/GST Ser94~Ser345
Mouse SELPLG-001MCL Recombinant Mouse SELPLG cell lysate Human Cell N/A
Mouse Selplg-10613M Recombinant Mouse Selplg Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Selplg-10613M-B Recombinant Mouse Selplg Protein Pre-coupled Magnetic Beads HEK293
Mouse Selplg-5747M Recombinant Mouse Selplg Protein (Gln42-Cys307), C-Fc tagged Mammalian cells C-Fc Gln42-Cys307
Rat Selplg-5700R Recombinant Rat Selplg protein, His & T7-tagged E.coli His/T7 Ser132~Gly406 (Accession # Q8K5B0)
Zebrafish SELPLG-8221Z Recombinant Zebrafish SELPLG Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

Selplg involved in several pathways and played different roles in them. We selected most pathways Selplg participated on our site, such as Cell adhesion molecules (CAMs), Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with Selplg were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)CD40;CLDN17;CLDND;VTCN1;CADM1B;BF2;H2-AA;CDH1;CD28
Staphylococcus aureus infectionFCGR3A;HLA-DQA2;FCGR2C;FCGR1A;FPR2;HLA-DPB1;C4A;HLA-DRB4;Hc

Selplg has several biochemical functions, for example, protein binding, receptor binding, virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Selplg itself. We selected most functions Selplg had, and list some proteins which have the same functions with Selplg. You can find most of the proteins on our site.

Function Related Protein
protein bindingSYT4;SCARB2;TAF13;RNF10;TFCP2;OAS1;MPP6;TAG-260;NDUFB10
receptor bindingLEPROT;AMH;FZD1;ARPP19A;NRG3;ACOX2;DDO;ENSA;NRTN
virus receptor activitySCARB2;HTR2A;ACE2;SLC1A5;CR2;DPP4;TNFRSF14;HAVCR1;CD209

Selplg has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Selplg here. Most of them are supplied by our site. Hope this information will be useful for your research of Selplg.

SNX20; FLOT2; SELP; o68791_yerpe; sdhA; dcyD; ywdH

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