SEPT5

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SEPT5

Official Full Name septin 5
Background This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.
Synonyms SEPT5; septin 5; peanut like 1 (Drosophila) ; PNUTL1; septin-5; H5; HCDCREL 1; 5 Sep; CDCrel 1; CDCREL; CDCrel-1; CDCREL1; Cell division control related protein 1; Cell division control-related protein 1; H5; HCDCREL 1; OTTHUMP00000197271; OTTHUMP00000197272; OTTHUMP00000197273; OTTHUMP00000197274; OTTHUMP00000197275; OTTHUMP00000197276; OTTHUMP00000197396; OTTHUMP00000197410; Peanut like 1; Peanut like 1 homolog; Peanut like protein 1; Peanut-like protein 1; Platelet glycoprotein Ib beta chain; PNUTL1; SEPT5; SEPT5_HUMAN; Septin 5; Septin-5; peanut-like 1; platelet glycoprotein Ib beta chain; cell division control related protein 1; CDCREL; PNUTL1; CDCREL1; CDCREL-1; HCDCREL-1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SEPT5-1957HCL Recombinant Human SEPT5 293 Cell Lysate HEK293 N/A
    Human SEPT5-30597TH Recombinant Human SEPT5, HIS-tagged E.coli His
    Human SEPT5-30599TH Recombinant Human SEPT5, HIS-tagged E.coli His
    Human SEPT5-31398TH Recombinant Human SEPT5, HIS-tagged E.coli His
    Human SEPT5-356H Recombinant Human SEPT5 Protein, His-tagged E.coli His
    Human SEPT5-3591H Recombinant Human SEPT5, His-tagged E.coli His
    Human SEPT5-5249H Recombinant Human SEPT5 Protein, GST/His-tagged E.coli GST/His
    Mouse SEPT5-14895M Recombinant Mouse SEPT5 Protein Mammalian Cell His
    Rat SEPT5-5327R Recombinant Rat SEPT5 Protein Mammalian Cell His
    Chicken SEPT5-2360C Recombinant Chicken SEPT5 Mammalian Cell His

    SEPT5 involved in several pathways and played different roles in them. We selected most pathways SEPT5 participated on our site, such as Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEPT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Parkinsons disease NDUFB6; NDUFS6; mt-Atp8; ATP5J; GNAL; SDHC; NDUFA4L2; NDUFAB1; SDHD; NDUFV2

    SEPT5 has several biochemical functions, for example, GTP binding, GTPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEPT5 itself. We selected most functions SEPT5 had, and list some proteins which have the same functions with SEPT5. You can find most of the proteins on our site.

    Function Related Protein
    GTP binding GBP1; SEPT2; RAB31; HSP90AB1; GCH1; ARF4A; GTPBP3; RND3B; RAC1A; RAB33A
    GTPase activity RASEF; LGALS6; ARF3; EIF5; GNG11; RAB33B; DNM1B; IIGP1; RAN; EIF2S3Y
    protein binding FOXM1; RGS20; HNF1A; THAP6; CUL4A; PMF1; NUMBL; SETDB1; RAB1; RBP7
    structural molecule activity ODF2; KRT1-C5; CYT1L; KRT71; NGS; KRT82; CLDN11B; ISCA2; KRT222; CLDN18

    SEPT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEPT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SEPT5.

    SEPT11; SEPT10; SEPT6; SEPT2; SEPT1

    Zeraik, AE; Rinaldi, G; et al. Septins of Platyhelminths: Identification, Phylogeny, Expression and Localization among Developmental Stages of Schistosoma mansoni. PLOS NEGLECTED TROPICAL DISEASES 7:-(2013).
    Tsang, CW; Estey, MP; et al. Characterization of presynaptic septin complexes in mammalian hippocampal neurons. BIOLOGICAL CHEMISTRY 392:739-749(2011).

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