HTRA1
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Official Full Name
HtrA serine peptidase 1
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Overview
This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. -
Synonyms
HTRA1; HtrA serine peptidase 1; protease, serine, 11 (IGF binding) , PRSS11; serine protease HTRA1; HtrA; IGFBP5 protease; IGFBP5-protease; protease, serine, 11 (IGF binding); high-temperature requirement A serine peptidase 1; L56; ARMD7; ORF480; PRSS11;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- SUMO
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- HTRA1 Related Articles
- HTRA1 Related Research Area
HTRA1 involved in several pathways and played different roles in them. We selected most pathways HTRA1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HTRA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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HTRA1 has several biochemical functions, for example, insulin-like growth factor binding, serine-type endopeptidase activity, serine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HTRA1 itself. We selected most functions HTRA1 had, and list some proteins which have the same functions with HTRA1. You can find most of the proteins on our site.
Function | Related Protein |
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insulin-like growth factor binding | IGFBP2B;ESM1;KAZALD1;IGFBP6B;HTRA3A;HTRA1;IGFBP7;DEFB126;HTRA1B |
serine-type endopeptidase activity | PRSS3;PRSS1;TMPRSS13A;PARL;TMPRSS4B;KLK5;ELA2L;PROZ;KLK1B22 |
serine-type peptidase activity | F9B;KLK1B26;DPP7;GZMC;Gzmd;TPP1;KLK1B3;ST14;PRSS52 |
HTRA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTRA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HTRA1.
IMPDH1; NOS3; CSNK2B; FAM46A; yibD; GRB2; GOLT1B
- Q&As
- Reviews
Q&As (6)
Ask a questionThe structure of the HTRA1 protein determines its function. The serine protease domain is the main functional region of HTRA1 protein, which has catalytic activity and can degrade proteins. In addition, the HTRA1 protein has a number of different domains that are closely related to its function.
Therapeutic strategies for HTRA1 protein include inhibiting its activity, regulating its expression level, and altering its structure. Several drugs are already undergoing clinical trials to evaluate their efficacy against cancer and other diseases.
There are currently no treatments that directly regulate HTRA1 protein expression. However, some diseases can be treated by inhibiting their activity or regulating their expression levels. For example, some drugs can inhibit the activity of the HTRA1 protein to treat cancer or Alzheimer's disease.
HTRA1 protein can be used as a signal transduction molecule by binding to receptors on the cell surface to transmit signals to the cell interior and participate in cell proliferation, differentiation and apoptosis.
This protein can degrade a variety of proteins in the extracellular matrix, including collagen, elastin and fibrin, and thus participate in extracellular matrix remodeling.
The expression level of HTRA1 protein in biological samples can be detected by immunohistochemistry, western blot and real-time quantitative PCR.
Customer Reviews (3)
Write a reviewThe structure of HTRA1 is stable and not easy to mutate, which ensures the reliability of the experimental results.
The solubility and ion exchange capacity are very good, which is convenient for subsequent experimental processing and purification.
It is easy to operate and does not require complex operation steps.
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