SGK1 Protein

September 27-30, 2022

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Booth #336

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SGK1

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SGK1

Official Full Name serum/glucocorticoid regulated kinase 1
Background This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Synonyms SGK1; serum/glucocorticoid regulated kinase 1; serum/glucocorticoid regulated kinase , SGK; serine/threonine-protein kinase Sgk1; serine/threonine protein kinase SGK; serum/glucocorticoid-regulated kinase 1; SGK
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Hi-5 Insect Cell
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SGK1-3920H Recombinant Human SGK1 protein, His-tagged Insect Cell His
    Human SGK1-4993H Recombinant Human SGK1 protein, GST-tagged Insect Cell GST
    Human SGK1-1346H Recombinant Human Serum/Glucocorticoid Regulated Kinase 1, His-tagged Hi-5 Insect Cell His
    Human SGK1-30970TH Recombinant Human SGK1 N/A
    Human SGK1-428H Recombinant Human SGK1, GST-tagged, Active Sf9 Insect Cell GST
    Human SGK1-577H Recombinant Human SGK1, GST-tagged Sf9 Insect Cell GST
    Human SGK1-644H Recombinant Human SGK1, GST-tagged E.coli GST
    Human SGK1-755H Recombinant Human SGK1, T7-tagged E.coli T7
    Mouse Sgk1-145M Recombinant Mouse Sgk1 protein, His-tagged E.coli His
    Mouse SGK1-15035M Recombinant Mouse SGK1 Protein Mammalian Cell His
    Chicken SGK1-6046C Recombinant Chicken SGK1 Mammalian Cell His
    Zebrafish SGK1-9896Z Recombinant Zebrafish SGK1 Mammalian Cell His
    Human SGK1-1080H Recombinant Human SGK1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SGK1-22H Recombinant Human SGK1 Protein, His-tagged E. coli His
    Human SGK1-2811H Recombinant Human SGK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Sgk1-5824M Recombinant Mouse Sgk1 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    SGK1 involved in several pathways and played different roles in them. We selected most pathways SGK1 participated on our site, such as FoxO signaling pathway, PIK-Akt signaling pathway, Aldosterone-regulated sodium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SGK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway GABARAPL2; CCNB1; SMAD3A; BRAF; CDKN1BB; CCNB2; MAP2K2; IKBKB; SOS1; KRAS
    PIK-Akt signaling pathway MCL1; Ifna15; INS1; COL6A6; TLR2; EIF4E1B; HSP90B1; PPP2R3A; NRAS; ITGA2
    Aldosterone-regulated sodium reabsorption PIK3R2; ATP1A1; ALPHA-ENAC; MAPK3; SGK1; SFN; PIK3CB; PRKCB; SCNN1B; SCNN1G

    SGK1 has several biochemical functions, for example, ATP binding, calcium channel regulator activity, chloride channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SGK1 itself. We selected most functions SGK1 had, and list some proteins which have the same functions with SGK1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding AARS; KIF2C; PPP2R4; NTPCR; IKBKE; UBA1; ABCG2D; PKM; CLK2; HARS
    calcium channel regulator activity SGK2B; NRXN3; SGK3; PRKCB; CACNA2D2; NPY; SGK2A; PRKG1; NRXN2; STIM1B
    chloride channel regulator activity SGK2B; SGK2A; SGK1; SGK3; SLC9A3R1; BSND; SGK2; CHRNA7
    potassium channel regulator activity SGK1; DLG1; ADRB2; KCNE1L; ABCC9; LRRC26; KCNMB1; KCNIP2; KCNAB3; KCNMB3
    protein binding RC3H2; CXorf40A; EIF5A2; CD2BP2; CSRP2; RNF175; OSBP; DLA; GSTA4; FAAH
    protein serine/threonine kinase activity SLC14A2; PRKCHA; MAP3K13; BCR; CDKL5; SIK2; PRKCQ; NEK12; PLK2B; MKNK1
    protein serine/threonine/tyrosine kinase activity DYRK4; DYRK1AA; PRKAA2; AURKA; AKT1; DYRK1A; PRKCG; TESK1; ACVR2B; AURKC
    sodium channel regulator activity SCN2B; SGK3; SCLT1; PRSS30; CAV3; SGK1; SCN1BA; GPLD1; FXYD1; SCN3B

    SGK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SGK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SGK1.

    CREB1; RABAC1; PDPK1; GADD45G; MAPT; IKBKG; Tcr-alpha; 13514813; PPIAL4D; EIF3F; PFAS; CS; CBR3; LETM1

    Qadri, SM; Su, Y; et al. Endothelial Na+/H+ exchanger NHE1 participates in redox-sensitive leukocyte recruitment triggered by methylglyoxal. CARDIOVASCULAR DIABETOLOGY 13:-(2014).
    Heller, BA; Ghidinelli, M; et al. Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system. JOURNAL OF CELL BIOLOGY 204:1219-1236(2014).

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