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Official Full Name SH3-domain binding protein 2
Background The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms SH3BP2; SH3-domain binding protein 2; Cherubism; SH3 domain-binding protein 2; CRBM; RES4 23; CRPM; FLJ42079; FLJ54978; 3BP-2; 3BP2; 3BP2_HUMAN; Abl SH3 binding protein 2; RES4-23; SH3 domain binding protein 2; TNFAIP3 interacting protein 2; OTTHUMP00000219014; OTTHUMP00000219024; OTTHUMP00000219026; OTTHUMP00000219027; Abl-SH3 binding protein 2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SH3BP2-1871HCL Recombinant Human SH3BP2 293 Cell Lysate HEK293 N/A
    Human SH3BP2-2359H Recombinant Human SH3BP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SH3BP2-708H Recombinant Human SH3BP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SH3BP2-9178H Recombinant Human SH3BP2, His-tagged E.coli His
    Mouse Sh3bp2-5841M Recombinant Mouse Sh3bp2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Chicken SH3BP2-2833C Recombinant Chicken SH3BP2 Mammalian Cell His

    sh3bp2 involved in several pathways and played different roles in them. We selected most pathways sh3bp2 participated on our site, such as Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with sh3bp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Natural killer cell mediated cytotoxicity SHC3; ITGAL; KIR2DS4; BID; KLRD1; IFNB1; IFNA10; KIR2DL3; HLA-E; Casp3

    sh3bp2 has several biochemical functions, for example, SH3 domain binding, SH3/SH2 adaptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by sh3bp2 itself. We selected most functions sh3bp2 had, and list some proteins which have the same functions with sh3bp2. You can find most of the proteins on our site.

    Function Related Protein
    SH3 domain binding PDCD6IP; GJA1; SH2D2A; PTPN12; GRB2; ARHGAP1; CTTNBP2; LANCL1; ERRFI1; FMN1
    SH3/SH2 adaptor activity FCRL2; CD28; PTPN11; HSH2D; LASP1; BLNK; GRB14; SRC; CNTNAP1; GRB7
    protein binding C10orf46; KRTAP9-4; NUAK1; HIST2H3C; ATP6V1C2; ASPA; PLAC9; CRABP1; GATA1A; PTS

    sh3bp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with sh3bp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of sh3bp2.

    VAV1; VAV2; DBNL

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