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Official Full Name split hand/foot malformation (ectrodactyly) type 1
Background The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle.
Synonyms SHFM1; split hand/foot malformation (ectrodactyly) type 1; SHFD1; 26S proteasome complex subunit DSS1; deleted in split hand/foot 1; DSS1; ECD; SEM1; Shfdg1; SHSF1; Deleted in Split-Hand/Split-Foot 1 region; OTTHUMP00000198236; split hand/foot deleted protein 1; deleted in split-hand/split-foot 1; deleted in split hand/split foot protein 1; split hand/foot malformation type 1 protein
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SHFM1-2440H Recombinant human SHFM1, His-tagged E.coli His
    Human SHFM1-2659H Recombinant Human SHFM1, GST-tagged E.coli GST
    Mouse SHFM1-15099M Recombinant Mouse SHFM1 Protein Mammalian Cell His
    Rhesus Macaque SHFM1-4194R Recombinant Rhesus monkey SHFM1 Protein, His-tagged Mammalian Cell His
    Chicken SHFM1-3685C Recombinant Chicken SHFM1 Mammalian Cell His
    Zebrafish SHFM1-9996Z Recombinant Zebrafish SHFM1 Mammalian Cell His

    SHFM1 involved in several pathways and played different roles in them. We selected most pathways SHFM1 participated on our site, such as Proteasome, Homologous recombination, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHFM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Homologous recombination TOP3B; POLD2; XRCC3; TOP3A; POLD1; RPA3; RAD51L3; RAD51L1; RAD51; FUZ
    Epstein-Barr virus infection GTF2B; YWHAZ; NFKB1; IL10RB; YWHAB; MAPK11; CR2; CSNK2A2; YWHAH; SND1

    SHFM1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHFM1 itself. We selected most functions SHFM1 had, and list some proteins which have the same functions with SHFM1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding BRD2; RAC3; DUT; MGRN1; KCNK16; DVL1; HIST1H4I; TRIM16; KCNH1; LIMA1

    SHFM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHFM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SHFM1.


    Xu, ZY; Geng, Q; et al. Multiplex ligation-dependent probe amplification and array comparative genomic hybridization analyses for prenatal diagnosis of cytogenomic abnormalities. MOLECULAR CYTOGENETICS 7:-(2014).
    Shammas, M; Kumar, S; et al. Dysregulation of SHFM1, a Novel Target for Prevention of Genomic Instability in Myeloma, Is Associated with Epigenetic Changes at Specific CpG Sites. BLOOD 124:-(2014).

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