skp1
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  • Official Full Name
  • S-phase kinase-associated protein 1
  • Background
  • This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.
  • Synonyms
  • SKP1; S-phase kinase-associated protein 1; OCP2; p19A; EMC19; SKP1A; OCP-II; TCEB1L; MGC34403; S-phase kinase-associated; protein 1; SIII; OCP-2; p19skp1; OTTHUMP00000159379; OTTHUMP00000159380; OTTHUMP00000228275; OTTHUMP00000228276; OTTHUMP00000228278; OTTHUMP00000228279; OTTHUMP00000228281; organ of Corti protein 2; organ of Corti protein II; cyclin A/CDK2-associated p19; transcription elongation factor B; cyclin A/CDK2-associated protein p19; cyclin-A/CDK2-associated protein p19; RNA polymerase II elongation factor-like protein OCP2
Cat.#:SKP1-367HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SKP1 Protein, His-tagged
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Cat.#:SKP1-011HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SKP1 Protein, His-tagged
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Cat.#:SKP1-1822HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human S-phase Kinase-associated Protein 1
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Cat.#:SKP1-2691HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SKP1, GST-tagged
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Cat.#:SKP1-31408THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SKP1
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Cat.#:SKP1-31409THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SKP1
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Cat.#:SKP1-5416RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SKP1 Protein
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Cat.#:SKP1-918CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus SKP1 Protein, His-tagged
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Cat.#:SKP1-4215RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SKP1 Protein, His-tagged
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Cat.#:SKP1-1305CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SKP1
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Cat.#:SKP1-11006ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SKP1
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Cat.#:SKP1-1813HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SKP1 293 Cell Lysate
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Involved Pathway

SKP1 involved in several pathways and played different roles in them. We selected most pathways SKP1 participated on our site, such as Cell cycle, Oocyte meiosis, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SKP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell cycle
CDC14A; TTK; NDEL1A; ESCO1; CDC20; CCNE2; WEE1; FZR1A; TUBB4A; VRK1
Oocyte meiosis
RPS6KA2; PRKACBA; CCNE1; CDC23; CALML5; AURKA; SMC1B; SPDYA; PPP2R5EB; YWHAE
Ubiquitin mediated proteolysis
SIAH1A; CDC26; NHLRC1; UBE2W; UBE2D2L; UBA6; SMURF1; UBE2IA; UBE2D2A; UBE2Q2
Protein processing in endoplasmic reticulum
SSR3; UBE2E1; BAK1; DNAJB12A; SEC61G; STT3B; NFE2L2A; HNF4B; EDEM2; LMAN2
Wnt signaling pathway
CACYBP; WNT8B; NFATC3; SFRP5; RHOAD; PPP3R2; FZD2; SMAD4; CTBP2A; FZD7
TGF-beta signaling pathway
ACVR2AA; BMPR2; RHOAA; FSTA; BMP6; NDR1; NOG; TNF; NODAL; TFDP1A
Circadian rhythm
PER2; PRKAG3; SKP1; CUL1; RORA; FBXW11; NR1D1; PER3; PER1; RBX1
Herpes simplex infection
TNF; MHC2DAB; EEF1D; USP7; SRPK1B; MAVS; IRF7; CLOCKA; SRSF3; IFNG

Protein Function

SKP1 has several biochemical functions, for example, protein binding, ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SKP1 itself. We selected most functions SKP1 had, and list some proteins which have the same functions with SKP1. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein DHX38; MRPL10; RARS; MED25; CCDC50; FAM119A; APOBEC3G; FAM49B; CXCL14; PSMC3
Function ubiquitin-protein transferase activity
Related Protein LNX1; LTN1; AMFR; BIRC5A; FBXW2; MUL1; UBE2N; FBXO40.1; TRIP12; TRIM37

Interacting Protein

SKP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SKP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SKP1.
SKP2; CUL1

SKP1 Related Articles

Hamorsky, KT; Kouokam, JC; et al. N-Glycosylation of cholera toxin B subunit in Nicotiana benthamiana: impacts on host stress response, production yield and vaccine potential. SCIENTIFIC REPORTS 5:-(2015).
Min, CK; Kwon, YJ; et al. Multiple Orientia tsutsugamushi Ankyrin Repeat Proteins Interact with SCF1 Ubiquitin Ligase Complex and Eukaryotic Elongation Factor 1 alpha. PLOS ONE 9:-(2014).