Recombinant Rhesus monkey SKP1 Protein, His-tagged
Cat.No. : | SKP1-4215R |
Product Overview : | Recombinant Rhesus monkey SKP1 full length or partial length protein was expressed. |
- Specification
- Gene Information
- Related Products
Source : | Mammalian Cells |
Species : | Rhesus monkey |
Tag : | His |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC. |
Storage Buffer : | PBS buffer |
Gene Name : | SKP1 S-phase kinase-associated protein 1 [ Macaca mulatta (Rhesus monkey) ] |
Official Symbol : | SKP1 |
Synonyms : | SKP1; s-phase kinase-associated protein 1; |
Gene ID : | 100423634 |
mRNA Refseq : | NM_001193590 |
Protein Refseq : | NP_001180519 |
MIM : | |
UniProt ID : | I0FL62 |
Products Types
◆ Recombinant Protein | ||
SKP1-367H | Recombinant Human SKP1 Protein, His-tagged | +Inquiry |
SKP1-661C | Recombinant Cynomolgus Monkey SKP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SKP1-5075R | Recombinant Rat SKP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SKP1-4031R | Recombinant Rhesus Macaque SKP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
SKP1-5416R | Recombinant Rat SKP1 Protein | +Inquiry |
◆ Lysates | ||
SKP1-1813HCL | Recombinant Human SKP1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionSKP1 has been implicated in the regulation of cellular senescence, a state of irreversible growth arrest associated with aging. It interacts with cellular factors involved in senescence, such as p16INK4a and p27Kip1, facilitating their degradation and promoting cell cycle progression. The dysregulation of SKP1-mediated protein degradation may contribute to cellular senescence and age-related diseases.
SKP1 forms a scaffold that interacts with Cullin proteins, which provide the backbone structure of the SCF complex. Additionally, SKP1 directly interacts with F-box proteins, enabling their recruitment and assembly into the complex. The precise interactions between SKP1, Cullin, and F-box proteins are crucial for the stability and functionality of the SCF complex and its ability to target specific proteins for degradation.
SKP1 is a key component of the SCF complex, which acts as an E3 ubiquitin ligase involved in protein degradation. Through its interaction with F-box proteins, SKP1 helps recruit target proteins for ubiquitination and subsequent proteasomal degradation. In the context of the cell cycle, SKP1 plays a crucial role in the timely degradation of cell cycle regulators, ensuring proper cell cycle progression and coordination.
SKP1 has been shown to be involved in immune responses by regulating the degradation of immune signaling proteins. It influences the stability of proteins involved in immune cell activation, differentiation, and function. The precise role of SKP1 in immune system regulation and specific immune processes requires further investigation.
Alterations in SKP1 expression or function have been associated with various cancers. Dysregulation of SKP1-mediated protein degradation can lead to aberrant accumulation of oncogenic proteins or the insufficient degradation of tumor suppressor proteins, contributing to tumorigenesis. Understanding the molecular mechanisms underlying SKP1 dysregulation in cancer development may provide insights for therapeutic interventions.
SKP1 is a highly conserved protein that is ubiquitously expressed in all eukaryotic cells. It is primarily localized in the cytoplasm and nucleoplasm, where it functions as a component of the SCF (SKP1-CUL1-F-box protein) complex. The distribution of SKP1 among different tissues and cell types is largely consistent, indicating its essential role in various cellular processes.
SKP1 acts as a molecular scaffold that facilitates protein-protein interactions and assembly of multi-protein complexes. In addition to its role in the SCF complex, SKP1 interacts with various proteins involved in cellular signaling pathways, including kinases, transcription factors, and cell cycle regulators. These interactions regulate diverse cellular processes, such as cell proliferation, differentiation, and apoptosis.
Customer Reviews (3)
Write a reviewI am incredibly satisfied with the level of assistance and support provided by the manufacturer's team.
The packaging of the reagent is intact, with no damage or leakage.
Satisfactory results are consistently achieved, whether in laboratory or field environments, with this experimental reagent.
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