Description : |
The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
70.1 kDa |
AA Sequence : |
MLSAIYTVLAGLLFLPLLVNLCCPY FFQDIGYFLKVAAVGRRVRSYGKRR PARTILRAFLEKARQTPHKPFLLFR DETLTYAQVDRRSNQVARALHDHLG LRQGDCVALLMGNEPAYVWLWLGLV KLGCAMACLNYNIRAKSLLHCFQCC GAKVLLVSPELQAAVEEILPSLKKD DVSIYYVSRTSNTDGIDSFLDKVDE VSTEPIPESWRSEVTFSTPALYIYT SGTTGLPKAAMITHQRIWYGTGLTF VSGLKADDVIYITLPFYHSAALLIG IHGCIVAGATLALRTKFSASQFWDD CRKYNVTVIQYIGELLRYLCNSPQK PNDRDHKVRLALGNGLRGDVWRQFV KRFGDICIYEFYAATEGNIGFMNYA RKVGAVGRVNYLQKKIITYDLIKYD VEKDEPVRDENGYCVRVPKGEVGLL VCKITQLTPFNGYAGAKAQTEKKKL RDVFKKGDLYFNSGDLLMVDHENFI YFHDRVGDTFRWKGENVATTEVADT VGLVDFVQEVNVYGVHVPDHEGRIG MASIKMKENHEFDGKKLFQHIADYL PSYARPRFLRIQDTIEITGTFKHRK MTLVEEGFNPAVIKDALYFLDDTAK MYVPMTEDIYNAISAKTLKLTRTRP LEQKLISEEDLAANDILDYKDDDDK V |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |