SMAD3 Protein


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Official Full Name SMAD family member 3
Background The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]
Synonyms SMAD3; SMAD family member 3; LDS3; LDS1C; MADH3; JV15-2; HSPC193; HsT17436; mothers against decapentaplegic homolog 3; mad3; hMAD-3; hSMAD3; MAD homolog 3; mad homolog JV15-2; mad protein homolog; mothers against DPP homolog 3; SMA- and MAD-related protein 3; SMAD, mothers against DPP homolog 3; MAD, mothers against decapentaplegic homolog 3;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • MBP
    • His-SUMO
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SMAD3-2256H Recombinant Human SMAD3 protein, His-tagged Insect Cell His
    Human SMAD3-3506H Recombinant Human SMAD3 protein, His-SUMO-tagged E.coli His-SUMO
    Human SMAD3-1094H Recombinant Human SMAD Family Member 3, GST-tagged E.coli GST
    Human SMAD3-1918H Recombinant Human SMAD3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SMAD3-295H Recombinant Human SMAD3 protein, GST-tagged E.coli GST
    Human SMAD3-304H Recombinant Human SMAD3 Protein, His-tagged E.coli His
    Human SMAD3-31190TH Recombinant Human SMAD3, His-tagged E.coli His
    Human SMAD3-31191TH Recombinant Human SMAD3 E.coli N/A
    Human SMAD3-326H Recombinant Human SMAD3 protein, His/MBP-tagged E.coli His/MBP
    Human SMAD3-327H Recombinant Human SMAD3 protein, His/MBP-tagged E.coli His/MBP
    Human SMAD3-4599H Recombinant SMAD Family Member 3, His-tagged Human His
    Human SMAD3-4788H Recombinant Human SMAD3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SMAD3-6915H Recombinant Human SMAD Family Member 3, His-tagged E.coli His
    Mouse SMAD3-001MCL Recombinant Mouse SMAD3 cell lysate Insect Cell N/A
    Mouse Smad3-305M Recombinant Mouse Smad3 Protein, His-tagged E.coli His
    Mouse SMAD3-532M Recombinant Mouse Smad3, His-GST tagged Insect Cell GST
    Mouse Smad3-5951M Recombinant Mouse Smad3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat SMAD3-5608R Recombinant Rat SMAD3 Protein Mammalian Cell His
    Rhesus Macaque SMAD3-4331R Recombinant Rhesus monkey SMAD3 Protein, His-tagged Mammalian Cell His
    Chicken SMAD3-6045C Recombinant Chicken SMAD3 Mammalian Cell His

    SMAD3 involved in several pathways and played different roles in them. We selected most pathways SMAD3 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway G6PCA.1; CCNB3; PTENB; CAT; INSB; IRS2; BRAF; IGF1; PRKAA2; PCK2
    Wnt signaling pathway PPP3CCB; AXIN1; CTBP2A; RAC3A; MAPK8A; RHOAA; SOX17; MAPK8; WNT6; FZD9
    TGF-beta signaling pathway BMP6; SMAD7; INHBC; TGFB3; ACVR2B; NOG; ROCK2B; BMP8B; LTBP1; TGFB2
    Hippo signaling pathway FZD5; PRKCI; SMAD2; ID1; PPP2R2D; ITGB2L; LEF1; YAP1; BMP8B; PPP1CA
    Adherens junction ACTN3A; SSX2IP; CTNNB1; TGFBR2; WASF3; CDC42L; BAIAP2; ACTN2B; RHOAC; ACTN1
    Signaling pathways regulating pluripotency of stem cells FZD9; WNT3; WNT3A; WNT2B; SMAD9; MEIS1; MAPK11; INHBE; FZD5; ACVR1B
    Chagas disease (American trypanosomiasis) C1QC; PPP2CA; MAPK12; GNAI3; MAPK1; PPP2R1B; CCL3; CD3E; MAPK3; CD3G
    Hepatitis B IKBKG; BAX; IFNA7; Casp3; STAT5A; AKT2; HRAS; CREB3L3; PIK3CG; MYD88
    Pathways in cancer BIRC7; NRAS; RXRA; PIK3R2; RELA; FZD5; BIRC2; FGF1; FN1; FZD10
    Colorectal cancer CYCS; TGFB3; PIK3R2; MAPK3; CASP9; APPL1; MAPK9; TGFBR1; TGFB1; RAC3
    Pancreatic cancer SMAD3; MAPK10; PIK3R3; RAC3; PIK3CA; SMAD4; TGFBR2; PIK3CD; RALBP1; MAP2K1
    Chronic myeloid leukemia KRAS; CTBP1; PIK3CB; MAPK3; HRAS; RUNX1; SMAD3; ABL1; IKBKB; MAP2K2
    Inflammatory bowel disease (IBD) HLA-DRB5; HLA-DOB; TLR2; IL12RB1; STAT1; IL13; TLR5; IFNGR1; IL21R; IL6

    SMAD3 has several biochemical functions, for example, R-SMAD binding, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD3 itself. We selected most functions SMAD3 had, and list some proteins which have the same functions with SMAD3. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II activating transcription factor binding NEUROD1; JUN; TBX6; DUSP26; CREB1; CREBBP; ISL1; TBX3; RB1; SIN3A
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ASCL1; MEOX1; HELT; MITF; EP300; NR2C1; NKX2-5; TFE3B; LEF1; OTX2
    bHLH transcription factor binding USF2; TWIST1; SP1; IKZF4; TCF21; TCF3B; ISL1; TCF3A; TCF4; PSMD9
    beta-catenin binding SOX9; VCL; FAM123B; DACT1; PTPRU; SMAD7; SMAD3; TRPC4; TCF7L2; APC2
    chromatin DNA binding VAX1; HIST1H1E; SLAMF7; RUVBL2; MYOD1; MYOG; PRDM14; WBP2; INSM1A; RXRA
    co-SMAD binding TRIM33; SMAD2; SMAD3; GATA4; SMAD6; SMAD1; USP9X; FOXH1; CITED1; TGIF1
    collagen binding ITGA9; CTSS; VWF; DDR1; DDR2; CHADL; PODN; MRC2; PCOLCE2; MMP9
    core promoter proximal region sequence-specific DNA binding ZFP516; DMRTC1C2; GATA3; SP3A; SP3; UHRF1; CREBBP; PAX2; TFAP2A; SMAD4
    enhancer binding ARNT; RAI1; SOX9; SMAD3; ELL3; TCF3; SMAD2; TCF12; TIPARP; SP1
    identical protein binding DVL1; KCNJ2; SLC22A1; UBE4A; APLP2; SMAD1; RUVBL2; ACY3; APPL1; ALS2CL
    phosphatase binding TRPC4AP; CARHSP1; SH3GL1; DLG1L; DLG1; PPP1R32; PPP1R26; SLC9A3R1; CRY1; PPP1R36
    protein binding SMAD3; SERPINA1; DPPA4; SLC4A1AP; HCFC1; PLEKHF2; GRIFIN; EPB49; CLASP1; PARP9
    protein heterodimerization activity SMC2; UGT1A6A; GRIN2A; SOX15; HIST1H3A; TGFB3; RRAGC; NKX2-5; OSTA; SYT16
    protein homodimerization activity ATP2A1; SNF8; APOA4; SRGAP2A; GRHPR; CALCOCO2; BCL2L2; TRIM5; ADSSL1; PDGFA
    protein kinase binding H2AFY; ADIPOR1; PPP1CC; PRKACA; NGFRAP1; VDAC1; STAT3; NEFH; CCND1; PRDX3
    sequence-specific DNA binding POU4F2; NKX3.2; HOXD4; NR5A2; TCF7L2; DBPA; LHX8A; GATA1; NR2C2; FOXJ3
    transcription factor activity, RNA polymerase II core promoter sequence-specific MAX; NKX3; PAX7; MEF2C; HEYL; TFAP2B; HEY2; HEY1; SMAD3
    contributes_to transcription factor activity, protein binding SMAD3; SMAD4
    transcription factor activity, sequence-specific DNA binding RORC; POU4F2; EOMESB; DMRTC1C2; SMAD6A; MLXIPL; RHOXF1; HMGA1B; CEBPD; FOXP1A
    contributes_to transcription factor activity, sequence-specific DNA binding SMAD4; TAF7; NKX2; TRIM28; SOX1A; HNRNPAB; SMAD3; TAF10; SOX19B; NKX2-5
    transcription factor binding RBFOX2; NFIA; BCL3; FOXO1; SIRT1; HDAC1; APBB3; DACT2; KCTD1; NFATC3
    transcription regulatory region DNA binding CTCFL; PHB; PAX2; SP1; MEN1; WT1; NFKB1; SFPQ; SMAD7; THRA
    transforming growth factor beta receptor binding BMP8B; GDF6; NDR2; NDR1; INHBB; INHBC; BMP6; GDF9; GDF1; LFT2
    transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity SMAD2; SMAD3; SMAD1; SMAD9
    ubiquitin binding CXCR4; OTUB1B; UBE2NB; FAN1; NBR1; NEDD4; IWS1; DNAJC2; HSPB1; RNF168
    ubiquitin protein ligase binding CDKN1A; UBE2J1; TRIB1; PTPN22; UBE2A; CKB; FAF1; IKBKG; NGFR; CUL4A
    zinc ion binding ALPP; NR5A1A; RASGRP1; GATAD2A; DPF2L; AMFR; FBXL19; TIMM10; GATAD2AB; ZMAT3

    SMAD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD3.

    SMAD4; SKI

    Smithrithee, R; Niyonsaba, F; et al. Human beta-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes. JOURNAL OF DERMATOLOGICAL SCIENCE 77:46-53(2015).
    McMillin, M; Galindo, C; et al. Gli1 activation and protection against hepatic encephalopathy is suppressed by circulating transforming growth factor beta 1 in mice. JOURNAL OF HEPATOLOGY 61:1260-1266(2014).


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