SMAD3
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Official Full Name
SMAD family member 3
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Background
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009] -
Synonyms
SMAD3; SMAD family member 3; LDS3; LDS1C; MADH3; JV15-2; HSPC193; HsT17436; mothers against decapentaplegic homolog 3; mad3; hMAD-3; hSMAD3; MAD homolog 3; mad homolog JV15-2; mad protein homolog; mothers against DPP homolog 3; SMA- and MAD-related protein 3; SMAD, mothers against DPP homolog 3; MAD, mothers against decapentaplegic homolog 3;
- Involved Pathway
- Protein Function
- Interacting Protein
- SMAD3 Related Articles
- SMAD3 Related Gene Family
- SMAD3 Related Research Area
- SMAD3 Related Signal Pathway
SMAD3 involved in several pathways and played different roles in them. We selected most pathways SMAD3 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | NLK;KLF2B;RAF1A;MAPK3;PLK3;FOXO6;PIK3R3A;FOXO3B;G6PCA.1 |
| Cell cycle | CEP290;MCM4;MSH5;KIF20A;ANAPC11;PHF8;HAUS2;MCM7;WEE1 |
| Endocytosis | SMAD3A;FGFR3;GBF1;RLN1;IST1;ARFGAP2;PARD6GA;SPG20;VTA1 |
| Wnt signaling pathway | PPP3R2;FZD8;PSEN1;RHOAD;MMP7;PORCNL;BAMBIA;PRKCA;DVL3A |
| TGF-beta signaling pathway | TGFBR1B;GDF7;BMP6;BMPR1BA;INHBE;SKP1;SP1;SMAD4;ACVR1C |
| Hippo signaling pathway | LEF1;FZD2;FZD7;MOB1A;BTRC;LLGL2;TP73;CDH1;TEAD2 |
| Adherens junction | MET;ACTB1;FGFR1A;RAC3A;PTPRJ;SSX2IPA;SNAI2;Fert2;PTPRF |
| Signaling pathways regulating pluripotency of stem cells | PIK3CB;PCGF2;PIK3CD;FZD1;FZD5;KRAS;PIK3CG;HNF1A;SMAD3 |
| Chagas disease (American trypanosomiasis) | TGFBR2;SMAD2;NFKB1;MAPK1;IKBKG;C1QB;IL1B;TICAM1;PIK3CD |
| Hepatitis B | DDB2;HSPG2;CREB3L1;MAVS;IKBKB;CREB3L3;BIRC5;PCNA;IFNB1 |
| HTLV-I infection | ELK4;ANAPC7;FZD10;IKBKB;PIK3R2;POLE3;Fzd4;MSX1;ANAPC11 |
| Pathways in cancer | GNG8;CXCR4;GNG7;FZD6;FZD5;PTCH2;TCF7L2;ARHGEF1;TFG |
| Colorectal cancer | CASP9;MAPK10;MAPK1;RAC1;BAD;TGFB2;BRAF;TGFB1;MSH2 |
| Pancreatic cancer | RB1;PIK3R1;MAP2K1;CDC42;MAPK1;TGFB3;PIK3R3;CASP9;AKT1 |
| Chronic myeloid leukemia | GRB2;SHC4;RB1;PIK3CD;PIK3R3;TGFBR2;CTBP1;SHC1;NFKBIA |
| Inflammatory bowel disease (IBD) | HLA-DRB5;STAT4;TLR5;IFNGR1;IL13;FOXP3;TGFB3;NFKB1;IFNGR2 |
SMAD3 has several biochemical functions, for example, R-SMAD binding, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD3 itself. We selected most functions SMAD3 had, and list some proteins which have the same functions with SMAD3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| R-SMAD binding | SMAD4;ZC3H3;PARP1;PMEPA1;TRIM33;C18orf1;MEN1;PAX6;ZEB2 |
| RNA polymerase II activating transcription factor binding | SMAD3;LMO2;HIPK2;SIN3A;TBX6;RB1;HEY2;POU1F1;SETD3 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | ELF4;ZIC3;MIXL1;MLXIPL;HOXA2;NR2C1;Ar;HLTF;MYOG |
| bHLH transcription factor binding | TCF3B;USF1;ISL1;TCF3;TCF3A;SOX9;USF2;TCF12;RUNX2 |
| beta-catenin binding | PTBP3;CTNNA3;SOX17;DVL3;SHROOM2;VCL;CDH24;LZIC;SMAD7 |
| chromatin DNA binding | PER1;VAX2;APEX1;WBP2;THRA;SMAD3;PRDM14;GRHL2;GRHL1 |
| co-SMAD binding | TRIM33;GATA4;SMAD3;USP9X;FOXH1;SMAD2;TGIF1;SMAD1;CITED1 |
| collagen binding | CCBE1;PDGFB;CTSS;TLL1;CTSL1;TGFBI;CTSB;LRRC15;SMAD7 |
| core promoter proximal region sequence-specific DNA binding | SP3;MEF2C;UHRF1;DMRT3A;DMRTC2;SMAD4;ZFP516;DMRT3;GATA3 |
| enhancer binding | SOX9;TIPARP;TCF12;SMAD3;MESP1;LEF1;SP1;RAI1;SMAD2 |
| identical protein binding | DAPK1;AMOTL2;SERPINA1A;TYROBP;PLN;FNBP1;VPS4B;SH3GL2;APOH |
| phosphatase binding | PPP1R26;PPP1R36;SH2D4A;KIAA0649;ELFN2;CRY2;CRY1;SPRED1;MAPK1 |
| protein binding | EDNRB;ASAP3;ERP27;USP36;O3far1;FCN3;C12orf68;ZNF614;GNA14 |
| protein heterodimerization activity | SMC1A;RRAGD;SNX6;BCL2L1;HIST1H2B5;HIST1H4E;ADIPOR2;H2-AA;CREB3L3 |
| protein homodimerization activity | ADAM10;UGT1A6;CRYBA1;GLA;WWTR1;GRIK2;GRM6;SLC11A1;FAM109B |
| protein kinase binding | NIPAL1;AKAP1;ADCY6;CCND3;PPP1CB;TNIP2;CCNA2;MAP2K3;TPRKB |
| sequence-specific DNA binding | UNCX;MAF;RERE;JUNBB;NR2E1;LHX5;FOXS1;FOXI2;NKX2-4 |
| transcription factor activity, RNA polymerase II core promoter sequence-specific | NKX3;MAX;TFAP2B;HEY2;MEF2C;HEYL;SMAD3;PAX7;HEY1 |
| contributes_to transcription factor activity, protein binding | SMAD3;SMAD4 |
| transcription factor activity, sequence-specific DNA binding | FLI1;STAT2;TTC4;ZRANB2;ZNF726;GATA6;FOXN2B;ZBTB17;TFAM |
| contributes_to transcription factor activity, sequence-specific DNA binding | VDRA;VDRB;NKX2;SMAD4;HNRNPAB;NFE2L2A;TAF12;SOX1A;TAF10 |
| transcription factor binding | TAF1;NAB1;APBB1;PSMD10;HMGA1;HES3;CREBBP;LCOR;SIRT1 |
| transcription regulatory region DNA binding | ZFHX3;CALCOCO1;GFI1;RFX3;TAL1;PAX8;GLIS2;FOXC1;ATMIN |
| transforming growth factor beta receptor binding | SMURF2;GDF15;FKBP1A;INHBA;BMP15;GDF9;BMP7A;INHBB;LEFTY2 |
| transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity | SMAD3;SMAD1;SMAD9;SMAD2 |
| ubiquitin binding | OTUB1A;USP5;KCNS1;IDE;FAF1;MARK4;SQSTM1;UBXN2B;TRIM32 |
| ubiquitin protein ligase binding | UBE2R2;ANAPC2;HSPA1L;CXCR4;PRKAR2B;CUL9;ASB4;RPA2;TMEM173 |
| zinc ion binding | BTR12;LNPEP;ZNF385B;RARG;ZFYVE1;GATA2;ADAM7;MMP23BB;RTN4IP1 |
SMAD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD3.
SMAD4; SKI
- Q&As
- Reviews
Q&As (6)
Ask a questionThe expression level of SMAD3 protein can be detected by immunohistochemistry, western blotting, real-time PCR and other techniques. At the same time, the activity of SMAD3 protein can be assessed by detecting the phosphorylation level and the amount of SMAD3 protein within the nucleus.
interaction between SMAD3 protein and other proteins is regulated by a variety of factors, including phosphorylation, methylation, acetylation and other modifications, and interactions with other proteins. These factors can affect the interaction between SMAD3 protein and other proteins, and then affect the regulation process of TGF-β signal transduction pathway.
In the TGF-β signaling pathway, SMAD3 protein is activated by TGF-β to form complexes with other SMAD proteins, and then enters the nucleus to regulate the expression of specific genes, thereby affecting the growth, differentiation, apoptosis and immune response of cells.
expression level of SMAD3 protein is regulated by a variety of factors, including gene transcription, translation, modification, and degradation. These factors can affect the expression level of SMAD3 protein, which in turn affects the growth, differentiation and apoptosis of cells.
The main function of SMAD3 protein is to transmit signals in the TGF-β signal transduction pathway and regulate cell growth, differentiation, apoptosis and immune response.
SMAD3 protein is a protein that plays a key role in intracellular signal transduction and belongs to the SMAD family. It is an effector molecule in the transforming growth factor-β (TGF-β) signaling pathway.
Customer Reviews (3)
Write a reviewHigh expression level, good stability, suitable for high precision experiments. -
Compared with other brands I have used, this brand is more stable and reliable. -
Strong antibacterial activity, not easy to be contaminated. -
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