SMAD3 Protein


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Official Full Name SMAD family member 3
Background The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]
Synonyms SMAD3; SMAD family member 3; LDS3; LDS1C; MADH3; JV15-2; HSPC193; HsT17436; mothers against decapentaplegic homolog 3; mad3; hMAD-3; hSMAD3; MAD homolog 3; mad homolog JV15-2; mad protein homolog; mothers against DPP homolog 3; SMA- and MAD-related protein 3; SMAD, mothers against DPP homolog 3; MAD, mothers against decapentaplegic homolog 3;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • MBP
    • His-SUMO
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SMAD3-1094H Recombinant Human SMAD Family Member 3, GST-tagged E.coli GST
    Human SMAD3-295H Recombinant Human SMAD3 protein, GST-tagged E.coli GST
    Human SMAD3-31190TH Recombinant Human SMAD3, His-tagged E.coli His
    Human SMAD3-31191TH Recombinant Human SMAD3 E.coli N/A
    Human SMAD3-326H Recombinant Human SMAD3 protein, His/MBP-tagged E.coli His/MBP
    Human SMAD3-327H Recombinant Human SMAD3 protein, His/MBP-tagged E.coli His/MBP
    Human SMAD3-4599H Recombinant SMAD Family Member 3, His-tagged Human His
    Human SMAD3-6915H Recombinant Human SMAD Family Member 3, His-tagged E.coli His
    Mouse SMAD3-532M Recombinant Mouse Smad3, His-GST tagged Insect Cell GST
    Rat SMAD3-5608R Recombinant Rat SMAD3 Protein Mammalian Cell His
    Rhesus Macaque SMAD3-4331R Recombinant Rhesus monkey SMAD3 Protein, His-tagged Mammalian Cell His
    Chicken SMAD3-6045C Recombinant Chicken SMAD3 Mammalian Cell His
    Mouse SMAD3-001MCL Recombinant Mouse SMAD3 cell lysate Insect Cell N/A
    Human SMAD3-1973HF Recombinant Full Length Human SMAD3 Protein, GST-tagged E.coli GST
    Human SMAD3-2256H Recombinant Human SMAD3 protein, His-tagged Insect Cell His
    Human SMAD3-3506H Recombinant Human SMAD3 protein, His-SUMO-tagged E.coli His-SUMO
    Human SMAD3-1918H Recombinant Human SMAD3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SMAD3-304H Recombinant Human SMAD3 Protein, His-tagged E.coli His
    Human SMAD3-4788H Recombinant Human SMAD3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Smad3-305M Recombinant Mouse Smad3 Protein, His-tagged E.coli His
    Mouse Smad3-5951M Recombinant Mouse Smad3 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    SMAD3 involved in several pathways and played different roles in them. We selected most pathways SMAD3 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway PRKAB2; RBL2; G6PC; PRKAB1; SETD7; FBXO32; KLF2A; MDM2; CDKN2B; SGK2B
    Wnt signaling pathway BTRC; RAC2; TCF7L1A; EP300; GSK3AA; RUVBL1; APC; CCND3; DAAM1; PPP3R2
    TGF-beta signaling pathway ROCK1; BMPR2B; INHBAB; RBL1; INHBE; THBS1; IFNG1-2; RHOAD; BMP7; AMH
    Hippo signaling pathway FGF1; ACTG1; TEAD1; Fzd4; TGFB3; BBC3; WTIP; MOB1A; CDH1; WNT7B
    Adherens junction PVRL3B; NLK2; TCF7L1A; AASS; BAIAP2; TGFBR1; INSR; FER; SMAD4; INSRB
    Signaling pathways regulating pluripotency of stem cells SMAD4; PIK3CB; WNT7B; ACVR2B; ID4; WNT3; PAX6; MAPK11; GRB2; FZD9
    Chagas disease (American trypanosomiasis) FOS; Fasl; IRAK1; PIK3CB; GNAI2; IL1B2; CCL5; PIK3CA; PLCB2; IL6
    Hepatitis B CCNA2; FASLG; TGFB3; CASP8; CCND1; IFN-a; PRKCA; MYD88; VDAC3; CASP10
    Pathways in cancer PIK3CB; MMP9; PLD1; RET; PIK3CA; CBLC; PIK3R3; PTGER2; FGF17; PTGER4
    Colorectal cancer CYCS; FOS; PIK3CG; APC2; MAPK8; RAC2; MAPK9; RHOA; Casp3; AXIN2
    Pancreatic cancer RB1; RAD51; TGFB3; SMAD3; TGFA; PIK3CG; TGFB2; KRAS; MAPK1; RELA
    Chronic myeloid leukemia ABL1; IKBKB; CCND1; PIK3R3; TGFBR1; HDAC1; MECOM; BCR; MAP2K2; MAPK3
    Inflammatory bowel disease (IBD) TBX21; HLA-DRB3; IL2RG; HLA-DQA2; IL12B; IL21R; Il23a; Il12b; HLA-DRB5; IL18RAP; H2-AB1

    SMAD3 has several biochemical functions, for example, R-SMAD binding, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD3 itself. We selected most functions SMAD3 had, and list some proteins which have the same functions with SMAD3. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II activating transcription factor binding ATF2; SIN3A; IFI27; BHLHE40; BEX1; HIPK2; NFE2L2; ISL1; JUN; EOMES
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GMEB1; NKX2; HOXA5; SIX1; PGR; NACC2; EP300; NKX3-2; ARNT2; DPF2
    bHLH transcription factor binding TCF4; TCF12; LMO2; FOXH1; USF1; SMAD3; HAND1; TCF3B; RUNX2; TWIST1
    beta-catenin binding KLF4; PTPRJ; TAX1BP3; BCL9L; SALL1; APC2; GRIP1; AXIN2; TBL1X; GLI3
    chromatin DNA binding SRF; ATOH1; NOTCH1; INSM1B; MED1; GRHL3; RXRA; BCL6; EZH2; RELA
    co-SMAD binding TRIM33; SMAD3; CITED1; SMAD6; GATA4; TGIF1; SMAD2; FOXH1; USP9X; SMAD1
    collagen binding NID2; CTSS; ITGA3; GPR56; DCN; CTSL1; TLL1; GP5; MRC2; MMP9
    core promoter proximal region sequence-specific DNA binding DMRTA1; DMRTA2; GATA3; KLF4; DMRT3A; DMRT2B; ZFP516; DMRT2A; SP3A; SMAD4
    enhancer binding MESP1; ARNT; SMAD3; FOXH1; SMAD2; ELL3; RAI1; SP1; AHR; TCF3
    identical protein binding CCT7; COL1A2; SCHIP1; NIF3L1; GPR50; AMELX; DACT3; GBP5; ATL1; GUCY2E
    phosphatase binding PPARA; DLG1; DYSFIP1; SH3RF2; PPP1R27; CSRNP2; TSC2; PPP1R37; TRPC4AP; TPRN
    protein binding SVIL; MTMR2; H3F3C; SYNM; EDDM3B; DAPK2; KHDRBS2; EXOSC2; GFAP; THRB
    protein heterodimerization activity PDX1; PAFAH1B3; NFYB; TLX1; ARNT; HIST4H4; GTF2A2; ZHX1; ABCG1; PDSS2
    protein homodimerization activity CAMK2A; TESCA; TRPM8; TMEM173; LRRK2; TBX1; PFKM; BHLHE40; NKX2-5; GSS
    protein kinase binding FER; IKBKB; CDK5RAP3; PTPN23; PTPRJ; SQSTM1; PIFO; SPRY2; BCAR1; CDC25C
    sequence-specific DNA binding PAX6B; ZFP536; ZFP42; HLX; RORCA; PPARD; TLX3; NKX2.2B; ATF7B; FOXE1
    transcription factor activity, RNA polymerase II core promoter sequence-specific HEY2; MEF2C; TFAP2B; MAX; NKX3; HEYL; HEY1; SMAD3; PAX7
    contributes_to transcription factor activity, protein binding SMAD4; SMAD3
    transcription factor activity, sequence-specific DNA binding GATAD2AB; CSRNP2; ALX1; STAT4; OTX1B; ZFP770; HOMEZB; XBP1; ZNF213; ZNF550
    contributes_to transcription factor activity, sequence-specific DNA binding VDRB; TAF6; NKX2-5; SOX1B; VDRA; MAFGB; GATA4; NFE2L2A; RXRA; NKX2
    transcription factor binding THRA; MDFI; HES3; HDAC1; AGTR2; HEY1; KAT2A; PIAS1; NCOA2; FLNA
    transcription regulatory region DNA binding CEBPA; CREB3L2; PROX1; CDK5RAP2; NR1H3; TP63; TCF7; GRHL1; ERBB4; KLF11
    transforming growth factor beta receptor binding MSTNA; NDR1; SMAD2; GDF5; BMP5; USP15; LFT1; LFT2; MSTNB; NDR2
    transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity SMAD9; SMAD2; SMAD1; SMAD3
    ubiquitin binding AUP1; USP13; UBXN1; OTUB1B; UBE2NB; FAF2; FAM125A; KCNS1; UCHL3; NPLOC4
    ubiquitin protein ligase binding UBE2R2; UBE2G1; POLR2A; DAXX; UBE2T; STUB1; AXIN2; TMEM173; RRAGA; UBXN6
    zinc ion binding NPSN; RABGEF1L; S100A12; PHF17; RNF126; ZSWIM2; ZDHHC5A; ZNF622; PCGF3; NANOS3

    SMAD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD3.

    SMAD4; SKI

    Smithrithee, R; Niyonsaba, F; et al. Human beta-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes. JOURNAL OF DERMATOLOGICAL SCIENCE 77:46-53(2015).
    McMillin, M; Galindo, C; et al. Gli1 activation and protection against hepatic encephalopathy is suppressed by circulating transforming growth factor beta 1 in mice. JOURNAL OF HEPATOLOGY 61:1260-1266(2014).


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