SMAD3 Protein


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Official Full Name SMAD family member 3
Background The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]
Synonyms SMAD3; SMAD family member 3; LDS3; LDS1C; MADH3; JV15-2; HSPC193; HsT17436; mothers against decapentaplegic homolog 3; mad3; hMAD-3; hSMAD3; MAD homolog 3; mad homolog JV15-2; mad protein homolog; mothers against DPP homolog 3; SMA- and MAD-related protein 3; SMAD, mothers against DPP homolog 3; MAD, mothers against decapentaplegic homolog 3;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Tag :
    • Flag
    • GST
    • His
    • MBP
    • His-SUMO
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SMAD3-1094H Recombinant Human SMAD Family Member 3, GST-tagged E.coli GST Inquiry
    Human SMAD3-295H Recombinant Human SMAD3 protein, GST-tagged E.coli GST Inquiry
    Human SMAD3-31190TH Recombinant Human SMAD3, His-tagged E.coli His Inquiry
    Human SMAD3-31191TH Recombinant Human SMAD3 E.coli N/A Inquiry
    Human SMAD3-326H Recombinant Human SMAD3 protein, His/MBP-tagged E.coli His/MBP Inquiry
    Human SMAD3-327H Recombinant Human SMAD3 protein, His/MBP-tagged E.coli His/MBP Inquiry
    Human SMAD3-4599H Recombinant SMAD Family Member 3, His-tagged Human His Inquiry
    Human SMAD3-6915H Recombinant Human SMAD Family Member 3, His-tagged E.coli His Inquiry
    Mouse SMAD3-532M Recombinant Mouse Smad3, His-GST tagged Insect Cell GST Inquiry
    Rat SMAD3-5608R Recombinant Rat SMAD3 Protein Mammalian Cell His Inquiry
    Rhesus Macaque SMAD3-4331R Recombinant Rhesus monkey SMAD3 Protein, His-tagged Mammalian Cell His Inquiry
    Chicken SMAD3-6045C Recombinant Chicken SMAD3 Mammalian Cell His Inquiry
    Mouse SMAD3-001MCL Recombinant Mouse SMAD3 cell lysate Insect Cell N/A Inquiry
    Human SMAD3-1973HF Recombinant Full Length Human SMAD3 Protein, GST-tagged E.coli GST Inquiry
    Human SMAD3-2256H Recombinant Human SMAD3 protein, His-tagged Insect Cell His Inquiry
    Human SMAD3-227HFL Recombinant Full Length Human SMAD3 Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Human SMAD3-3506H Recombinant Human SMAD3 protein, His-SUMO-tagged E.coli His-SUMO Inquiry
    Human SMAD3-1918H Recombinant Human SMAD3 Protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Human SMAD3-304H Recombinant Human SMAD3 Protein, His-tagged E.coli His Inquiry
    Human SMAD3-4788H Recombinant Human SMAD3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Mouse Smad3-305M Recombinant Mouse Smad3 Protein, His-tagged E.coli His Inquiry
    Mouse Smad3-5951M Recombinant Mouse Smad3 Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry

    SMAD3 involved in several pathways and played different roles in them. We selected most pathways SMAD3 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway SMAD2; HRASB; STAT3; NLK1; SLC2A4; NLK2; AKT2L; MAPK12; TGFBR2; AKT3A
    Endocytosis RAB5B; RAB31; AMPH; ADRB3A; SMAP1; ARAP3; WAS; EGFRA; KIT; D6WSU116E
    Wnt signaling pathway FBXW11B; PRKACBB; PPP3R2; FZD8; RUVBL1; NLK1; PRKCG; NFATC3; VANGL1; TP53
    TGF-beta signaling pathway CUL1B; PPP2CB; TGFBR1; SMAD7; SMAD6; PPP2CA; BMPR1BA; INHBE; ZFYVE16; PPP2R1B
    Hippo signaling pathway FZD7; TGFB2; BBC3; GDF6; TGFB1; YWHAE; FZD6; FZD3; AJUBA; WNT5B
    Adherens junction CDH1; EP300; SSX2IPA; WASB; PARD3; TCF7L2; CTNNA1; SRC; CTNNB1; PTPRM
    Signaling pathways regulating pluripotency of stem cells TCF3; WNT16; WNT3; BMI1; ID3; WNT8B; PIK3R5; Fzd4; WNT7B; IGF1
    Chagas disease (American trypanosomiasis) CD3G; MYD88; C1QA; FOS; C3; GNA14; PIK3CG; PLCB4; TRAF6; NFKBIA
    Hepatitis B NFKBIA; IRF7; IFNA17; PIK3R2; IFNA7; PIK3CD; TBK1; PIK3R3; PIK3R5; CCNA1
    Pathways in cancer DAPK2; MMP9; ROCK2; GSTP1; RALB; FGF3; PTCH1; ERBB2; LAMC2; BRCA2
    Colorectal cancer TCF7; DCC; TGFB3; CCND1; PIK3R5; BRAF; AKT1; RAC2; AKT2; MAPK8
    Pancreatic cancer PIK3CD; TGFBR2; MAP2K1; STAT3; RAF1; TGFB1; CCND1; BCL2L1; TGFB3; SMAD2
    Chronic myeloid leukemia STAT5A; TGFBR1; AKT1; CTBP2; TGFBR2; PIK3R1; HRAS; MAP2K2; SOS1; SHC2
    Inflammatory bowel disease (IBD) HLA-DQA2; HLA-DMA; HLA-DRA; IFNG; SMAD3; IL12A; IFNGR1; TGFB2; HLA-DPB1; TGFB3

    SMAD3 has several biochemical functions, for example, R-SMAD binding, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD3 itself. We selected most functions SMAD3 had, and list some proteins which have the same functions with SMAD3. You can find most of the proteins on our site.

    Function Related Protein
    R-SMAD binding SMAD2; ZEB2; CTNNB1; MYOCD; RANBP3; C18orf1; PAX6; MEN1; SMAD3; ZC3H3
    RNA polymerase II activating transcription factor binding ISL1; HNF4A; TBX6; CTNNB1; SMAD3; EP300; HEY2; NFE2L2; HIPK2; JUN
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ZFP639; NEUROG3; TFE3; SKIL; JUNBB; RFX8; NR1H2; GZF1; RFX1; CC2D1A
    bHLH transcription factor binding MAP3K10; SP1; USF2; IKZF4; ISL1; HAND1; TCF21; RUNX2; SMAD3; ASCL1
    beta-catenin binding TBL1XR1; DACT2; SHROOM2; CALCOCO1; NF2; SLC9A3R2; SALL1; VCL; SOX9; PTPRU
    chromatin DNA binding HDAC3; ACTN4; HIST1H1B; AASS; HIST1H1D; FOXO3; EP300; INSM1A; APEX1; MYOG
    co-SMAD binding FOXH1; SMAD1; TGIF1; SMAD6; SMAD3; TRIM33; USP9X; CITED1; GATA4; SMAD2
    collagen binding Itga10&Itgb1; LRRC15; TGFBI; ITGA3; USH2A; CTSK; Pdgfa&Pdgfb; LACRT; ADAM9; PDGFB
    core promoter proximal region sequence-specific DNA binding SMAD3; GATA3; DMRTC2; SP3A; CXXC1; MIXL1; SP3; KLF1; PAX2; DMRTC1B
    enhancer binding SMAD3; SP1; ARNT; MESP1; ELL3; FOXH1; SMAD2; TIPARP; SOX9; RAI1
    identical protein binding STXBP1; CST3; NME1; FTL; DYNLT1F; NCAM1; CD74; HJURP; MRFAP1L1; GNPNAT1
    phosphatase binding CARHSP1; PPP1R18; CRY1; TPRN; SYTL2; DLG1L; PPP1R21; MAPK1; CSRNP2; WNK1
    protein binding AEBP2; MEP1B; CD48; LRRC4C; MYBBP1A; SLN; EIF4A3; MEOX1; ANTXR1; ZNF580
    protein heterodimerization activity GM5506; SPTAN1; SIM2; H2AFZ; NAE1; CENPA; HIST1H4J; CYBB; CREB3L3; DR1
    protein homodimerization activity BAK1; SQSTM1; CADM1A; MID2; ADSSL1; TERF1; GRPEL1; FGFR2; HLCS; APOA2
    protein kinase binding MAP2K7; HSPB1; RELA; ADAM10; MSN; MAP3K1; JTB; Fert2; CAV2; PIH1D1
    sequence-specific DNA binding DRGX; IRX5B; SMAD3A; HOXC12B; TA; NR5A1A; TBX3; HOXB8A; FOXD4L1; SOX6
    transcription factor activity, RNA polymerase II core promoter sequence-specific HEYL; MEF2C; HEY1; HEY2; NKX3; TFAP2B; SMAD3; PAX7; MAX
    contributes_to transcription factor activity, protein binding SMAD3; SMAD4
    transcription factor activity, sequence-specific DNA binding ETV6; TFAM; FOXH1; KAT7B; YBX1; ZKSCAN3; TFDP2; DRAP1; HNF1A; TAF4B
    contributes_to transcription factor activity, sequence-specific DNA binding SMAD3; SMAD4; VDR; VDRA; SMAD2; TAF7; TAF12; FOXH1; TAF10; HNRNPAB
    transcription factor binding SMARCD3; MED6; RPS3; E2F2; NKX2-1; REST; MDFIC; HES2; HEYL; KAT2A
    transcription regulatory region DNA binding ZNF613; CTCFL; SMARCA2; DHX36; FOXI1; SIX1; SOX5; RELA; MZF1; NKX2-1
    transforming growth factor beta receptor binding GDF3; INHBA; SMAD3; BMP15; BMP8B; SMURF2; MSTNA; LRG1; GDF10; BMP5
    transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity SMAD9; SMAD1; SMAD2; SMAD3
    ubiquitin binding NEDD4; FAF2; KIF18A; OTUB1A; MARK4; NSFL1C; BRAP; TRP53INP2; SHRPRBCK1R; USP5
    ubiquitin protein ligase binding ARRB1; PPARGC1A; CHEK2; SCN5A; GABARAPL2; HSPD1; DBT; SQSTM1; USP25; PER3
    zinc ion binding TRIM45; TRIM22; GTF2H2C; USP39; USP22; RNF220A; TRIM55B; BRF1; ZMYM5; PGGT1B

    SMAD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD3.

    SMAD4; SKI

    Smithrithee, R; Niyonsaba, F; et al. Human beta-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes. JOURNAL OF DERMATOLOGICAL SCIENCE 77:46-53(2015).
    McMillin, M; Galindo, C; et al. Gli1 activation and protection against hepatic encephalopathy is suppressed by circulating transforming growth factor beta 1 in mice. JOURNAL OF HEPATOLOGY 61:1260-1266(2014).

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