SMAD3

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SMAD3

Official Full Name SMAD family member 3
Background The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]
Synonyms SMAD3; SMAD family member 3; LDS3; LDS1C; MADH3; JV15-2; HSPC193; HsT17436; mothers against decapentaplegic homolog 3; mad3; hMAD-3; hSMAD3; MAD homolog 3; mad homolog JV15-2; mad protein homolog; mothers against DPP homolog 3; SMA- and MAD-related protein 3; SMAD, mothers against DPP homolog 3; MAD, mothers against decapentaplegic homolog 3;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • MBP
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SMAD3-1094H Recombinant Human SMAD Family Member 3, GST-tagged E.coli GST
    Human SMAD3-1918H Recombinant Human SMAD3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SMAD3-295H Recombinant Human SMAD3 protein, GST-tagged E.coli GST
    Human SMAD3-304H Recombinant Human SMAD3 Protein, His-tagged E.coli His
    Human SMAD3-31190TH Recombinant Human SMAD3, His-tagged E.coli His
    Human SMAD3-31191TH Recombinant Human SMAD3 E.coli N/A
    Human SMAD3-326H Recombinant Human SMAD3 protein, His/MBP-tagged E.coli His/MBP
    Human SMAD3-327H Recombinant Human SMAD3 protein, His/MBP-tagged E.coli His/MBP
    Human SMAD3-4599H Recombinant SMAD Family Member 3, His-tagged Human His
    Human SMAD3-4788H Recombinant Human SMAD3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SMAD3-6915H Recombinant Human SMAD Family Member 3, His-tagged E.coli His
    Mouse SMAD3-001MCL Recombinant Mouse SMAD3 cell lysate Insect Cell N/A
    Mouse Smad3-305M Recombinant Mouse Smad3 Protein, His-tagged E.coli His
    Mouse SMAD3-532M Recombinant Mouse Smad3, His-GST tagged Insect Cell GST
    Mouse Smad3-5951M Recombinant Mouse Smad3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat SMAD3-5608R Recombinant Rat SMAD3 Protein Mammalian Cell His
    Rhesus Macaque SMAD3-4331R Recombinant Rhesus monkey SMAD3 Protein, His-tagged Mammalian Cell His
    Chicken SMAD3-6045C Recombinant Chicken SMAD3 Mammalian Cell His

    SMAD3 involved in several pathways and played different roles in them. We selected most pathways SMAD3 participated on our site, such as FoxO signaling pathway, Cell cycle, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway PIK3R2; PDPK1B; BRAF; AKT1; TGFB1; PIK3R3A; INSRA; MAPK14A; PRKAG3; AKT3A
    Cell cycle DMC1; NCAPG2; CEP63; TUBGCP2; TMPO; ESPL1; LIN54; SPDL1; ANAPC13; AHCTF1
    Endocytosis KIT; HRAS; LDLRAP1B; AP2M1B; RAB5B; CAV1; RAB35; WASH1; VPS37A; TFR1A
    Wnt signaling pathway WNT2B; RAC1B; PRKCA; PSEN1; MYCB; CAMK2G; SMAD4; CUL1; PRICKLE1; WNT5A
    TGF-beta signaling pathway BMP7B; INHBAB; AMHR2; ID2A; SPAW; FSTA; GDF6A; ACVR1B; SMAD3A; CUL1B
    Hippo signaling pathway FZD10; FZD3; RASSF1; BMP8B; ID2; YAP1; CCND3; NF2; DVL3; AREG
    Adherens junction PVRL1B; TGFBR1A; WASF2; BAIAP2A; RAC3B; ACTN3B; PTPRFB; RHOAA; TCF7; INSRA
    Signaling pathways regulating pluripotency of stem cells PAX6; HESX1; WNT6; IL6ST; FZD2; RAF1; NODAL; WNT7B; ACVR2B; BMP2
    Chagas disease (American trypanosomiasis) PLCB2; IL6; TRAF6; AKT2; Il2; MAPK8; MYD88; IL12B; PIK3R5; IL1B2
    Hepatitis B RB1; TRP53; PIK3R3; CASP8; MAPK9; IRF3; MAPK8; VDAC3; CREB3L3; TGFB1
    HTLV-I infection Pdgfa&Pdgfb; IKBKG; HLA-DQB1; ATM; Adcy4; ITGAL; FOS; VDAC1; PDGFA; VDAC3
    Pathways in cancer MAP2K2; CBLC; CXCL12; GNGT2; MLH1; PIK3CA; APC; TGFBR1; GNAI3; WNT1
    Colorectal cancer AKT1; MSH2; MAPK1; MAPK10; BIRC5; PIK3CD; PIK3CA; Casp3; TP53; TGFB2
    Pancreatic cancer TGFB1; STAT3; VEGFA; MAPK8; AKT1; RAC1; NFKB1; TRP53; RALBP1; ARHGEF6
    Chronic myeloid leukemia AKT2; MAPK3; KRAS; TGFB3; HDAC2; SHC2; PTPN11; TRP53; CTBP2; CRK
    Inflammatory bowel disease (IBD) IL12RB1; Il23a; Il12b; TGFB3; HLA-DQB1; SMAD2; IFNG; SMAD3; H2-AA; IL12A; FOXP3

    SMAD3 has several biochemical functions, for example, R-SMAD binding, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD3 itself. We selected most functions SMAD3 had, and list some proteins which have the same functions with SMAD3. You can find most of the proteins on our site.

    Function Related Protein
    R-SMAD binding SMURF1; FOS; ANKRD1; TRIM33; MEN1; ZC3H3; AXIN1; PPM1A; SMAD3; MYOCD
    RNA polymerase II activating transcription factor binding MAD2L2; PITX2; EGR2; NHLH2; HNF4A; SIN3A; IFI27; EP300; T; RB1
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ZKSCAN3; ESR1; SKIL; ISL1; PITX3; ATF3; PATZ1; E2F8; FEZF1; IRF4
    bHLH transcription factor binding TCF21; USF1; HAND1; TCF3; TCF3A; RUNX2; USF2; SOX9; ISL1; SIRT1
    beta-catenin binding PTPRK; PTPRJ; SOX9; CDH2; CALCOCO1; TBL1XR1; PSEN1; SOX17; DACT2; KDM6B
    chromatin DNA binding BCL6; RARA; INSM1B; NKAP; HIST1H1D; EZH2; HIST1H1A; SMAD3; ACTN4; PRDM14
    co-SMAD binding CITED1; SMAD6; SMAD3; FOXH1; TRIM33; TGIF1; SMAD1; USP9X; GATA4; SMAD2
    collagen binding SERPINH1A; CHADL; SMAD4; SERPINH1B; ITGA10; CD44; MMP9; Itga10&Itgb1; CTSL1; MMP13
    core promoter proximal region sequence-specific DNA binding DMRTC1C2; DMRT2B; SP3; DMRTC1B; SP3A; DMRT3A; UHRF1; CREBBP; CXXC1; TFAP2A
    enhancer binding TCF3; RAI1; SMAD3; SOX9; AHR; ELL3; SP1; ARNT; TCF12; FOXH1
    identical protein binding ACTG1; CBS; ESR1; CSNK2B; COL2A1; NIF3L1; FBP1; SNCAIP; NELL2; CLDN8
    phosphatase binding SPRED1; PPP1R27; DYSFIP1; SH2D4A; KIAA0649; SH3YL1; MAGI2; SMAD3; PPARA; DLG1L
    protein binding CDAN1; PNKP; KIF2C; SLC7A11; TRIM25; ATP6V0A2; TEX14; MYB; MXD1; SCARA5
    protein heterodimerization activity VAPA; RAF1; KCNH1; SUPT3H; NR4A2; SLC51B; IKZF4; TAP1; SYT10; MYO5A
    protein homodimerization activity IKZF4; SYNDIG1; AGR2; UNC13A; ABCB10; ATG7; HELT; HINT2; NKX2-5; CHRNA7
    protein kinase binding PLK1S1; SPRED1; PTPRJ; NEFH; CDK5; TPRKB; DNAJC3; MAML1; RFFL; AURKA
    sequence-specific DNA binding IKZF3; HSFX1; POU2F3; AHR2; DMRT2A; HIVEP3; FEV; HOXB9A; ALX3; IRX5A
    transcription factor activity, RNA polymerase II core promoter sequence-specific MEF2C; SMAD3; HEY1; HEYL; MAX; NKX3; PAX7; HEY2; TFAP2B
    contributes_to transcription factor activity, protein binding SMAD4; SMAD3
    transcription factor activity, sequence-specific DNA binding FOXH1; ZNF167; FBXW7; FOXC1; TBX2B; THRAA; FOXG1B; HLF; NR2F6; ENO1
    contributes_to transcription factor activity, sequence-specific DNA binding SMAD2; NFE2L2A; SOX19A; FOXH1; RXRA; TAF6; VDRB; VDRA; SMAD4; MAFGB
    transcription factor binding PPP1R13BA; DACT2; WWP2; RNF4; NLRP3; NFKBIA; FOXA3; CDK9; UBA2; PARP1
    transcription regulatory region DNA binding H2AFY2; STAT3; SNCA; ZNF821; MLL1; HOXA13; ZNF335; CITED1; PAX8; CARM1
    transforming growth factor beta receptor binding INHBA; INHBAA; GDF10B; GDF6B; BMP7; INHBE; BMP8B; MSTN; GDF1; INHA
    transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity SMAD3; SMAD1; SMAD2; SMAD9
    ubiquitin binding PARK2; USP13; CRY1; AUP1; CXCR4; OTUB1; C6orf106; TOM1L1; CRY2; OTUB1A
    ubiquitin protein ligase binding ARRB2; PDE4D; PIAS1; CASP8; JKAMP; CUL3A; UBE2W; PRKAR2B; CUL3B; RNF20
    zinc ion binding MSRB3; RERE; LMX1BA; MARCH5L; P2RX2; APOBEC2A; HNF4A; HDAC4; FHL3B; RXRGA

    SMAD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD3.

    SMAD4; SKI

    Smithrithee, R; Niyonsaba, F; et al. Human beta-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes. JOURNAL OF DERMATOLOGICAL SCIENCE 77:46-53(2015).
    McMillin, M; Galindo, C; et al. Gli1 activation and protection against hepatic encephalopathy is suppressed by circulating transforming growth factor beta 1 in mice. JOURNAL OF HEPATOLOGY 61:1260-1266(2014).

    TGF

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