SMARCA2

  • Official Full Name

    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
  • Overview

    The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma;protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate;transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of;the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of;genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this;gene, which contains a trinucleotide repeat (CAG) length polymorphism.
  • Synonyms

    SMARCA2;SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2;SNF2L2;probable global transcription activator SNF2L2;BAF190;BRM;hBRM;hSNF2a;SNF2;SNF2LA;Sth1p;SWI2;BAF190B;SNF2-alpha;protein brahma h

Recombinant Proteins

  • Human
  • Zebrafish
  • Chicken
  • Insect Cells
  • E.coli
  • Mammalian Cells
  • Yeast
  • Flag
  • His
  • GST
  • Non
  • SUMO
  • Avi
  • MBP
Cat.# Product name Source (Host) Species Tag Protein Length Price
SMARCA2-01H Recombinant Human SMARCA2 Protein, His-FLAG-tagged Insect Cells Human Flag&His
SMARCA2-2657H Recombinant Human SMARCA2 protein, His-tagged E.coli Human His 1-272 aa
SMARCA2-71H Active Recombinant Human SMARCA2, His&FLAG-tagged E.coli Human Flag&His 1367-1511 a.a.
SMARCA2-159H Recombinant Human SMARCA2, GST-tagged E.coli Human GST 1367-1511 a.a.
SMARCA2-194H Recombinant Human SMARCA2 Protein, His-tagged E.coli Human His 1367-1511
SMARCA2-195H Recombinant Human SMARCA2 Protein, GST-tagged E.coli Human GST 1367-1511
SMARCA2-196H Recombinant Human SMARCA2 Protein, His-tagged E.coli Human His 1367-1493
SMARCA2-3920Z Recombinant Zebrafish SMARCA2 Mammalian Cells Zebrafish His
SMARCA2-6696C Recombinant Chicken SMARCA2 Mammalian Cells Chicken His
Kit-1866 SMARCA2 Inhibitor Screening Assay Kit Non
SMARCA2-11H Recombinant Human SMARCA2 Protein (636-1131), N-FLAG tagged Insect Cells Human Flag 636-1131
SMARCA2-13H Recombinant Human SMARCA2 Protein (1367-1511), N-GST tagged E.coli Human GST 1367-1511
SMARCA2-1523H Recombinant Human SMARCA2 Protein (700-1216 aa), His-tagged Yeast Human His 700-1216 aa
SMARCA2-194HB Recombinant Human SMARCA2 Protein, His-tagged, Biotinylated E.coli Human His 1367-1511 aa
SMARCA2-3508H Recombinant Human SMARCA2 protein, His-SUMO-tagged E.coli Human His&SUMO 700-1216aa
SMARCA2-5654H Recombinant Human SMARCA2 protein, MBP&His-Avi-tagged, Biotinylated E.coli Human Avi&His&MBP 700-1216aa

    Involved Pathway

    SMARCA2 involved in several pathways and played different roles in them. We selected most pathways SMARCA2 participated on our site, such as C-MYB transcription factor network,Chromatin modifying enzymes,Chromatin organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMARCA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    E2F transcription factor network RYBP,CBX5,CES3,E2F6,CDKN2C,UXT,DHFR,RBBP8,HBP1,MYBL2
    RMTs methylate histone arginines PBRM1L,PBRM1,SMARCC1B,COPRS,SMARCC2,PRMT7,SMARCB1B,SMARCD3,SMARCD1,SMARCA4
    Regulation of Androgen receptor activity SPDEF,NR2C1,SRY,APPBP2,KAT7,SENP1,NR0B1,HOXB13,GATA2,TRIM24
    C-MYB transcription factor network CDKN1B,YEATS4,ADA,CEBPB,ADORA2B,PPID,LECT2,MYC,MYOD1,COL1A2
    Chromatin organization ARID2,KDM2A,KAT6A,PADI2,KDM4D,EED,KAT8,PHF8,MSL1,KDM4C
    Chromatin modifying enzymes ING5A,RBB4L,USP22,SETD3,KAT7,MORF4L2,KAT5,SAP130,SAP18,ING4
    RB in Cancer RABIF,HLTF,FAF1,RBP1,TOP2A,HMGB2,DCK,ANLN,PRMT2

    Protein Function

    SMARCA2 has several biochemical functions, for example, ATP binding,DNA-dependent ATPase activity,RNA polymerase II transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMARCA2 itself. We selected most functions SMARCA2 had, and list some proteins which have the same functions with SMARCA2. You can find most of the proteins on our site.

    Function Related Protein
    histone binding USP3,HIST3H3,SNCA,PRMT7,ATRX,HIST1H4A,HIST2H3C,HIST1H3H,SMARCA4A,Ctsl
    RNA polymerase II transcription coactivator activity HYAL2,POU3F1,MYOCD,PRRX1,POU3F2,PITX2,ISL1,SOX4,SMARCA4,MEF2A
    transcription coactivator activity SAP130,PMF1,TADA2A,GABPA,TAF5L,ARID1A,KAT2A,SIX3,JUNBB,YAP1
    protein binding CFTR,GRB7,UBASH3A,GGA2,RBL2,KPNA4,TCEB3,PI4KB,PLEKHO1,CDON
    transcription regulatory region DNA binding KLF1,NFKB1,ZFP382,CARM1,TP53,SOX6,JUN,MEN1,BASP1,KLF15
    chromatin binding SP140L,SKOR2,JARID2B,SUZ12,SMC1A,NAP1L2,SMAD6,FABP1,HOXC13,STAT5B
    ATP binding ATP2B3B,NOLC1,STK25B,DAPK3,NEK11,MARK1,MINK1,AARSD1,PRKAA1,KIFC3
    helicase activity PIF1,HELLS,TDRD9,SMARCA4,DDX58,RAD54L,DDX19B,DHX37,WRN,ATRX
    DNA-dependent ATPase activity DHX36,IGHMBP2,MSH5,ERCC6,TTF2,MSH2,DMC1,RAD51C,XRCC2,CDK7

    Interacting Protein

    SMARCA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMARCA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMARCA2.

    tat_hv112;ARID1A;ARID1B;MECP2;KHDRBS1

    Resources

    References

    • Lee, D; Moon, S; et al. NMR and Fluorescence Studies of DNA Binding Domain of INI1/hSNF5. BULLETIN OF THE KOREAN CHEMICAL SOCIETY 35:2753-2757(2014).
    • Zhang, LY; Ma, P; et al. Expression profiling of the RPE in zebrafish smarca4 mutant revealed altered signals that potentially affect RPE and retinal differentiation. MOLECULAR VISION 20:56-72(2014).

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