SMARCB1
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Official Full Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -
Overview
The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
SMARCB1;SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1;RDT;INI1;SNF5;Snr1;BAF47;MRD15;RTPS1;Sfh1p;hSNFS;SNF5L1;SWNTS1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;hSNF5;SNF5 homolog;BRG1-associated factor 47;integrase interactor 1 protein;malignant rhabdoid tumor suppressor;SWI/SNF-related matrix-associated protein;sucrose nonfermenting, yeast, homolog-like 1
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cells
- Yeast
- HEK293
- Insect Cells
- GST
- His
- Non
- SUMO
- DDK
- Myc
- Avi
- Fc
Involved Pathway
SMARCB1 involved in several pathways and played different roles in them. We selected most pathways SMARCB1 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,RMTs methylate histone arginines, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMARCB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of retinoblastoma protein | ATF7,GSC,ELF1,CBX4,MYOD1,BGLAP,CKM,BRD2,AATF |
| Chromatin organization | AEBP2,C3orf75,TAF6L,KANSL2,SMARCA4,ATXN7L3,PRMT7,PBRM1,ZZZ3,MORF4L1 |
| TNF-alpha/NF-kB Signaling Pathway | KTN1,DCAF7,NR2C2,PFDN2,PAPOLA,PPP1R13L,TIFA,CSNK2A1P,NKIRAS1,KIAA1967 |
| RMTs methylate histone arginines | PBRM1L,SMARCA2,PBRM1,SMARCC2,SMARCC1B,PRMT7,SMARCD3B,SMARCE1,SMARCD1,ARID1A |
| Chromatin modifying enzymes | CARM1,COPRS,KDM5C,DNMT3A,TADA2B,KDM2A,KDM5A,GATAD2B,SMYD2A,PHF2 |
Protein Function
SMARCB1 has several biochemical functions, for example, DNA binding,RNA polymerase I CORE element sequence-specific DNA binding,contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMARCB1 itself. We selected most functions SMARCB1 had, and list some proteins which have the same functions with SMARCB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| p53 binding | TRIM24,ZFP346,CREBBP,NUAK1,BANP,GATA1,SETD7,ZNF385D,ZMAT4,USP10 |
| contributes_to nucleosomal DNA binding | HDAC2,SMARCA4,MTA2,ACTL6A,SMARCC2,HDAC1,SMARCC1,RBBP4,GATAD2B,SMARCE1 |
| RNA polymerase I CORE element sequence-specific DNA binding | TAF1C,TAF1B,SMARCA4,BAZ2A,EFCAB11,PIH1D1,RRN3 |
| contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding | MTA2,ACTL6A,CHD4,SMARCE1,SMARCA4,SMARCC2,MBD3,RBBP4,GATAD2B,SMARCC1 |
| contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding | HDAC2,HDAC1,MBD3,CHD4,RBBP4,SMARCC1,SMARCE1,GATAD2B,ACTB,MTA2 |
| transcription coactivator activity | PARK7,PPARGC1A,BCL10,PMF1,CTBP2,RARA,GMEB2,TADA3,NPM1,SUPT7L |
| Tat protein binding | GABARAPL1,DLL1,MDFIC,ACTB,SMARCA4,NPM1,TRIM32 |
| DNA binding | MUS81,ZNF563,RNF11,STAT2,HOXD9A,DMRT2B,ENG1A,ISL1L,TIGD6,TSHZ1 |
| protein binding | MYOM1,ZBTB7C,TCF3,ZCCHC12,STX3,FRAS1,CXCL14,KRTAP3-3,DYSFIP1,CRABP1 |
Interacting Protein
SMARCB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMARCB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMARCB1.
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References
- Yoshida, A; Asano, N; et al. Differential SALL4 immunoexpression in malignant rhabdoid tumours and epithelioid sarcomas. HISTOPATHOLOGY 66:252-261(2015).
- Bartelheim, K; Sumerauer, D; et al. Clinical and genetic features of rhabdoid tumors of the heart registered with the European Rhabdoid Registry (EU-RHAB). CANCER GENETICS 207:379-383(2014).
