SOD2

  • Official Full Name

    superoxide dismutase 2, mitochondrial

  • Overview

    This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Synonyms

    SOD2; superoxide dismutase 2, mitochondrial; IPOB; MNSOD; MVCD6; superoxide dismutase [Mn], mitochondrial; indophenoloxidase B; Mn superoxide dismutase; mangano-superoxide dismutase; manganese-containing superoxide dismutase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Macaca Fascicularis
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SOD2-1568H Recombinant Human SOD2 protein, His-tagged E.coli His
Human SOD2-30343TH Recombinant Human SOD2, His-tagged E.coli His
Human SOD2-1039H Recombinant Human SOD2 E.coli N/A
Human SOD2-31475TH Recombinant Human SOD2 E.coli N/A
Human SOD2-1636H Recombinant Human Superoxide Dismutase 2, Mitochondrial, GST-tagged E.coli GST
Human SOD2-738H Recombinant Human SOD2, MYC-DDK-tagged HEK293 Myc/DDK
Human SOD2-330H Recombinant Human SOD2 protein, His/MBP-tagged E.coli His/MBP
Human SOD2-1181H Recombinant Human SOD2 protein E.coli N/A
Human SOD2-329H Recombinant Human SOD2 protein, His/MBP-tagged E.coli His/MBP
Human SOD2-1574HCL Recombinant Human SOD2 293 Cell Lysate HEK293 N/A
Human SOD2-1575HCL Recombinant Human SOD2 293 Cell Lysate HEK293 N/A
Human SOD2-06H Recombinant Human SOD2 Protein E.coli
Human SOD2-062H Recombinant Human SOD2 Protein, N-His-tagged E.coli N-His
Human SOD2-2070H-B Recombinant Human SOD2 Protein Pre-coupled Magnetic Beads HEK293
Human SOD2-355H Recombinant Human SOD2 protein, His-tagged E.coli His
Human PDE2A-145H Recombinant Human SOD2 Protein E. coli
Human SOD2-2681H Recombinant Human SOD2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SOD2-2513H Recombinant Human SOD2 Protein (Lys25-Lys222), His tagged E.coli His
Human SOD2-2070H Recombinant Human SOD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SOD2-1397HFL Recombinant Full Length Human SOD2 Protein, C-Flag-tagged Mammalian cells Flag
Mouse Sod2-56M Recombinant Mouse Sod2, His-tagged E.coli His
Mouse SOD2-15750M Recombinant Mouse SOD2 Protein Mammalian Cell His
Mouse SOD2-8569M Recombinant Mouse SOD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SOD2-8569M-B Recombinant Mouse SOD2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Sod2-6041M Recombinant Mouse Sod2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Sod2-7342M Recombinant Mouse Sod2 Protein, His-tagged E.coli His
Rat SOD2-5667R Recombinant Rat SOD2 Protein Mammalian Cell His
Rat Sod2-1569R Recombinant Rat Sod2 protein, His-tagged E.coli His
Rat Sod2-34R Recombinant Rat Sod2, His-tagged E.coli His
Rat SOD2-5326R Recombinant Rat SOD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SOD2-5326R-B Recombinant Rat SOD2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey SOD2-957C Recombinant Cynomolgus SOD2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey SOD2-700C-B Recombinant Cynomolgus Monkey SOD2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey SOD2-700C Recombinant Cynomolgus Monkey SOD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Macaca Fascicularis SOD1-02H Recombinant Cynomolgus SOD1 Protein, His-tagged E.coli His
Rhesus Macaque SOD2-4406R Recombinant Rhesus monkey SOD2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SOD2-4222R Recombinant Rhesus Macaque SOD2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SOD2-4222R-B Recombinant Rhesus Macaque SOD2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SOD2-10339Z Recombinant Zebrafish SOD2 Mammalian Cell His
Chicken SOD2-5785C Recombinant Chicken SOD2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SOD2 Related Articles
  • SOD2 Related Research Area

SOD2 involved in several pathways and played different roles in them. We selected most pathways SOD2 participated on our site, such as FoxO signaling pathway, Peroxisome, Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FoxO signaling pathwayTGFB3;SKP2;FBXO25;GRM1;IGF1;AKT1;NRAS;STAT3;GRB2B
PeroxisomeACOX3;PEX1;ACSL4B;PEX14;ABCD1;NUDT12;ECH1;ACSL3;FAR2
Huntingtons diseaseUCP1;MT-ATP6;COX7A1;TBP;UQCRC2;NDUFV1;SLC25A5;NDUFA2;TP53

SOD2 has several biochemical functions, for example, identical protein binding, manganese ion binding, superoxide dismutase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOD2 itself. We selected most functions SOD2 had, and list some proteins which have the same functions with SOD2. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingBTK;TFRC;HAPLN2;SH3GL1;FGFR1;SFRP1;SDF4;PLN;NISCH
manganese ion bindingMTPAP;GYLTL1B;ATP2C1;XPNPEP1;ABL2;SLC11A2;FAM20C;B4GALT7;ME1
superoxide dismutase activityNQO1;CCS;PRNPA;SOD2;SOD1;SOD3A

SOD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOD2.

AURKA; RIPK2; SMARCA5; EIF1B; CST4; CST1; AMY1B; P4HB; MYH8; HSP90B1; MCC; MPG; HLA-B; VHL; RPL21; SMARCA2; ARF6; SCRN1

Kang, PT; Chen, CL; et al. Increased mitochondrial prooxidant activity mediates up-regulation of Complex I S-glutathionylation via protein thiyl radical in the murine heart of eNOS(-/-). FREE RADICAL BIOLOGY AND MEDICINE 79:56-68(2015).
Kang, PT; Chen, CL; et al. BCNU-induced gR2 DEFECT mediates S-glutathionylation of Complex I and respiratory uncoupling in myocardium. BIOCHEMICAL PHARMACOLOGY 89:490-502(2014).
  • Q&As
  • Reviews

Q&As (7)

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What are the current research directions regarding SOD2? 08/12/2021

Current research on SOD2 focuses on understanding its role in different disease contexts and identifying potential therapeutic targets. Investigations are underway to elucidate the molecular mechanisms underlying SOD2 regulation, its involvement in age-related diseases, and the development of novel strategies to enhance SOD2 activity for therapeutic purposes. Additionally, studies are exploring the interplay between SOD2 and other cellular processes, aiming to uncover new insights into its biological functions.

What therapeutic strategies target SOD2 for disease treatment? 11/06/2020

Several approaches have been explored to enhance SOD2 activity as a potential therapeutic strategy. These include the use of small molecule activators, such as resveratrol and melatonin, which can upregulate SOD2 expression and improve cellular antioxidant defense. Additionally, gene therapy approaches aiming to increase SOD2 levels or activity have shown promise in preclinical studies.

How does SOD2 contribute to cellular senescence and aging? 10/23/2020

As cells age, the expression and activity of SOD2 decline, resulting in increased levels of reactive oxygen species (ROS) and oxidative damage. The accumulation of ROS can promote cellular senescence, a state of irreversible growth arrest. SOD2 plays a crucial role in mitigating ROS-mediated DNA damage and preserving cellular integrity, thus influencing the aging process.

How is the expression of SOD2 regulated? 09/25/2020

The expression of SOD2 is regulated by various transcription factors, including nuclear factor erythroid 2-related factor 2 (NRF2) and forkhead box O3 (FOXO3). These transcription factors bind to the promoter region of the SOD2 gene and initiate its transcription. Additionally, post-translational modifications, such as acetylation and phosphorylation, can also modulate the activity and stability of SOD2.

What is the significance of SOD2 polymorphisms in disease susceptibility? 02/28/2019

Certain genetic variations or polymorphisms in the SOD2 gene have been associated with altered enzyme activity and increased susceptibility to certain diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. These polymorphisms can affect the antioxidant capacity of SOD2, leading to an imbalance between reactive oxygen species generation and scavenging, thereby contributing to disease pathogenesis.

What is the primary function of SOD2 in cellular physiology? 11/17/2018

SOD2, also known as mitochondrial superoxide dismutase, is an enzyme responsible for the dismutation of superoxide radicals into hydrogen peroxide and molecular oxygen within the mitochondria. This antioxidant activity helps to protect cells from oxidative stress and maintain redox homeostasis in the mitochondria.

How does SOD2 interact with other proteins and signaling pathways? 02/08/2016

SOD2 is known to interact with various proteins and signaling pathways to regulate cellular processes. For instance, SOD2 interacts with the nuclear factor kappa B (NF-κB) pathway, modulating its activity and downstream gene expression. SOD2 also interacts with other antioxidant enzymes, such as catalase and glutathione peroxidase, forming a coordinated antioxidant defense system within cells.

Customer Reviews (3)

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Reviews
01/10/2021

    It has earned my trust with its outstanding stability and reproducibility.

    10/04/2016

      After using this protein reagent, my protein gel electrophoresis results are notably clear, aiding in analysis and interpretation.

      07/30/2016

        Engaging confidently in academic discussions and collaborations with peers is possible due to this reagent's exceptional performance.

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