• Official Full Name

    SRY (sex determining region Y)-box 1

  • Overview

    This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. [provided by RefSeq, Jul 2008]
  • Synonyms

    SOX1; SRY (sex determining region Y)-box 1; transcription factor SOX-1; SRY-related HMG-box gene 1;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Silurana tropicalis
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SOX1-1566HCL Recombinant Human SOX1 293 Cell Lysate HEK293 N/A
Human SOX1-1537HFL Recombinant Full Length Human SOX1 Protein, C-Flag-tagged Mammalian cells Flag
Human SOX1-2072H-B Recombinant Human SOX1 Protein Pre-coupled Magnetic Beads HEK293
Human SOX1-2072H Recombinant Human SOX1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Sox1-6048M Recombinant Mouse Sox1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Silurana tropicalis sox1-5944S Recombinant Silurana tropicalis sox1 protein, His&His-tagged E.coli His&His 1-401aa
Chicken SOX1-5905C Recombinant Chicken SOX1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

SOX1 involved in several pathways and played different roles in them. We selected most pathways SOX1 participated on our site, such as Cardiac Progenitor Differentiation, Wnt Signaling Pathway NetPath, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cardiac Progenitor DifferentiationZFP42;TBX20;TBX5;IRX4;ROR2;LIN28A;LIN28B;NIPAL1;T
Wnt Signaling Pathway NetPathCSNK2A1P;NR5A1;CRYBB2;BRD7;SALL1;ROR2;TCF4;BCL9;ANKRD6

SOX1 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX1 itself. We selected most functions SOX1 had, and list some proteins which have the same functions with SOX1. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingTCF4;ETV2;DLX5;ELF4;NRL;PATZ1;EP300;TXK;NEUROD6
core promoter sequence-specific DNA bindingZFHX3;CRY1;CREM;SIRT1;ZFP750;TP53;PDX1;ESR1;SOHLH2
protein bindingOTUB1;EPAS1;BTBD1;LRPAP1;NHP2L1;KRT5;NOL9;KCND2;SLC25A10
transcription factor activity, sequence-specific DNA bindingIRF2;IRF3;DEAF1;TCEAL1;BCL3;AHCTF1;ELK4;ZFP14;ZNF397
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingNFIB;DLX5;FOXJ1;CEBPB;PLAG1;ZFP639;PITX1;ZIC3;LEF1

SOX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX1.


Research Area

Related articles

Horta, ES; Lennon, VA; et al. Neural Autoantibody Clusters Aid Diagnosis of Cancer. CLINICAL CANCER RESEARCH 20:3862-3869(2014).
Evoli, A; Liguori, R; et al. Italian recommendations for Lambert-Eaton myasthenic syndrome (LEMS) management. NEUROLOGICAL SCIENCES 35:515-520(2014).
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