• Official Full Name

    SRY (sex determining region Y)-box 6

  • Overview

    This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
  • Synonyms

    SOX6; SRY (sex determining region Y)-box 6; SOXD; HSSOX6; transcription factor SOX-6; SRY-box containing gene 6;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SOX6-1557HCL Recombinant Human SOX6 293 Cell Lysate HEK293 N/A
Human SOX6-5407H Recombinant Human SOX6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SOX6-5078H Recombinant Human SOX6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SOX6-2721H Recombinant Human SOX6 Protein, His-tagged E.coli N-His
Human SOX6-3555H Recombinant Human SOX6 protein, His-tagged E.coli His
Mouse Sox6-6058M Recombinant Mouse Sox6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Sox6-2090R Recombinant Rat Sox6 Protein, His-tagged E.coli N-His
Zebrafish SOX6-6616Z Recombinant Zebrafish SOX6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SOX6 Related Articles
  • SOX6 Related Research Area

SOX6 involved in several pathways and played different roles in them. We selected most pathways SOX6 participated on our site, such as Deactivation of the beta-catenin transactivating complex, Endochondral Ossification, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Deactivation of the beta-catenin transactivating complexTLE4;C;SOX4B;SRY;TLE2;BCL9L;SOX9A;PYGO2;SOX4A
Endochondral OssificationADAMTS5;PTH;COL10A1A;IFT88;DDR2;KIF3A;SOX5;RUNX2A;SOX9A
TCF dependent signaling in response to WNTZNRF3;RNF43;LGR6;HECW1;RSPO2;SOX9B;RSPO3;KREMEN1;SOX32

SOX6 has several biochemical functions, for example, DNA binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX6 itself. We selected most functions SOX6 had, and list some proteins which have the same functions with SOX6. You can find most of the proteins on our site.

Function Related Protein
protein bindingTAL2;KLHL38;PINX1;JAGN1;CYTIP;KRTAP23-1;TLR13;SLC9A1;KCNH1
protein heterodimerization activityRRAGC;GABPB2;SUPT5H;AXL;HIST1H2B7;CRLF1;TGFB1;PEF1;HIST1H4G
sequence-specific DNA bindingSOX30;SIX4B;CREB3L3L;RAX2;SPDEF;PRRX1B;HOXC11A;ZNF232;NKX1.2LA
transcription factor activity, sequence-specific DNA bindingTRP63;GBX2;ZNF812;ZNF207;DLX3;TCF7L1B;HSFY1;CREB1;ZFP35
transcription regulatory region DNA bindingTCF7;CTCFL;LEF1;DHX36;REST;H2AFY2;KLF11;TFAP4;CEBPA

SOX6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX6.


Rudrabhatla, P; Utreras, E; et al. Regulation of Sox6 by Cyclin Dependent Kinase 5 in Brain. PLOS ONE 9:-(2014).
Amano, K; Hata, K; et al. Sox9 Family Members Negatively Regulate Maturation and Calcification of Chondrocytes through Up-Regulation of Parathyroid Hormone-related Protein. MOLECULAR BIOLOGY OF THE CELL 20:4541-4551(2009).
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