SPRED1

  • Official Full Name

    sprouty-related, EVH1 domain containing 1
  • Overview

    The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).
  • Synonyms

    SPRED1;sprouty-related, EVH1 domain containing 1;sprouty-related, EVH1 domain-containing protein 1;FLJ33903;hSpred1;spred-1;suppressor of Ras/MAPK activation;EVH1/Sprouty domain containing protein;NFLS

Recombinant Proteins

  • Zebrafish
  • Mouse
  • Rhesus macaque
  • Chicken
  • Human
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • Avi
  • Fc
  • Myc
  • SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
SPRED1-12434Z Recombinant Zebrafish SPRED1 Mammalian Cells Zebrafish His
SPRED1-15925M Recombinant Mouse SPRED1 Protein Mammalian Cells Mouse His
SPRED1-4447R Recombinant Rhesus monkey SPRED1 Protein, His-tagged Mammalian Cells Rhesus macaque His
SPRED1-4465C Recombinant Chicken SPRED1 Mammalian Cells Chicken His
SPRED1-630H Recombinant Human sprouty-related, EVH1 domain containing 1, His-tagged E.coli Human His 1-444 a.a.
SPRED1-1498HCL Recombinant Human SPRED1 293 Cell Lysate HEK293 Human Non
SPRED1-4263R Recombinant Rhesus Macaque SPRED1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
SPRED1-4263R-B Recombinant Rhesus Macaque SPRED1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
SPRED1-4593H Recombinant Human SPRED1 protein, His-SUMO & Myc-tagged E.coli Human His&Myc&SUMO 2-444aa
SPRED1-8674M Recombinant Mouse SPRED1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
SPRED1-8674M-B Recombinant Mouse SPRED1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SPRED1 involved in several pathways and played different roles in them. We selected most pathways SPRED1 participated on our site, such as ARMS-mediated activation,Axon guidance,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPRED1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine Signaling in Immune system EIF4EB,CASPB,KLB,KPNA5,JAK1,PEA15,EIF4A1,TAB1,TNFSF13B,CRK
    DAP12 signaling FGF20A,FGF18B,FRS2B,PEBP1,DUSP5,SPRED3,DUSP9,CSF2RB,HBEGF,AGO2
    Downstream signal transduction SPTB,AGO3,SPTBN2,PHB,PAQR3A,SPNA1,GRB7,DUSP7,KBTBD7,CNKSR1
    Developmental Biology PEBP1,AP2A2,MYL12B,ADAM23,WDR83,DPYSL4,EVL,CACNG2,NRTN,TCF3A
    DAP12 interactions PEBP1,PAQR3A,GRAP2B,RASGRP4,DUSP10,LCP2A,MOV10,NRG4,SIGLEC15,SIRPB1
    Downstream signaling of activated FGFR1 DUSP9,KBTBD7,WDR83,SPNA1,PEA15,RASGEF1A,CNKSR1,IL17RD,RASGRP4,DUSP2
    Axon guidance PLXNA3,ABLIM1,EPHA7,SEMA3AA,CLTB,SEMA4A,PHB,EVL,CRMP1,SEMA3AB
    ARMS-mediated activation FGFR1B,FRS2A,PTPRA,AKAP9,CSK,CSF2,SPRED3,HBEGF,RASGRP4,MARK3

    Protein Function

    SPRED1 has several biochemical functions, for example, phosphatase binding,protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPRED1 itself. We selected most functions SPRED1 had, and list some proteins which have the same functions with SPRED1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding FZD6,MARK2,S100A16,LUM,TUBA1B,UCP3,MASP2,NCOR2,ARNTL1B,HESX1
    stem cell factor receptor binding KITLGB,Kitl,SPRED2,KITLG,KITLGA
    phosphatase binding SLC9A3R1,SH3YL1,KLRAQ1,SH2D4A,TPRN,CTSC,CRY2,ELFN2,CARHSP1,SYTL2
    protein kinase binding FBXO5,SPDYB,NBEA,Fert2,TUBB3,SPDYE2,ARHGEF7,PPP1CB,SKI,KAT2B
    protein serine/threonine kinase inhibitor activity SPRY2,CIB1,H2AFY,SPRED2

    Interacting Protein

    SPRED1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPRED1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPRED1.

    PPP1CA;ZDHHC17;SUV39H1;RCC1;CDKN1A;PPP1R7;TSC22D1;TTC19;FAM118B;OSGEP;DNAJB11;NAGK

    Resources

    References

    • Skelton, TS; Tejpal, N; et al. Allochimeric molecules and mechanisms in abrogation of cardiac allograft rejection. JOURNAL OF HEART AND LUNG TRANSPLANTATION 31:73-84(2012).

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