SPRED1
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Official Full Name
sprouty-related, EVH1 domain containing 1 -
Overview
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). -
Synonyms
SPRED1;sprouty-related, EVH1 domain containing 1;sprouty-related, EVH1 domain-containing protein 1;FLJ33903;hSpred1;spred-1;suppressor of Ras/MAPK activation;EVH1/Sprouty domain containing protein;NFLS
Recombinant Proteins
- Zebrafish
- Mouse
- Rhesus macaque
- Chicken
- Human
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- Avi
- Fc
- Myc
- SUMO
Involved Pathway
SPRED1 involved in several pathways and played different roles in them. We selected most pathways SPRED1 participated on our site, such as ARMS-mediated activation,Axon guidance,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPRED1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DAP12 signaling | NRG2A,PEBP1,NRG4,SPTA1,PAQR3B,FRS2A,THEM4,RASGRP4,DUSP6,LCP2A |
| DAP12 interactions | SPNA1,LAMTOR2,RASGRP4,NRG4,SIGLEC14,FGF20A,THEM4,JAK3,RASGEF1A,NRG2A |
| Axon guidance | PPP3CC,ITSN1,NADL1.1,SCN4A,CREB1B,GFRA2,NRG4,RHOC,LAMTOR2,EPHB4A |
| Downstream signal transduction | RASGRP4,THEM4,FGF8B,DUSP10,SPRED3,RASGEF1A,WDR83,PEA15A,AGO1,KBTBD7 |
| Downstream signaling of activated FGFR1 | PEA15,DUSP9,DUSP2,AGO2,SPTB,IL17RD,PHB,PEA15A,WDR83,RASGEF1A |
| Cytokine Signaling in Immune system | SPTBN2,EDAR,JAK1,IFIT14,GBP2,PTPRA,DUSP2,CSF2,DUSP7,TRIM22 |
| Developmental Biology | TRPC5,HIF3A,CSNK2A2,TCF12,MED10,GDNF,ITGB1B.1,CDK5R1B,NTN1A,CLTC |
| ARMS-mediated activation | DUSP7,WDR83,PAQR3B,PEBP1,KLB,EGFR,RASGRP4,NTF7,RASGRP1,HBEGF |
Protein Function
SPRED1 has several biochemical functions, for example, phosphatase binding,protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPRED1 itself. We selected most functions SPRED1 had, and list some proteins which have the same functions with SPRED1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | HDAC7A,FBXL8,EPHB1,SIM1,ZBTB7B,KLF6,NIP7,RLN3,GFPT2,PPP1R16B |
| stem cell factor receptor binding | KITLGB,SPRED2,Kitl,KITLG,KITLGA |
| protein serine/threonine kinase inhibitor activity | H2AFY,SPRED2,SPRY2,CIB1 |
| phosphatase binding | PPP1R27,CNST,KLRAQ1,TSC2,MAST2,CSRNP2,PPP1R32,SLC9A3R1,PPP1R26,ELFN2 |
| protein kinase binding | GCET2,RPS3,KAT2B,PLK1S1,USP37,NGFRAP1,SYK,ITGB2,SPDYE2,EEF2 |
Interacting Protein
SPRED1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPRED1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPRED1.
PPP1CA;ZDHHC17;SUV39H1;RCC1;CDKN1A;PPP1R7;TSC22D1;TTC19;FAM118B;OSGEP;DNAJB11;NAGK
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References
- Skelton, TS; Tejpal, N; et al. Allochimeric molecules and mechanisms in abrogation of cardiac allograft rejection. JOURNAL OF HEART AND LUNG TRANSPLANTATION 31:73-84(2012).
