SPRED2

  • Official Full Name

    sprouty-related, EVH1 domain containing 2

  • Overview

    SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced;activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 (PubMed 15465815)).

  • Synonyms

    SPRED2;sprouty-related, EVH1 domain containing 2;sprouty-related, EVH1 domain-containing protein 2;C79158;FLJ21897;FLJ31917;MGC163164;Spred 2;Sprouty protein with EVH 1 domain 2 related sequence;sprouty related EVH1 domain containing 2;Sprouty related protein with EVH 1 domain 2;zgc:77284;OTTHUMP00000202294;OTTHUMP00000202297;OTTHUMP00000225519;sprouty protein with EVH-1 domain 2, related sequence;Spred-2

Recombinant Proteins

  • Mouse
  • Rhesus macaque
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • E.coli
  • His
  • Non
  • T7
  • Avi
  • Fc

    Involved Pathway

    SPRED2 involved in several pathways and played different roles in them. We selected most pathways SPRED2 participated on our site, such as ARMS-mediated activation,Axon guidance,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPRED2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Downstream signaling of activated FGFR1 PAQR3B,RASGRP4,IL17RD,RASGEF1A,PAQR3A,PEA15,PTPRA,DUSP2,SPTA1,DUSP9
    Developmental Biology FGF18B,GDF1,DPYSL3,DCC,NRG2A,LEFTY1,CLTC,PAK4,ARPC1A,RHOC
    DAP12 interactions TREM1,GRAP2B,LAMTOR2,PHB,LCP2A,FGF20A,NRG4,RASGRP4,SIGLEC14,MARK3
    Cytokine Signaling in Immune system IFITM2,EIF4A1,TRIM6,EIF4A2,ARIH1,FGF20A,BST2,TRIM48,EIF4G1,OASL
    ARMS-mediated activation PSME3,PHB,WDR83,NEFLB,KIDINS220B,NRG2A,KLB,SPTB,SPRED3,FRS2
    Axon guidance EPHB3A,RAC3,ACTR2,MYL12B,JAK1,SPNA2,KCNQ2,ITSN1,ITGB1,ABLIM3
    DAP12 signaling THEM4,FGF18B,SPNA1,FGFR1B,LAMTOR2,FGF10B,IL17RD,HBEGF,JAK1,FRS2A
    Downstream signal transduction SPTBN2,FGF10B,PHB,PEA15,SPTB,KBTBD7,SPTA1,CNKSR1,FGF20A,SPRED3

    Protein Function

    SPRED2 has several biochemical functions, for example, protein binding,protein kinase binding,protein serine/threonine kinase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SPRED2 itself. We selected most functions SPRED2 had, and list some proteins which have the same functions with SPRED2. You can find most of the proteins on our site.

    Function Related Protein
    protein serine/threonine kinase inhibitor activity SPRED1,H2AFY,CIB1,SPRY2
    protein binding RAMP1,SET,SOCS7,GET4,FURIN,COL3A1,OIT3,DDIT4L,MNAT1,PPP1R12B
    protein kinase binding RPS19,CDK5,GRB7,TRAP1,YWHAZ,BORA,SFN,CDH2,NGFRAP1,SPDYA
    stem cell factor receptor binding KITLGA,SPRED1,Kitl,KITLG,KITLGB

    Interacting Protein

    SPRED2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPRED2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPRED2.

    TOP3B;SPG21;ZDHHC17;CBL

    Resources

    Research Area

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