SPTA1

  • Official Full Name

    spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
  • Overview

    Spectrin is a major constituent of the erythrocyte skeleton accounting for 25% of the total membrane protein and 75% of the cytoskeletal mass. Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton by associating with the cytoplasmic surface of the membrane by attachment to ankyrin. The membrane skeleton influences several cellular properties such as cell shape, restriction of mobility of the integral membrane protein exposed at the cell surface and transmembrane movement of phospholipids and cholesterol and organization of organelles. Spectrin is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. Mutations in spectrin result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.
  • Synonyms

    SPTA1;spectrin, alpha, erythrocytic 1 (elliptocytosis 2);spectrin alpha chain, erythrocyte;EL2;alpha-I spectrin;erythroid alpha-spectrin;HPP;HS3;SPH3;SPTA
Cat.# Product name Source (Host) Species Tag Protein Length Price
SPTA1-1389H Recombinant Human SPTA1, GST-tagged E.coli Human GST
SPTA1-114H Recombinant Human SPTA1 Protein, GST-tagged E.coli Human GST
SPTA1-4571H Recombinant Human SPTA1 protein, His-tagged Insect Cells Human His 53-474aa
SPTA1-4572H Recombinant Human SPTA1 protein, His-tagged Mammalian Cells Human His 53-474aa
SPTA1-532H Recombinant Human SPTA1 protein(53-474aa), His&Myc-tagged E.coli Human His&Myc 53-474aa

    Involved Pathway

    SPTA1 involved in several pathways and played different roles in them. We selected most pathways SPTA1 participated on our site, such as ARMS-mediated activation,Axon guidance,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPTA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Downstream signaling of activated FGFR1 RASGRP4,SPRED3,PEA15A,WDR83,CNKSR1,AGO2,MARK3,DUSP2,RASGEF1A,SPRED1
    Developmental Biology CEBPA,NRP1A,EFNA1,DPYSL4,JAK3,ACTR2B,KLB,PSPN,SHB,INSM1B
    Cytokine Signaling in Immune system IFIT12,DUSP9,CRKL,IFIT11,IFITM3,FGF10B,CSF2,EIF4A1,GBP1,RASGRP4
    Downstream signal transduction PTPRA,AGO2,PAQR3B,LAMTOR2,AGO3,WDR83,FRS3,SPRED1,CNKSR1,FRS2A
    Axon guidance FGF20A,NRG3,NRP1A,FGF8B,FES,SEMA4D,PEA15A,RHOGA,EPHB4B,TRPC5
    DAP12 signaling FGFR1B,FGF8B,GRAP2A,DUSP4,THEM4,FGF20A,DUSP6,GRAP2B,KBTBD7,SPTBN2
    ARMS-mediated activation NTF7,JAK1,FGF20A,DUSP2,JAK3,CSF2RA,AKAP9,FRS3,EGFR,DUSP1
    DAP12 interactions SIGLEC14,RASGRP4,NRG4,SIGLEC15,AGO3,IL17RD,TREM1,PHB,FGF10B,CSF2RA

    Protein Function

    SPTA1 has several biochemical functions, for example, actin filament binding,calcium ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPTA1 itself. We selected most functions SPTA1 had, and list some proteins which have the same functions with SPTA1. You can find most of the proteins on our site.

    Function Related Protein
    protein heterodimerization activity ADIPOR1,TBX18,TCF3,DMRT3A,BCL2L1,CASP8,TAF4B,CREB3L3,VOX,IRAK1
    actin filament binding TLN1,MYO18A,SVIL,ESPN,SCIN,USH1C,NEBL,CORO2A,ACTN2,WIPF1A
    structural constituent of cytoskeleton TUBB2B,ACTR3,TUBB,ADD3,TUBA8L3,TUBA3C,TUBGCP3,TUBA1C,TUBD1,MAPT
    protein binding PSMB3,OAS3,SGTB,EPB41L1,TCERG1,COPS6,TMSB10,CDK9,OPRL1,AIMP1
    calcium ion binding CALB2,PKD2L1,PRF1,PRRG2,CMLC1,UMODL1,PLCZ1,FBN1,PCDH1G30,EFCAB4A

    Interacting Protein

    SPTA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPTA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPTA1.

    SPTB;SPTBN1;ABI1;FASLG;Evl;VASP;ENAH;EVL;CBL;SHC1;BTK;UBASH3B

    Resources

    References

    • Bogardus, H; Schulz, VP; et al. Severe nondominant hereditary spherocytosis due to uniparental isodisomy at the SPTA1 locus. HAEMATOLOGICA 99:E168-E170(2014).
    • Connor, J; Dagaonkar, N; et al. AUTOSOMAL RECESSIVE HEREDITARY SPHEROCYTOSIS IN PATIENTS WITH THE C.4339-99C> T alpha LEPRA MUTATION IN THE SPTA1 GENE. PEDIATRIC BLOOD & CANCER 61:S16-S17(2014).

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