SPTA1
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Official Full Name
spectrin, alpha, erythrocytic 1 (elliptocytosis 2) -
Overview
Spectrin is a major constituent of the erythrocyte skeleton accounting for 25% of the total membrane protein and 75% of the cytoskeletal mass. Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton by associating with the cytoplasmic surface of the membrane by attachment to ankyrin. The membrane skeleton influences several cellular properties such as cell shape, restriction of mobility of the integral membrane protein exposed at the cell surface and transmembrane movement of phospholipids and cholesterol and organization of organelles. Spectrin is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. Mutations in spectrin result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. -
Synonyms
SPTA1;spectrin, alpha, erythrocytic 1 (elliptocytosis 2);spectrin alpha chain, erythrocyte;EL2;alpha-I spectrin;erythroid alpha-spectrin;HPP;HS3;SPH3;SPTA
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SPTA1-1389H | Recombinant Human SPTA1, GST-tagged | E.coli | Human | GST |
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| SPTA1-114H | Recombinant Human SPTA1 Protein, GST-tagged | E.coli | Human | GST |
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| SPTA1-4571H | Recombinant Human SPTA1 protein, His-tagged | Insect Cells | Human | His | 53-474aa |
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| SPTA1-4572H | Recombinant Human SPTA1 protein, His-tagged | Mammalian Cells | Human | His | 53-474aa |
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| SPTA1-532H | Recombinant Human SPTA1 protein(53-474aa), His&Myc-tagged | E.coli | Human | His&Myc | 53-474aa |
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Involved Pathway
SPTA1 involved in several pathways and played different roles in them. We selected most pathways SPTA1 participated on our site, such as ARMS-mediated activation,Axon guidance,Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPTA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DAP12 signaling | FRS2A,AGO1,FGFR1B,DUSP5,DUSP6,NRG3,PEA15,MOV10,NEFLB,RASGRP1 |
| DAP12 interactions | AHCYL1,SPRED2,PEA15,MARK3,THEM4,FRS2,DUSP2,NRG3,GRAP2A,CLEC5A |
| Downstream signaling of activated FGFR1 | SPRED2,PEA15,SPRED1,DUSP9,AGO2,DAB2IPB,PHB,PAQR3A,WDR83,SPNA1 |
| ARMS-mediated activation | PAQR3A,CSF2RB,RASGRP4,DAB2IPB,AKAP9,EGFR,NTF7,NRG4,NRG2A,RASGRP1 |
| Developmental Biology | KLB,MYF6,MEF2AA,MEF2B,MED6,ARPC1A,SPRED1,KCNQ2,EFNA1,FGF10B |
| Downstream signal transduction | IL17RD,SPRED3,THEM4,JAK1,SPRED2,CRKL,RASGRP4,PAQR3A,AGO3,KBTBD7 |
| Cytokine Signaling in Immune system | EDAR,NOD1,HLA-DQB2,KPNA5,HAVCR2,IFIT10,SPTB,BST2,SPNA1,USP18 |
| Axon guidance | SEMA3G,AP2A1,MET,PITPNA,FYN,SEMA7A,SCN3B,SEMA3D,ROBO3,NRG3 |
Protein Function
SPTA1 has several biochemical functions, for example, actin filament binding,calcium ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPTA1 itself. We selected most functions SPTA1 had, and list some proteins which have the same functions with SPTA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin filament binding | FLNC,CTNNA2,HIST1H2AH,MYH11A,NEBL,CAPZB,EGFR,PLS1,ACTN1,GAS7 |
| calcium ion binding | PCDH1G1,SULF1,PCDHA8,FREM1A,FREM2,NOTCH2,SLC24A4,PLSCR2,CDH10A,ANXA9 |
| structural constituent of cytoskeleton | TUBA1B,SPRR2A1,TUBB2,TUBB4B,LOR,ANK1,TUBB4A,TUBGCP2,TUBA1L,ACTR2 |
| protein binding | RAD51C,KCTD14,KIAA0368,PPARG,ARHGEF2,RWDD2B,TRIM44,PPM1F,STIM2,SEC22B |
| protein heterodimerization activity | BTBD11A,AGTR1A,SOX4,SMC3,TYRO3,KCNB1,SOS1,FLOT2,MAFG,DRD1 |
Interacting Protein
SPTA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPTA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPTA1.
SPTB;SPTBN1;ABI1;FASLG;Evl;VASP;ENAH;EVL;CBL;SHC1;BTK;UBASH3B
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References
- Bogardus, H; Schulz, VP; et al. Severe nondominant hereditary spherocytosis due to uniparental isodisomy at the SPTA1 locus. HAEMATOLOGICA 99:E168-E170(2014).
- Connor, J; Dagaonkar, N; et al. AUTOSOMAL RECESSIVE HEREDITARY SPHEROCYTOSIS IN PATIENTS WITH THE C.4339-99C> T alpha LEPRA MUTATION IN THE SPTA1 GENE. PEDIATRIC BLOOD & CANCER 61:S16-S17(2014).
