SQSTM1
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Official Full Name
sequestosome 1
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
SQSTM1 involved in several pathways and played different roles in them. We selected most pathways SQSTM1 participated on our site, such as Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SQSTM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | AKT2;CYBB;LILRB2;FCGR3;SOCS1;STAT2;CSF1;MAPK13;MAPK11 |
SQSTM1 has several biochemical functions, for example, K63-linked polyubiquitin binding, SH2 domain binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SQSTM1 itself. We selected most functions SQSTM1 had, and list some proteins which have the same functions with SQSTM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| K63-linked polyubiquitin binding | IKBKG;ZRANB1B;PRPF8;OTUD7B;TAB2;SQSTM1;ZRANB3;ZRANB1;RNF169 |
| SH2 domain binding | NUP62;NLK;PAG1;CRK;ARHGAP5;KHDRBS2;JAK2;DAG1;SRC |
| identical protein binding | UHRF1;EED;TRP63;ACPP;ETNPPL;ESYT2;CORO1B;TRADD;TP63 |
| protein binding | C10orf28;ZWINT;SRGAP2;BHLHE40;BUB3;MPP7;ZNF365;STAP1;UPF3A |
| protein homodimerization activity | ABCB9;FZD1;UBE4A;RBM11;IMPA2;SRGAP2A;TENM3;NADK2;TFAP4 |
| protein kinase C binding | GNB2L1;SQSTM1;UGT1A7;MARCKS;FEZ1;IRS1;TIRAP;HDAC7;DSP |
| protein kinase binding | PRKACA;SLC12A7;PRKAG3;CAMK2N1A;KCNQ3;FER;PRKAB1;PPP1CC;SYK |
| protein serine/threonine kinase activity | SRPK2;PRKCBA;RPS6KA3A;PDK3;STRC;NUAK1;PRKD2;MAPK14A;MAP4K5 |
| receptor tyrosine kinase binding | PTPN14;ZNF259;TP53;NRG1;GAS6;MYOC;FIZ1;SHC4;PIK3R2 |
| ubiquitin binding | CRY2;USP5;TOM1L1;KCNS1;NEDD4;RNF31;TOP2A;UBXN2B;SMAD3 |
| ubiquitin protein ligase binding | SNCAIP;PACRG;BRCA1;GABARAP;TRIB3;UBE2G1A;PCBP2;NDUFS2;LRPPRC |
| zinc ion binding | ADAMTS18;RGN;APOBEC3G;KDM2AA;RBCK1;PHEX;MMP28;MEX3B;DDX58 |
SQSTM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SQSTM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SQSTM1.
MAP1LC3B; GABARAPL2
Research Area
Related articles
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Customer Reviews (3)
Write a reviewThe band clarity of SQSTM1 in Western blot is very high, which improves the confidence of the experiment.
With this recombinant protein, the experimental time of Western blot was significantly reduced.
The short half-life and high clearance of SQSTM1 allow it to better adapt to the needs of clinical treatment, providing patients with a safer and more effective treatment option.
Q&As (6)
Ask a questionThere are currently no treatments that directly regulate SQSTM1 expression. However, its function and interacting molecules can be studied to understand its mechanism of action and discover potential treatments.
The structure of SQSTM1 determines its ability to bind to specific proteins and to regulate autophagy and signal transduction. The study of its structure can help us understand its function and mechanism of action.
SQSTM1 can interact with a variety of other proteins, including autophagy associated proteins and proteins in signal transduction pathways. These interactions enable it to regulate processes such as cell growth, differentiation, and apoptosis.
Drug development for SQSTM1 requires consideration of its specificity, safety, pharmacokinetic properties, and potential side effects. In addition, issues such as the dosage form, route of administration and design of clinical trials need to be considered.
Studies have shown that the expression level of SQSTM1 is associated with the occurrence and development of a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.
In cancer, SQSTM1 may act by promoting processes such as cell growth, migration, and invasion. It could be a potential target for cancer treatment.
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