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STUB1

  • Official Full Name

    STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

  • Overview

    STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008 [PubMed 18411298]).[supplied by OMIM, Jul 2009]
  • Synonyms

    STUB1; STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; CHIP; UBOX1; HSPABP2; NY-CO-7; SDCCAG7; E3 ubiquitin-protein ligase CHIP; antigen NY-CO-7; CLL-associated antigen KW-8; serologically defined colon cancer antigen 7; STIP1 homology and U box-containing protein 1; carboxy terminus of Hsp70-interacting protein; heat shock protein A binding protein 2 (c-terminal);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human STUB1-336H Recombinant Human STIP1 Homology And U-box Containing Protein 1 E.coli N/A
Human STUB1-30458TH Recombinant Human STUB1 E.coli N/A
Human STUB1-30459TH Recombinant Human STUB1 E.coli N/A
Human STUB1-265H Recombinant Human STUB1, His-tagged E.coli His
Human STUB1-1715HCL Recombinant Human STUB1 cell lysate N/A
Human STUB1-1597HFL Recombinant Full Length Human STUB1 Protein, C-Flag-tagged Mammalian cells Flag
Human STUB1-0446H Recombinant Human STUB1 Protein (K2-Y303), His tagged E.coli His K2-Y303
Human STUB1-2989H Recombinant Human STUB1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human STUB1-0447H Recombinant Human STUB1 Protein (K2-Y303), Tag Free E.coli No tag K2-Y303
Human STUB1-2131H-B Recombinant Human STUB1 Protein Pre-coupled Magnetic Beads HEK293
Human STUB1-2131H Recombinant Human STUB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse STUB1-16181M Recombinant Mouse STUB1 Protein Mammalian Cell His
Mouse STUB1-8834M-B Recombinant Mouse STUB1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Stub1-6203M Recombinant Mouse Stub1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse STUB1-8834M Recombinant Mouse STUB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque STUB1-4539R Recombinant Rhesus monkey STUB1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque STUB1-4355R Recombinant Rhesus Macaque STUB1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque STUB1-4355R-B Recombinant Rhesus Macaque STUB1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish STUB1-10073Z Recombinant Zebrafish STUB1 Mammalian Cell His
Chicken STUB1-3057C Recombinant Chicken STUB1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

STUB1 involved in several pathways and played different roles in them. We selected most pathways STUB1 participated on our site, such as Adaptive Immune System, Alpha-synuclein signaling, Androgen receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STUB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemRNF138;Mill2;ERAP1;WWP1;AP2B1;MAP3K8;CD300LB;CTSH;WSB1
Alpha-synuclein signalingPARK7;KLK6;TOR1A;FKBP1A;BLK;CSNK2A1;STUB1
Androgen receptor signaling pathwayTGFB1I1;RANBP9;SVILA;CDKN1A;PNRC1;RNF14;PIAS3;JUN;AES
Antigen processing: Ubiquitination &ampUBA5;UBE2L6;VPRBP;SH3RF1;LRRC41;ASB13;UFL1;TRIM41;UBR2
Proteasome degradationARIH2;RNF138;TPP2;SH3RF1;ASB3;RNF4;ASB13;TRIM41;SPSB4
Class I MHC mediated antigen processing &ampASB13;SPSB1;CTSL1;UBE2F;ERAP1;SPSB2;ATG7;SH3RF1;ASB9
presentationASB6;UBE2V1;TRIM50;DZIP3;VPRBP;KLHL20;ASB10;HECTD3;CYBB
Downregulation of TGF-beta receptor signalingSTUB1;UCHL5;SMAD3B;PMEPA1;USP15;STRAP
Immune SystemIFIT8;LY86;ABI1A;DEFB4B;ASB11;SIGLEC12;CD300C;TRIM69;NLRP4C
Parkin-Ubiquitin Proteasomal System pathwayTUBA1B;RNF19A;HSPA7;SIAH2;UBE2J2;STUB1;TUBA3D;TUBB7P;TUBA3E

STUB1 has several biochemical functions, for example, G-protein coupled receptor binding, Hsp70 protein binding, Hsp90 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STUB1 itself. We selected most functions STUB1 had, and list some proteins which have the same functions with STUB1. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor bindingAKAP5;RLN3;PYY;GNAI2B;S1PR1;QRFP;GNAL;GNAT3;GNA15
Hsp70 protein bindingMVD;CDK1;PPID;GPR37;DNAJA1;RNF207;ERN1;PARK2;PACRG
Hsp90 protein bindingUNC45A;CHORDC1;USP19;PACRG;NPAS2;UNC45B;CDC37;GBP1;PPEF2
SMAD bindingMAGI2;PRDM16;TGFBRAP1;SOD3;SMURF2;YY1;SKI;SKIL;HIPK2
TPR domain bindingHSP90AB1;RAB8B;PDE2A;STUB1;HSP90AA1
enzyme bindingDDX5;HAND2;ABCD1;NOXA1;PRKDC;HNRNPUL1;ADORA2A;TP53;PTPN1
kinase bindingTNFAIP3;PARK2;CDC37;FAS;MIDN;DGKQ;DLG4;SIT1;SP100
ligase activityRTCB;G2E3;PJA1;UBR5;RNF180;MARCH9;RNF115;NSMCE2;RNF220
misfolded protein bindingHDAC6;DNAJC3;STUB1;BAG6;EDEM1;F12;TOR1A;HSPA5;DNAJB9
protein bindingLILRA4;NUDT21;CFH;MTMR9;KLK8;SEMG2;PAF1;MEA1;ZNF695
protein binding, bridgingPPP4R2;FSCN1A;TJP2;ADAP2;TRIM5;COL1A2;CBX5;BFAR;SPRR1A
protein homodimerization activityIL6ST;NAGA;DMRTB1;PLDN;SMAD3;PTS;GIPC1;GIMAP7;MGLL
ubiquitin protein ligase activityHACE1;RBX1;FBXO30;UBE2G1B;CDC34A;MED10;BTRC;SYVN1;MARCH8
ubiquitin protein ligase activity involved in ERAD pathwaySTUB1;RNF185;SYVN1;AMFR;PARK2;TRIM25;TMEM129;RNF5
ubiquitin protein ligase bindingUBE2N;YOD1;SLC25A5;TRIM28;ACTG1;CD40;BID;RNF34;HIF1A
ubiquitin-protein transferase activityRNF182;PEX2;TRAF3;FBXO7;SIAH1A;ZNF738;RNF11;UBE2M;ANAPC4
ubiquitin-ubiquitin ligase activityUBE2K;PRPF19;UBOX5;ANAPC11;STUB1;RBX1;PPIL2;UBE4B;AMFR

STUB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STUB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of STUB1.

HSP90AA1; HSPA8; HSPA1A; UBE2N

Research Area

Related articles

Zhao, YX; Guo, H; et al. E3 Ubiquitin Ligase Cbl-b Regulates Thymic-Derived CD4(+)CD25(+) Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination. JOURNAL OF IMMUNOLOGY 194:1639-1645(2015).
Paul, I; Ghosh, MK; et al. A CHIPotle in physiology and disease. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 58:37-52(2015).
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