STUB1

  • Official Full Name

    STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

  • Overview

    STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008 [PubMed 18411298]).[supplied by OMIM, Jul 2009]

  • Synonyms

    STUB1;STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase;CHIP;UBOX1;HSPABP2;NY-CO-7;SDCCAG7;E3 ubiquitin-protein ligase CHIP;antigen NY-CO-7;CLL-associated antigen KW-8;serologically defined colon cancer antigen 7;STIP1 homology and U box-containing protein 1;carboxy terminus of Hsp70-interacting protein;heat shock protein A binding protein 2 (c-terminal)

Recombinant Proteins

  • Zebrafish
  • Mouse
  • Human
  • Chicken
  • Rhesus macaque
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • Flag
  • Avi
  • Fc
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
STUB1-10073Z Recombinant Zebrafish STUB1 Mammalian Cells Zebrafish His
STUB1-16181M Recombinant Mouse STUB1 Protein Mammalian Cells Mouse His
STUB1-265H Recombinant Human STUB1, His-tagged E.coli Human His Full L.
STUB1-30458TH Recombinant Human STUB1 E.coli Human Non
STUB1-30459TH Recombinant Human STUB1 E.coli Human Non Full L. 1-303 a.a.
STUB1-3057C Recombinant Chicken STUB1 Mammalian Cells Chicken His
STUB1-336H Recombinant Human STIP1 Homology And U-box Containing Protein 1 E.coli Human Non
STUB1-4539R Recombinant Rhesus monkey STUB1 Protein, His-tagged Mammalian Cells Rhesus macaque His
STUB1-1715HCL Recombinant Human STUB1 cell lysate Human Non
STUB1-0446H Recombinant Human STUB1 Protein (K2-Y303), His tagged E.coli Human His K2-Y303
STUB1-0447H Recombinant Human STUB1 Protein (K2-Y303), Tag Free E.coli Human Non K2-Y303
STUB1-1597HFL Recombinant Full Length Human STUB1 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
STUB1-2131H Recombinant Human STUB1 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
STUB1-2131H-B Recombinant Human STUB1 Protein Pre-coupled Magnetic Beads HEK293 Human
STUB1-2989H Recombinant Human STUB1 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
STUB1-4355R Recombinant Rhesus Macaque STUB1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
STUB1-4355R-B Recombinant Rhesus Macaque STUB1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Stub1-6203M Recombinant Mouse Stub1 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
STUB1-8834M Recombinant Mouse STUB1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
STUB1-8834M-B Recombinant Mouse STUB1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    STUB1 involved in several pathways and played different roles in them. We selected most pathways STUB1 participated on our site, such as Adaptive Immune System,Alpha-synuclein signaling,Androgen receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STUB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System TREML4,CD200R1,KIF3C,SEC23A,PJA2,LILRB5,ASB6,ASB11,NA,ASB4
    Proteasome degradation CMTM2A,WSB1,ASB3,PJA1,ASB10,SPSB4,ASB4,DTX3L,DZIP3,TRIM11
    Immune System IFIT14,CD200R4,NPEPPS,MGC174155,WWP1,Mill2,CLEC2D,DDX41,KIF5A,AP1G1
    Class I MHC mediated antigen processing &amp TRAF7,RNF4,SEC61B,RNF25,RNF19B,PJA1,ASB10,ASB7,SH3RF1,ASB8
    Downregulation of TGF-beta receptor signaling USP15,SMAD3B,PMEPA1,UCHL5,STRAP
    Androgen receptor signaling pathway CTNNB2,SMARCE1,TGFB1I1,DAXX,PNRC1,CCDC102A,CARM1,SMAD3B,SVILA,ETV5A
    Alpha-synuclein signaling FKBP1A,CSNK2A1,KLK6,PARK7,BLK,TOR1A
    Parkin-Ubiquitin Proteasomal System pathway TUBA3E,TUBA3D,HSPA7,TUBA1B,SIAH2,TUBB7P,HSPA14,RNF19A,UBE2J2
    Antigen processing: Ubiquitination &amp UBA5,ASB9,UBE2V1,CMTM2A,KLHL20,ARIH2,UFL1,RNF41,DTX3L,KLHL21

    Protein Function

    STUB1 has several biochemical functions, for example, G-protein coupled receptor binding,Hsp70 protein binding,Hsp90 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STUB1 itself. We selected most functions STUB1 had, and list some proteins which have the same functions with STUB1. You can find most of the proteins on our site.

    Function Related Protein
    Hsp70 protein binding ST13,CDKN1B,PPEF2,C11orf73,DNAJB1,DNAJA1,DNAJC10,L7RN6,BAG6,GPR37
    ubiquitin-protein transferase activity FBXO30B,TRIM24,RNF146,RNF213,UBR1,TSPAN17,CNOT4B,ANKIB1,PJA2,HERC2
    protein binding EIF2B1,KIAA1274,NOTCH4,PPP1R15B,PIM3,GLYAT,NAA30,LILRB3,CDK7,SMN2
    ubiquitin protein ligase activity involved in ERAD pathway AMFR,PARK2,TRIM25,SYVN1,RNF185,RNF5,TMEM129
    ubiquitin protein ligase activity ANKIB1,C18orf25,UBE2Z,WWP2,RNF25,RNF7,RNF121,FBXL22,UBE2N,CBLC
    protein homodimerization activity NR6A1A,TYW5,TIMM10,HMOX1,CHMP4A,TMEM173,USH1G,GNPTG,MZF1,APOC2
    kinase binding PER1,DLG4,SGOL1,TENC1,ABI2,JAKMIP2,TAX1BP1,CTNNB1,SNAI1,DLG3
    Hsp90 protein binding NPAS2,HIF1A,FKBP6,ARNTL,ERN1,PACRG,TELO2,EIF2AK3,UNC45B,UNC45A
    ubiquitin-ubiquitin ligase activity PRPF19,PPIL2,RBX1,UBOX5,ANAPC11,UBE4B,AMFR,UBE2K

    Interacting Protein

    STUB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STUB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of STUB1.

    HSP90AA1;HSPA8;HSPA1A;UBE2N

    Resources

    Research Area

    Adaptor Proteins
    Ubiquitin-related Molecules in the Akt Pathway
    E3 Ubiquitin Ligases

    References

    • Zhao, YX; Guo, H; et al. E3 Ubiquitin Ligase Cbl-b Regulates Thymic-Derived CD4(+)CD25(+) Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination. JOURNAL OF IMMUNOLOGY 194:1639-1645(2015).
    • Paul, I; Ghosh, MK; et al. A CHIPotle in physiology and disease. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 58:37-52(2015).

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All STUB1 Products

    Required fields are marked with *

    My Review for All STUB1 Products

    Required fields are marked with *