STUB1
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Official Full Name
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -
Overview
STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008 [PubMed 18411298]).[supplied by OMIM, Jul 2009] -
Synonyms
STUB1;STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase;CHIP;UBOX1;HSPABP2;NY-CO-7;SDCCAG7;E3 ubiquitin-protein ligase CHIP;antigen NY-CO-7;CLL-associated antigen KW-8;serologically defined colon cancer antigen 7;STIP1 homology and U box-containing protein 1;carboxy terminus of Hsp70-interacting protein;heat shock protein A binding protein 2 (c-terminal)
Recombinant Proteins
- Zebrafish
- Mouse
- Human
- Chicken
- Rhesus macaque
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- Flag
- Avi
- Fc
- DDK
- Myc
Involved Pathway
STUB1 involved in several pathways and played different roles in them. We selected most pathways STUB1 participated on our site, such as Adaptive Immune System,Alpha-synuclein signaling,Androgen receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STUB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | KLRF1,SIGLEC11,CTSL1,CTSB,KIF22,MICA,HCST,LILRB3,DYNC1H1,ASB6 |
| Downregulation of TGF-beta receptor signaling | SMAD3B,UCHL5,PMEPA1,USP15,STRAP |
| Parkin-Ubiquitin Proteasomal System pathway | TUBA3D,TUBA3E,HSPA7,HSPA14,UBE2J2,TUBA1B,TUBB7P,SIAH2,RNF19A |
| Immune System | TAX1BP1,IFIT8,SRMS,DEFB103A,KIF26A,ERAP2,DYNC1I1,CFHL4,CLEC2H,KLRB1F |
| Alpha-synuclein signaling | CSNK2A1,PARK7,FKBP1A,KLK6,BLK,TOR1A |
| Class I MHC mediated antigen processing & | TRIM39,UBE2V1,SPSB2,KLHL21,PJA2,RNF182,ASB13,ERAP2,FCGR1B,VPRBP |
| Proteasome degradation | RBCK1,ASB7,ASB11,WWP1,TRIM50,RNF138,LRSAM1,IWS1,FBXO17,HECTD3 |
| presentation | RNF123,UFL1,RNF138,ERAP2,SPSB2,SEC23A,ATG7,TPP2,ASB13,UBE2E3 |
| Antigen processing: Ubiquitination & | TRIM63,TRIM39,UBR2,RNF220,RNF138,SPSB2,UBE2U,ASB14,SPSB1,UBR1 |
Protein Function
STUB1 has several biochemical functions, for example, G-protein coupled receptor binding,Hsp70 protein binding,Hsp90 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STUB1 itself. We selected most functions STUB1 had, and list some proteins which have the same functions with STUB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | FBXO3,RNF6,SIAH2L,TRIM5,TRAF4A,CMTM2A,UBE2A,UBR1,FEM1A,NEDD4L |
| TPR domain binding | RAB8B,HSP90AA1,HSP90AB1,PDE2A |
| ubiquitin protein ligase binding | RB1,ARRB1,USP13,BID,TRIB1,TNFRSF14,OTUB1,USP2,TRAF5,GPI1 |
| enzyme binding | CYP2A4,EIF2AK3,AKIRIN2,MDM4,TAL1,ARRB2,RPS3,RPS2,HIST1H2AI,LAMB1 |
| Hsp70 protein binding | METTL21A,DNAJA1,CDKN1B,FAM119A,STIP1,RPS3,PACRG,BAG6,PPID,CDK1 |
| SMAD binding | ACVR1,TGFBRAP1,USP15,SKOR2,BMPR1B,CREBBP,PURB,CTNNB1,BMP2,SMURF2 |
| ubiquitin protein ligase activity involved in ERAD pathway | PARK2,TRIM25,SYVN1,AMFR,TMEM129,RNF5,RNF185 |
| protein binding, bridging | FLRT2,CNKSR1,BFAR,FRMD4A,LOR,TCAP,NEFH,MMS19,STX1A,FSCN2 |
| ligase activity | UBE2D1B,C12orf51,PJA2,MARCH5,RNF25,SHRPRBCK1R,UBE2NA,TTLL6,TRIM17,RNF152 |
Interacting Protein
STUB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STUB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of STUB1.
HSP90AA1;HSPA8;HSPA1A;UBE2N
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References
- Zhao, YX; Guo, H; et al. E3 Ubiquitin Ligase Cbl-b Regulates Thymic-Derived CD4(+)CD25(+) Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination. JOURNAL OF IMMUNOLOGY 194:1639-1645(2015).
- Paul, I; Ghosh, MK; et al. A CHIPotle in physiology and disease. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 58:37-52(2015).
