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SYT6

  • Official Full Name

    synaptotagmin VI

  • Overview

    Synaptotagmin-6 is a protein that in humans is encoded by the SYT6 gene.Synaptotagmins, such as SYT6, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.
  • Synonyms

    SYT6; synaptotagmin VI; synaptotagmin-6; sytVI;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • C
  • Myc
  • DDK
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SYT6-3087H Recombinant Human SYT6, His-tagged E.coli His C-term-348aa
Human SYT6-398H Recombinant Human SYT6, His-tagged E.coli His Val359-Leu510
Human SYT6-647HCL Recombinant Human SYT6 lysate HEK293 N/A
Human SYT6-329H Recombinant Human SYT6 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human SYT6-3051H Recombinant Human SYT6 protein, His-tagged E.coli His 202-424 aa
Human SYT6-3093H Recombinant Human SYT6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse SYT6-16338M Recombinant Mouse SYT6 Protein Mammalian Cell His
Mouse Syt6-6263M Recombinant Mouse Syt6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SYT6-8930M Recombinant Mouse SYT6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SYT6-8930M-B Recombinant Mouse SYT6 Protein Pre-coupled Magnetic Beads HEK293
Rat SYT6-5884R Recombinant Rat SYT6 Protein Mammalian Cell His
Rat SYT6-5543R-B Recombinant Rat SYT6 Protein Pre-coupled Magnetic Beads HEK293
Rat SYT6-5543R Recombinant Rat SYT6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SYT6 Related Articles

SYT6 involved in several pathways and played different roles in them. We selected most pathways SYT6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SYT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

SYT6 has several biochemical functions, for example, calcium ion binding, NOT calcium-dependent phospholipid binding, clathrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SYT6 itself. We selected most functions SYT6 had, and list some proteins which have the same functions with SYT6. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingATP2A1;PCDH2G4;BMP1B;NOL3;FKBP7;LDLRB;CLSTN3;HPCAL1;SLC25A24L
NOT calcium-dependent phospholipid bindingSYT4;SYT11B;MCTP1;SYT14;SYT6;SYT13;MCTP2;SYT16
clathrin bindingSYT9B;DOC2D;SYT4;CLINT1;PICALMB;RPH3A;HIP1R;SYT13;TOM1
protein bindingC4BPA;PPP2R5E;C16orf70;ST13;DYM;VEGFAA;NINJ1;OSBPL2;UBA52
protein homodimerization activityPSMD7;DNM1L;CTBP1;UNC13A;DMRTB1;TSC2;TGFB1;SOD1;RAB11FIP4
syntaxin bindingCPLX3;SYT17;SYT5B;VPS54;SYT15;STX10;SYT3;SYT10;SYT16

SYT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYT6.

Rodriguez, F; Zanetti, MN; et al. Munc18-1 Controls SNARE Protein Complex Assembly during Human Sperm Acrosomal Exocytosis. JOURNAL OF BIOLOGICAL CHEMISTRY 287:43825-43839(2012).
Bennett, JC; Roggero, CM; et al. Calcineurin-mediated Dephosphorylation of Synaptotagmin VI Is Necessary for Acrosomal Exocytosis. JOURNAL OF BIOLOGICAL CHEMISTRY 285:26269-26278(2010).
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