SYVN1

  • Official Full Name

    synovial apoptosis inhibitor 1, synoviolin
  • Overview

    This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms.
  • Synonyms

    SYVN1;synovial apoptosis inhibitor 1, synoviolin;E3 ubiquitin-protein ligase synoviolin;HRD1;KIAA1810;MGC40372

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • Rhesus macaque
  • zebrafish
  • Mus musculus
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • SUMO
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
SYVN1-109H Active Recombinant Human SYVN1, His & SUMO-tagged E.coli Human His&SUMO 236-617 a.a.
SYVN1-12007Z Recombinant Zebrafish SYVN1 Mammalian Cells Zebrafish His
SYVN1-16347M Recombinant Mouse SYVN1 Protein Mammalian Cells Mouse His
SYVN1-4592R Recombinant Rhesus monkey SYVN1 Protein, His-tagged Mammalian Cells Rhesus macaque His
SYVN1-1295HCL Recombinant Human SYVN1 293 Cell Lysate HEK293 Human Non
SYVN1-1296HCL Recombinant Human SYVN1 293 Cell Lysate HEK293 Human Non
RFL18455DF Recombinant Full Length Danio Rerio E3 Ubiquitin-Protein Ligase Synoviolin(Syvn1) Protein, His-Tagged E.coli zebrafish His Full L. Full Length (21-625)
RFL18989HF Recombinant Full Length Human E3 Ubiquitin-Protein Ligase Synoviolin(Syvn1) Protein, His-Tagged E.coli Human His Full L. Full Length of Mature Protein (23-617)
RFL32310MF Recombinant Full Length Mouse E3 Ubiquitin-Protein Ligase Synoviolin(Syvn1) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length of Mature Protein (23-612)
SYVN1-4408R Recombinant Rhesus Macaque SYVN1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
SYVN1-4408R-B Recombinant Rhesus Macaque SYVN1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
SYVN1-5477H Recombinant Human SYVN1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
SYVN1-8935M Recombinant Mouse SYVN1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
SYVN1-8935M-B Recombinant Mouse SYVN1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    SYVN1 involved in several pathways and played different roles in them. We selected most pathways SYVN1 participated on our site, such as Ubiquitin mediated proteolysis,Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYVN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis BTRC,TRIM37,UBE2QL1,SOCS1,RCHY1,CDC16,FZR1,UBE3A,UBE2M,PRP19
    Protein processing in endoplasmic reticulum LMAN2,HYOU1,HERPUD1,DNAJC5GA,MAPK8A,HSPA8,CAPN1A,EDEM2,UBE2G1A,RNF185

    Protein Function

    SYVN1 has several biochemical functions, for example, ATPase binding,chaperone binding,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SYVN1 itself. We selected most functions SYVN1 had, and list some proteins which have the same functions with SYVN1. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity RNF115,ATG10,TRIM68,RNF139,FPGS,MYLIP,TRIM39,KCMF1,BARD1,RTCB
    ubiquitin protein ligase activity SIAH1A,RNF41,ANKIB1A,RAG1,RNF217,RNF165,NEDD4L,TOPORS,RNF2,MED27
    protein binding TAF6,UBE2D2A,NRP1B,GATA2,KLHDC4,KCTD9,FOXH1,SMAD5,PTGDS,NATD1
    zinc ion binding RGN,RBM14A,MKRN2,USP22,TAF15,TRIM11,USP49,DPYS,KAT7B,TRIM35-24
    ubiquitin protein ligase activity involved in ERAD pathway PARK2,TRIM25,AMFR,RNF5,RNF185,TMEM129,STUB1
    chaperone binding BAG1,CXorf41,GNB5,CDC37,DNAJA4,TP53,GET4,BAG3,ATP1A1,AHSA1L
    unfolded protein binding HSPE1,CRYAA,CALR3,CANX,AFG3L2,CLGN,UGGT1,CCT7,PPIA,ERLEC1
    ubiquitin-specific protease binding VPS24,CHMP3,VCP,BAG6,MARCH6,PARK7,RAD23A,SELS,PARK2,AMFR
    ATPase binding PIH1D1,SNX10,ATP6V0A1B,DNAJC10,FXYD3,ATP6V1G1,SVIP,FAM119A,ABCA1,ANK1

    Interacting Protein

    SYVN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYVN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYVN1.

    TP53;ERN1;VCP;UBXN6;ATN1;q5ne83_fratt;gltX;ftsZ;UBE2U;frwC;ezrA;q81wx2_bacan;q8cki1_yerpe;kefB

    Resources

    References

    • Hara, T; Hashimoto, Y; et al. Rer1 and calnexin regulate endoplasmic reticulum retention of a peripheral myelin protein 22 mutant that causes type 1A Charcot-Marie-Tooth disease. SCIENTIFIC REPORTS 4:-(2014).
    • Crider, A; Pandya, CD; et al. Ubiquitin-proteasome dependent degradation of GABA(A)alpha 1 in autism spectrum disorder. MOLECULAR AUTISM 5:-(2014).

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