SYVN1
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Official Full Name
synovial apoptosis inhibitor 1, synoviolin -
Overview
This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. -
Synonyms
SYVN1;synovial apoptosis inhibitor 1, synoviolin;E3 ubiquitin-protein ligase synoviolin;HRD1;KIAA1810;MGC40372
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- zebrafish
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- His
- SUMO
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
SYVN1 involved in several pathways and played different roles in them. We selected most pathways SYVN1 participated on our site, such as Ubiquitin mediated proteolysis,Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYVN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | MGRN1B,COP1,UBE2NB,UBE2D1A,TCEB2,RFWD2,TRIP12,UBE2Q1,SOCS3B,KEAP1 |
| Protein processing in endoplasmic reticulum | SEC62,UBE2J2,UBE2E1,ERN1,SEC13,MBTPS2,TUSC3,SAR1A,HSP70L,VCP |
Protein Function
SYVN1 has several biochemical functions, for example, ATPase binding,chaperone binding,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SYVN1 itself. We selected most functions SYVN1 had, and list some proteins which have the same functions with SYVN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase activity involved in ERAD pathway | TMEM129,TRIM25,AMFR,PARK2,STUB1,RNF185,RNF5 |
| protein binding | ARF1,CRNKL1,YES1,PLAUR,SH2B2,CEP76,BCAR3,TRAPPC2L,SH2B3,PRR3 |
| ligase activity | CBX4,SH3RF1,TRIM24,PARK2,TRIM37,PIAS1,RNF182,RNF19A,RANBP2,DTX3L |
| ubiquitin-specific protease binding | SELS,CHMP3,MARCH6,BAG6,VPS24,RAD23A,VCP,AMFR,SART3,PARK7 |
| ubiquitin protein ligase activity | HUWE1,HERC3,UBE2V1,HERC4,RNF19B,UBE3B,MED27,BRAP,UBE2J2,UBE2NB |
| ATPase binding | CAV1,PIH1D1,ATP6V1G3,PTPN3,Ar,ATPIF1,ABCA1,ATP6V0A1,SDF2L1,FXYD3 |
| chaperone binding | TBCE,BAG1,SDF2L1,DNAJA3A,DNAJC3,UBL4A,HLA-B,HES1,VWF,HSPA5 |
| zinc ion binding | PRKCB,APOBEC3D,RNF11,HRG,CAR5A,NR1H4,LIMS3L,KDM5BA,CSRP1A,ZSWIM1 |
| unfolded protein binding | HSPA1A,RUVBL2,AIPL1,HSP90B1,HSPA6,CALR3,PFDN4,CRYABA,PPIA,DNAJA3 |
Interacting Protein
SYVN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYVN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYVN1.
TP53;ERN1;VCP;UBXN6;ATN1;q5ne83_fratt;gltX;ftsZ;UBE2U;frwC;ezrA;q81wx2_bacan;q8cki1_yerpe;kefB
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References
- Hara, T; Hashimoto, Y; et al. Rer1 and calnexin regulate endoplasmic reticulum retention of a peripheral myelin protein 22 mutant that causes type 1A Charcot-Marie-Tooth disease. SCIENTIFIC REPORTS 4:-(2014).
- Crider, A; Pandya, CD; et al. Ubiquitin-proteasome dependent degradation of GABA(A)alpha 1 in autism spectrum disorder. MOLECULAR AUTISM 5:-(2014).
