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ADAM17

  • Official Full Name

    ADAM metallopeptidase domain 17

  • Overview

    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]
  • Synonyms

    ADAM17; ADAM metallopeptidase domain 17; CSVP; TACE; NISBD; ADAM18; CD156B; disintegrin and metalloproteinase domain-containing protein 17; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; ADAM metallopeptidase domain 18; tumor necrosis factor, alpha, converting enzyme;

  • Recombinant Proteins
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Assay Kits
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADAM17-593H Active Recombinant Human ADAM17 Insect Cell N/A 215 to 651
Human ADAM17-7114H Recombinant Human ADAM17 protein, His-tagged E.coli His Lys226~Arg473 (Accession # P78536)
Human ADAM17-278H Recombinant Human ADAM17 Protein, GST-tagged Wheat Germ GST
Human ADAM17-592H Recombinant Human ADAM Metallopeptidase Domain 17, His-tagged Insect Cell His
Human ADAM17-26135TH Recombinant Human ADAM17 Wheat Germ N/A 100 amino acids
Human ADAM17-5123H Recombinant Human ADAM17 Protein (Met1-Asp563), C-His tagged Mammalian cells C-His Met1-Asp563
Mouse Adam17-522M Recombinant Mouse Adam17 protein, His-tagged HEK293 His Pro 18 - Asp 563
Mouse Adam17-256M Recombinant Mouse Adam17 protein, His-tagged HEK293 His 546
Mouse Adam17-308M-B Recombinant Mouse Adam17 Protein Pre-coupled Magnetic Beads HEK293
Mouse Adam17-308M Recombinant Mouse Adam17 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ADAM17-085M Recombinant Mouse ADAM17 Protein, His-tagged HEK293 His 827
Rat Adam17-8788R Active Recombinant Rat Adam17 protein(Met1-Asp563), His-tagged HEK293 C-His Met1-Asp563
Rat Adam17-7115R Recombinant Rat Adam17 protein, His & T7-tagged E.coli His/T7 Leu221~Ser451 (Accession# Q9Z1K9)
Rat ADAM17-501R Recombinant Rat ADAM17 Protein Mammalian Cell His
Rat ADAM17-1198RCL Recombinant Rat ADAM17 cell lysate Human Cell N/A
Rat ADAM17-073R Recombinant Rat ADAM17 Protein, His-tagged HEK293 His 827
Rat ADAM17-157R Recombinant Rat ADAM17 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ADAM17-157R-B Recombinant Rat ADAM17 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL-25931HF Recombinant Full Length Human Disintegrin And Metalloproteinase Domain-Containing Protein 17(Adam17) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (215-824)
Chicken ADAM17-1867C Recombinant Chicken ADAM17 Mammalian Cell His
Kit-0049 ADAM17 Inhibitor Screening Assay Kit N/A
Kit-0048 ADAM17 fluorometric drug discovery Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADAM17 Related Articles
  • ADAM17 Related Research Area
  • ADAM17 Related Signal Pathway

ADAM17 involved in several pathways and played different roles in them. We selected most pathways ADAM17 participated on our site, such as Notch signaling pathway, Alzheimers disease, Epithelial cell signaling in Helicobacter pylori infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Notch signaling pathwayCNTN6;NOTCH2;MARK2;DTX3L;CTBP1;PSENEN;DVL1B;ADAM17A;KAT2A
Alzheimers diseaseCALM1;COX4I1;FADD;NDUFA13;NDUFB6;NDUFB7;COX7A2L;Casp3;NDUFS6
Epithelial cell signaling in Helicobacter pylori infectionATP6V1B1;CDC42;ATP6V0C;ATP6V0A1;ATP6V1H;GIT1;ATP6V1F;LYN;ATP6V1D

ADAM17 has several biochemical functions, for example, Notch binding, PDZ domain binding, SH3 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM17 itself. We selected most functions ADAM17 had, and list some proteins which have the same functions with ADAM17. You can find most of the proteins on our site.

Function Related Protein
Notch bindingNOTCH1;GALNT11;CHAC1;ADAM17;DLL3;AAK1;NOV;DLL4;DLL1
PDZ domain bindingATP2B1B;LRP2;ATP2B2;GJA1;DLG1;FZD8;SLC22A5;TGFBR3;ERC1
SH3 domain bindingEVL;PLSCR3;FMNL3;PARK2;USP8;NCKIPSD;INPPL1;ADAM19;SH3BP5B
integrin bindingITGB5;ACTN3;FBN1;CTGF;L1CAM;CD151;FCER2;Tcam1;ITGA3
interleukin-6 receptor bindingERAP1;IL6;CNTF;PYCARD;ADAM17
metalloendopeptidase activityNLN;NPSN;ADAMTS12;C6AST4;UQCRC2B;MMP20;MMEL1;ADAM8A;YBEY
metallopeptidase activityCLCA5;STAMBPL1;Adamts19;ANPEP;MMP14B;BMP1;ADAMTS5;ANPEPA;ADAMTS7
protein bindingMTAP1B;PTH1R;SP1;ZFP143;ATG101;FMO4;PUF60;GRM1;CXCR4
zinc ion bindingDBF4;LRSAM1;UBR5;PIAS4B;IDE;ZNF185;TP53I3;TRIM3B;MUL1B

ADAM17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM17 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM17.

DLG1; MAD2L1; APP; ITGB1; PDIA3; JAG1; TGFA; PTPN3; thiF; Sgol2

Li, GR; Forest, F; et al. A novel marker ADAM 17 for clear cell renal cell carcinomas: Implication for patients' prognosis. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 32:1272-1276(2014).
Arenaccio, C; Chiozzini, C; et al. Exosomes from Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Cells License Quiescent CD4(+) T Lymphocytes To Replicate HIV-1 through a Nef- and ADAM17-Dependent Mechanism. JOURNAL OF VIROLOGY 88:11529-11539(2014).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
Is ADAM17 protein involved in the renin-angiotensin system? 08/01/2022

ADAM17 is a negative regulator of the RAS system.

My research requires high protein purity, can I customize > 90% ADAM17 protein? 06/05/2022

Yes, we have produced ADAM17 protein of this purity.

What proteins does ADAM17 cleave? 04/07/2022

ADAM17 protein can cleave IL6R, TNFR1, ACE2, etc.

Where ADAM17 is highly expressed? 06/25/2021

ADAM17 is widely expressed in somatic and immune cells

In addition to Diabetes mellitus and cardiomyopathy-related research, ADAM17 is currently used in the research of which diseases? 01/21/2021

ADAM17 is also currently being used in studies of breast cancer and gastric cancer, etc.

Is ADAM17 associated with the EGFR-PI3K-AKT pathway? 10/03/2020

ADAM17 is an activator that mediates the EGFR-PI3K-AKT pathway.

Does the package insert for ADAM17 contain detailed information on the handling of the lyophilized powder product? 04/19/2020

The product manual will contain relevant content on product handling, and you can also consult our technical experts on related issues.

ADAM17 protein is also involved in recent activities? 12/11/2019

Yes, ADAM17 protein is involved in this promotion.

Does ADAM17 mediate the Notch pathway? 10/05/2019

ADAM17 acts as an activator of Notch pathway by mediating the of cleavage of Notch.

Does adding His tag have any effect on protein? 04/24/2019

Addition of His tags usually does not affect the function, properties of the target protein.

Customer Reviews (3)

Write a review
Reviews
04/08/2022

    Cheap price, high quality products, worth buying again

    03/15/2019

      The high quality of the purchased protein helped me to obtain satisfactory experimental results.

      02/26/2019

        Good after-sales service attitude, helped me solve a lot of problems in the experiment.

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