"TACE" Related Products

        TACE Inhibitor Screening Kit

        Cat.No. : Kit-0810
        Product Overview : In TACE inhibitor screening Kit, TACE (tumor necrosis factor-α-converting enzyme) hydrolyzes the specific FRET substrate to release the quenched fluorescent group, which can be detected fluorometrically at Ex/Em318/449 nm. In the presence of the potent TACE inhibitor, the hydrolyzation of substrate will be impeded. The kit provides a rapid, simple, sensitive and reliable test suitable for high-throughput screening of TACE inhibitors and can be modified to check the relative TACE activity. Inhibitor Control GM6001 is included to compare the efficacy of test inhibitors.
        Size : 100 tests
        Description : The TACE (tumor necrosis factor-α-converting enzyme), also called ADAM metallopeptidase domain 17 (ADAM17), is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases. TACE is believed to be involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. This process, which is also known as shedding, involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-α), and is of known physiological importance.
        Applications : Functional Studies more details
        Storage : Store at -20°C.
        Kit Components : Components: Identifier; TACE Assay Buffer: WM; TACE Enzyme: Green; TACE Inhibitor Control: Purple; TACE Substrate: Red
        Assay time : 0h 20m
        Products Types

        ◆ Assay kits

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