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TAF12

Official Full Name

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
Overview

Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene.
Synonyms

TAF12; TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa; TAF2J, TATA box binding protein (TBP) associated factor, RNA polymerase II, J, 20kD; transcription initiation factor TFIID subunit 12; TAFII20; TAF15; TAF2J; TAFII 20/TAFII 15; TAFII20/TAFII15; Transcription initiation factor TFIID 20/15 kDa subunits; TAFII-20/TAFII-15; OTTHUMP00000003785; OTTHUMP00000003786; TATA box binding protein (TBP)-associated factor, RNA polymerase II, J, 20kD;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

GST
His
SUMO
Myc
DDK
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TAF12-3101H	Recombinant Human TAF12, GST-tagged	E.coli	GST	1-161aa	$319 / 25μg
Human	TAF12-101H	Recombinant Human TAF12 Protein, His-tagged	E.coli	His		Inquiry
Human	TAF12-1276HCL	Recombinant Human TAF12 293 Cell Lysate	HEK293	Non		Inquiry
Human	TAF12-2460H	Recombinant Human TAF12 protein, His-tagged	E.coli	His	1-161 aa	$319 / 25μg
Human	TAF12-6392H	Recombinant Human TAF12 Protein (Met1-Lys161), N-His tagged	E.coli	His	Met1-Lys161	Inquiry
Human	TAF12-265H	Recombinant Human TAF12 Protein, MYC/DDK-tagged, C13 and N15-labeled	HEK293	Myc&DDK		Inquiry
Human	TAF12-4448H	Recombinant Human TAF12 protein, His-SUMO-tagged	E.coli	His&SUMO	1-161aa	Inquiry
Mouse	Taf12-6276M	Recombinant Mouse Taf12 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Zebrafish	TAF12-9827Z	Recombinant Zebrafish TAF12	Mammalian Cell	His		Inquiry
Chicken	TAF12-2583C	Recombinant Chicken TAF12	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

TAF12 involved in several pathways and played different roles in them. We selected most pathways TAF12 participated on our site, such as Basal transcription factors, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAF12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Basal transcription factors	TAF6L;TAF7;TAF3;TAF15;TAF5;GTF2H1;TAF6;TAF2;GTF2E1

TAF12 has several biochemical functions, for example, DNA binding, contributes_to histone acetyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAF12 itself. We selected most functions TAF12 had, and list some proteins which have the same functions with TAF12. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	HOXC9A;NR1H2;SETDB1;ZFP410;PATZ1;DEAF1;ZNF146;TRERF1;HER8A
contributes_to histone acetyltransferase activity	TADA3;ELP4;ING3;KAT2A;SAP130;TADA1;TAF6L;TAF12;TAF10
protein binding	PEX12;TMEM25;BNIP3;NR2F2;EIF5A;TREX1;NEK1;SH2D1B;RBBP6
protein heterodimerization activity	POLA1;BTBD11A;SNX5;PIK3R2;CAPN2;TYRP1;MYOD1;HER11;ZBTB1
transcription coactivator activity	MED7;JUNB;NEUROG3;SUB1A;BCL10;PSMD9;WNT3A;GABPA;PER2
contributes_to transcription factor activity, sequence-specific DNA binding	TAF7;FOXH1;NKX2;VDRB;VDRA;SMAD4;NKX2-5;MAFGB;VDR
transcription factor binding	SMARCA4;HYAL1;SP100;TRAPPC2;LCOR;ARNT;BPTF;PARK7;HES4

TAF12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAF12 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAF12.

TBP; PRKAR2B; TAF1C; TAF4; Pcdh1; h3_peptide_2-18; ZWINT; Cdk1; RAB5A; TAF10; SNW1; KIF22; Dclre1b; Poc1a; Lin28a; Cbx7

Research Area

Baldwin, KM; Ehrenberg, PK; et al. HLA class II diversity in HIV-1 uninfected individuals from the placebo arm of the RV144 Thai vaccine efficacy trial. TISSUE ANTIGENS 85:117-126(2015).

Roh, EY; In, JW; et al. Performance of LIFECODES HLA-DQB1 Typing Kit Using Luminex Platform in Koreans. ANNALS OF LABORATORY MEDICINE 35:123-127(2015).