• Official Full Name

    T-cell acute lymphocytic leukemia 1

  • Overview

    T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene.
  • Synonyms

    TAL1; T-cell acute lymphocytic leukemia 1; TCL5; T-cell acute lymphocytic leukemia protein 1; bHLHa17; SCL; Class A basic helix-loop-helix protein 17; OTTHUMP00000009563; OTTHUMP00000009564; Stem cell protein; T cell acute lymphocytic leukemia 1; T cell acute lymphocytic leukemia 1 protein; T cell leukemia/lymphoma 5 protein; T-cell leukemia/lymphoma protein 5; Tal 1; Tal 1 product; TAL 1 protein; TAL-1; TAL1_HUMAN; TCL 5; tal-1 product;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TAL1-1259HCL Recombinant Human TAL1 293 Cell Lysate HEK293 N/A
Human TAL1-2749H Recombinant Human TAL1 Protein, His-tagged E.coli N-His Pro29-Arg331
Zebrafish TAL1-12439Z Recombinant Zebrafish TAL1 Mammalian Cell His
Chicken TAL1-6904C Recombinant Chicken TAL1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TAL1 Related Articles
  • TAL1 Related Research Area

TAL1 involved in several pathways and played different roles in them. We selected most pathways TAL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TAL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

TAL1 has several biochemical functions, for example, E-box binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAL1 itself. We selected most functions TAL1 had, and list some proteins which have the same functions with TAL1. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter sequence-specific DNA bindingZFP335;EGR1;NR4A2;RUVBL2;NLRC5;H3F3A;SOX11;TBR1;SMAD5
RNA polymerase II distal enhancer sequence-specific DNA bindingSIX3;NR5A1;T;PROP1;SFPI1;NONO;HOXB5;RUVBL2;SOX10
RNA polymerase II regulatory region sequence-specific DNA bindingBARHL1B;ZNF79;LMO2;ZMYND11;ARHGAP35;PKNOX2;MYOD1;PLAGL1;KAT2B
RNA polymerase II transcription factor activity, sequence-specific DNA bindingZSCAN18;EPAS1;FOXG1B;HOXA13B;PLAG1;RUNX2B;CC2D1A;HOXA13A;ETS1
RNA polymerase II transcription factor bindingTOX2;GATA2;GSK3B;ZGLP1;HCLS1;DHX9;GFI1B;TEAD3;Ar
chromatin bindingMED12;NR5A1A;CITED2;POU5F3;GATA5;SIRT2;POLR3D;NAP1L2;TCF7L1A
histone deacetylase bindingNR2E1;ANKRD1;YWHAE;CBX5;KPNA2;RAD9A;BRMS1L;TAL1;NKX3
protein bindingTBL3;COMMD9;PFKL;C8orf48;UBE2V2;PIBF1;SCRT1;ZBTB48;SUV39H1
protein heterodimerization activityZBTB1;BTBD11A;ANO9A;UGT1A9;ADD2;NR4A1;SMAD3;JAM2;SCGB2A1
transcription factor activity, sequence-specific DNA bindingMYC;FOXO1A;VED;CSRNP3;JUNBB;TCEAL1;SLC2A4RG;ZNF234;RARGA
transcription regulatory region DNA bindingSMARCA2;SOX2;ZBTB14;PPARG;KLF15;RFX3;PROX1;ZFP746;JUN

TAL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAL1.

TCF3; TCF12; Lmo2; ETS1; RUNX1; CDK9; TRIM33

Karrman, K; Kjeldsen, E; et al. The t(X;7)(q22;q34) in paediatric T-cell acute lymphoblastic leukaemia results in overexpression of the insulin receptor substrate 4 gene through illegitimate recombination with the T-cell receptor beta locus. BRITISH JOURNAL OF HAEMATOLOGY 144:546-551(2009).
Biggs, JS; Wan, J; et al. Transcription factor binding to a putative double e-box motif represses CYP3A4 expression in human lung cells. MOLECULAR PHARMACOLOGY 72:514-525(2007).
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