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TAL1

Official Full Name

T-cell acute lymphocytic leukemia 1
Overview

T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene.
Synonyms

TAL1; T-cell acute lymphocytic leukemia 1; TCL5; T-cell acute lymphocytic leukemia protein 1; bHLHa17; SCL; Class A basic helix-loop-helix protein 17; OTTHUMP00000009563; OTTHUMP00000009564; Stem cell protein; T cell acute lymphocytic leukemia 1; T cell acute lymphocytic leukemia 1 protein; T cell leukemia/lymphoma 5 protein; T-cell leukemia/lymphoma protein 5; Tal 1; Tal 1 product; TAL 1 protein; TAL-1; TAL1_HUMAN; TCL 5; tal-1 product;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TAL1-1259HCL	Recombinant Human TAL1 293 Cell Lysate	HEK293	Non		Inquiry
Human	TAL1-2749H	Recombinant Human TAL1 Protein, His-tagged	E.coli	His	Pro29-Arg331	Inquiry
Zebrafish	TAL1-12439Z	Recombinant Zebrafish TAL1	Mammalian Cell	His		Inquiry
Chicken	TAL1-6904C	Recombinant Chicken TAL1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

TAL1 involved in several pathways and played different roles in them. We selected most pathways TAL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TAL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

TAL1 has several biochemical functions, for example, E-box binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAL1 itself. We selected most functions TAL1 had, and list some proteins which have the same functions with TAL1. You can find most of the proteins on our site.

Function	Related Protein
E-box binding	MYOG;TWIST1;PER1;NEUROD1;ZEB1;GATA3;NEUROG2;LMO2;ATOH8
RNA polymerase II core promoter sequence-specific DNA binding	HNF4A;MTF1;H3F3A;TCF7L2;TP53;RUNX2;SMAD1;EP300;GATA1
RNA polymerase II distal enhancer sequence-specific DNA binding	NR2F6;CDX2;SPI1;PROP1;PBX3;PAX4;NFKB1;CREB1;ATF2
RNA polymerase II regulatory region sequence-specific DNA binding	GATA4;RFX6;SKINT8;TAL2;PHOX2A;PHF21B;NR1I2;PRDM15;ZNF792
RNA polymerase II transcription factor activity, sequence-specific DNA binding	JUN;SIX1A;ELF5;ZNF576;ATF5A;PAX6B;FOXP3A;SOX9A;ZNF131
RNA polymerase II transcription factor binding	SPOP;ATF4;XBP1;NFATC1;CHST13;GFI1B;GATA5;TP53;TAL1
chromatin binding	SATB1;HIST2H3C1;SETD7;HMG20A;KLF14;JUN;EP300;HIF1AB;PARP1
enzyme binding	PCCA;AKIRIN2;GOLPH3;MAPT;DVL1;CYP2A6;SPDL1;P4HB;CCND1
histone deacetylase binding	HDAC3;HDAC4;HDAC1;NUDT21;NACC2;SIX3;DDX20;NCOR1;KAT2A
protein binding	RPRD1B;ALDOB;YWHAB;FAM206A;FANCG;TRIM71;ARL16;NR2F2;OAZ2
protein heterodimerization activity	NEFL;UGT1A2;JAM2A;MAP3K7;H2AFY;SAE1;HGF;SOX17;Bcl2a1b
transcription factor activity, sequence-specific DNA binding	ZNF238;PPARAB;ZFP629;HOXA4;CREBL2;CSRNP3;FOXJ1A;ZNF227;ZNF831
transcription regulatory region DNA binding	GATA3;CARM1;RFX3;FOXH1;TCF7L1B;ZNF649;LEF1;NKX2-5;GATA6

TAL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAL1.

TCF3; TCF12; Lmo2; ETS1; RUNX1; CDK9; TRIM33

Research Area

Intracellular Signaling Molecules in Angiogenesis

Hemangioblast Markers

Transcription Factors in the Akt Pathway

Cancer Stem Cell Transcription Factors

Hematopoietic Stem Cell Transcription Factors and Regulators

Hemangioblast Transcription Factors

Mesodermal Lineage Markers

Karrman, K; Kjeldsen, E; et al. The t(X;7)(q22;q34) in paediatric T-cell acute lymphoblastic leukaemia results in overexpression of the insulin receptor substrate 4 gene through illegitimate recombination with the T-cell receptor beta locus. BRITISH JOURNAL OF HAEMATOLOGY 144:546-551(2009).

Biggs, JS; Wan, J; et al. Transcription factor binding to a putative double e-box motif represses CYP3A4 expression in human lung cells. MOLECULAR PHARMACOLOGY 72:514-525(2007).