• Official Full Name

    T-box 21

  • Overview

    This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
  • Synonyms

    TBX21; T-box 21; TBET; T-PET; T-bet; TBLYM; T-box transcription factor TBX21; T-box protein 21; T-box expressed in T cells; transcription factor TBLYM; T-cell-specific T-box transcription factor T-bet;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TBX21-195H Recombinant Human TBX21 protein, T7/His-tagged E.coli T7/His
Human TBX21-3141H Recombinant Human TBX21, GST-tagged E.coli GST 1-328aa
Human TBX21-196H Recombinant Human TBX21 Protein, His-tagged E.coli His Phe167~Gln423
Human TBX21-1747HCL Recombinant Human TBX21 cell lysate N/A
Human TBX21-2143H Recombinant Human TBX21 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TBX21-3024H Recombinant Human TBX21 protein, His-tagged E.coli His 1-328 aa
Human TBX21-79H Recombinant Human TBX21 Protein, His-tagged E.coli His
Human TBX21-125HFL Active Recombinant Full Length Human TBX21 Protein, C-Flag-tagged Mammalian cells Flag
Human TBX21-5839H Recombinant Human TBX21 Protein (Met11-Asn535), C-His tagged E.coli C-His Met11-Asn535
Human TBX21-2163H Recombinant Human TBX21 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TBX21-2163H-B Recombinant Human TBX21 Protein Pre-coupled Magnetic Beads HEK293
Mouse Tbx21-6321M Recombinant Mouse Tbx21 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Tbx21-1498M Recombinant Mouse Tbx21 protein, His & T7-tagged E.coli His/T7 Lys160~Arg399 (Accession # Q9JKD8)
Rat Tbx21-1499R Recombinant Rat Tbx21 protein, His & T7-tagged E.coli His/T7 Leu241~Arg493 (Accession # D3ZCM2)
Zebrafish TBX21-7648Z Recombinant Zebrafish TBX21 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

TBX21 involved in several pathways and played different roles in them. We selected most pathways TBX21 participated on our site, such as Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with TBX21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Inflammatory bowel disease (IBD)STAT3;IL18;IL22;SMAD3;RELA;TGFB3;IL17F;HLA-DPB1;H2-AA

TBX21 has several biochemical functions, for example, transcription factor activity, sequence-specific DNA binding, transcription regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TBX21 itself. We selected most functions TBX21 had, and list some proteins which have the same functions with TBX21. You can find most of the proteins on our site.

Function Related Protein
transcription factor activity, sequence-specific DNA bindingNFATC2;POU6F1;ZNF287;ZNF493;ZNF238;ZKSCAN1;NFIC;NFIA;ELF3
transcription regulatory region DNA bindingHDAC1;KLF2A;XRCC6;SFPQ;Arid4b;GABPB1;ZFHX3;PAX2;NR1D1

TBX21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBX21 here. Most of them are supplied by our site. Hope this information will be useful for your research of TBX21.


Research Area

Related articles

Oakley, MS; Sahu, BR; et al. T-bet modulates the antibody response and immune protection during murine malaria. EUROPEAN JOURNAL OF IMMUNOLOGY 44:2680-2691(2014).
Wu, SY; Zhao, HJ; et al. GTS-21, an alpha 7-nicotinic acetylcholine receptor agonist, modulates Th1 differentiation in CD4(+) T cells from patients with rheumatoid arthritis. EXPERIMENTAL AND THERAPEUTIC MEDICINE 8:557-562(2014).
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