|Official Full Name||transcription factor 12|
|Background||The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.|
|Synonyms||TCF12; transcription factor 12; bHLHb20; HEB; helix loop helix transcription factor 4; HsT17266; HTF4; TCF-12; E-box-binding protein; DNA-binding protein HTF4; transcription factor HTF-4; helix-loop-helix transcription factor 4; class B basic helix-loop-h|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
tcf12 involved in several pathways and played different roles in them. We selected most pathways tcf12 participated on our site, such as CDO in myogenesis, Developmental Biology, Id Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with tcf12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|CDO in myogenesis||CDH2; CTNNA2; BNIP2; BOC; SPAG9; CDH4; MEF2AA; TCF3A; MYOD1; MEF2B|
|Developmental Biology||RASGEF1A; GPC1B; NRTN; KIF4A; ARPC1B; EFNB3B; ITGB1B.1; LGI3; NRP2; CEBPB|
|Id Signaling Pathway||PAX2; TCF12; MYOG; TCF3B; IFI16; ACVRL1; MYOD1; MYF6; KDR; MSC|
|Myogenesis||CDON; SPAG9; MYF6; TCF12; CDH4; BOC; BNIP2; MEF2AA; TCF4; TCF3A|
tcf12 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, SMAD binding, bHLH transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by tcf12 itself. We selected most functions tcf12 had, and list some proteins which have the same functions with tcf12. You can find most of the proteins on our site.
|RNA polymerase II core promoter proximal region sequence-specific DNA binding||GCM1; NPAS4; MZF1; MXD1; MYBL2; NKX2-5; HOXA5; POU1F1; ELF1; H2AFZ|
|SMAD binding||FOXH1; MAGI2; HIPK2; SKILB; TGFBR3; SMURF2; CREBBP; TGFBR1; EP300; TCF12|
|bHLH transcription factor binding||PSMD9; ISL1; USF2; TWIST1; IKZF4; TCF3B; HAND1; TCF3; TCF3A; SOX9|
|enhancer binding||ARNT; RAI1; TIPARP; SMAD2; AHR; SMAD3; SOX9; SP1; FOXH1; ELL3|
|protein binding||ZBTB32; TAX1BP1; THSD4; PDIA6; CHORDC1; TMPRSS4; EXOSC10; NTN4; CACNA1SB; RAI1|
|protein heterodimerization activity||SYCP2; CLCF1; PDGFA; PPARD; NFE2L2A; Fzd4; HIST1H2A9; UGT1A2; SOX32; SMAD4|
|protein homodimerization activity||GTF2A2; CAT; GPD1B; GRHPR; CIB2; DAXX; LDB1; ALS2; RAP1GAP; TBX18|
|transcription factor activity, sequence-specific DNA binding||RHOXF1; SMAD3; GATAD2B; DBPB; FOXF2A; HLFA; USF2; ZNF239; TGIF2; SLAMF7|
|transcription factor binding||TBX5; HEY1; GPX3; DOT1L; RPS3; FOXO1; DDX3X; IRF4; MYOCD; PITX2|
|contributes_to transcription regulatory region DNA binding||NFYB; TCF12; NR1H3; HAND1; RXRA; HDAC4; NFYA; TCF3; NFYC; HDAC5|
|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding||HIF1A; ONECUTL; ETV4; ESR1; SIX1; OTX2; SPI1; TP73; POU4F3; NEUROD1|
tcf12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tcf12 here. Most of them are supplied by our site. Hope this information will be useful for your research of tcf12.
HEXIM2; MAPKBP1; CRCP; STK16; PSMA1; SRI; STAT5A