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Official Full Name transcription factor 12
Background The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Synonyms TCF12; transcription factor 12; bHLHb20; HEB; helix loop helix transcription factor 4; HsT17266; HTF4; TCF-12; E-box-binding protein; DNA-binding protein HTF4; transcription factor HTF-4; helix-loop-helix transcription factor 4; class B basic helix-loop-h
    • Species :
    • Chicken
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TCF12-1183HCL Recombinant Human TCF12 293 Cell Lysate HEK293 N/A
    Human TCF12-3157H Recombinant Human TCF12, His-tagged E.coli His
    Human TCF12-582H Recombinant Human TCF12 Protein, His-tagged E.coli His
    Rat TCF12-5988R Recombinant Rat TCF12 Protein Mammalian Cell His
    Chicken TCF12-6927C Recombinant Chicken TCF12 Mammalian Cell His
    Zebrafish TCF12-12825Z Recombinant Zebrafish TCF12 Mammalian Cell His

    tcf12 involved in several pathways and played different roles in them. We selected most pathways tcf12 participated on our site, such as CDO in myogenesis, Developmental Biology, Id Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with tcf12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    CDO in myogenesis CDH2; CTNNA2; BNIP2; BOC; SPAG9; CDH4; MEF2AA; TCF3A; MYOD1; MEF2B
    Developmental Biology RASGEF1A; GPC1B; NRTN; KIF4A; ARPC1B; EFNB3B; ITGB1B.1; LGI3; NRP2; CEBPB
    Id Signaling Pathway PAX2; TCF12; MYOG; TCF3B; IFI16; ACVRL1; MYOD1; MYF6; KDR; MSC
    Myogenesis CDON; SPAG9; MYF6; TCF12; CDH4; BOC; BNIP2; MEF2AA; TCF4; TCF3A

    tcf12 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, SMAD binding, bHLH transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by tcf12 itself. We selected most functions tcf12 had, and list some proteins which have the same functions with tcf12. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GCM1; NPAS4; MZF1; MXD1; MYBL2; NKX2-5; HOXA5; POU1F1; ELF1; H2AFZ
    bHLH transcription factor binding PSMD9; ISL1; USF2; TWIST1; IKZF4; TCF3B; HAND1; TCF3; TCF3A; SOX9
    enhancer binding ARNT; RAI1; TIPARP; SMAD2; AHR; SMAD3; SOX9; SP1; FOXH1; ELL3
    protein binding ZBTB32; TAX1BP1; THSD4; PDIA6; CHORDC1; TMPRSS4; EXOSC10; NTN4; CACNA1SB; RAI1
    protein heterodimerization activity SYCP2; CLCF1; PDGFA; PPARD; NFE2L2A; Fzd4; HIST1H2A9; UGT1A2; SOX32; SMAD4
    protein homodimerization activity GTF2A2; CAT; GPD1B; GRHPR; CIB2; DAXX; LDB1; ALS2; RAP1GAP; TBX18
    transcription factor activity, sequence-specific DNA binding RHOXF1; SMAD3; GATAD2B; DBPB; FOXF2A; HLFA; USF2; ZNF239; TGIF2; SLAMF7
    transcription factor binding TBX5; HEY1; GPX3; DOT1L; RPS3; FOXO1; DDX3X; IRF4; MYOCD; PITX2
    contributes_to transcription regulatory region DNA binding NFYB; TCF12; NR1H3; HAND1; RXRA; HDAC4; NFYA; TCF3; NFYC; HDAC5
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding HIF1A; ONECUTL; ETV4; ESR1; SIX1; OTX2; SPI1; TP73; POU4F3; NEUROD1

    tcf12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tcf12 here. Most of them are supplied by our site. Hope this information will be useful for your research of tcf12.


    di Rocco, F; Baujat, G; et al. Clinical spectrum and outcomes in families with coronal synostosis and TCF12 mutations. EUROPEAN JOURNAL OF HUMAN GENETICS 22:1413-1416(2014).
    Wang, P; Cui, J; et al. Differential expression of microRNAs in 2-cell and 4-cell mouse embryos. ZYGOTE 22:455-461(2014).

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