TFAP2B
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Official Full Name
transcription factor AP-2 beta (activating enhancer binding protein 2 beta) -
Overview
This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with;other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and;suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members;differ in their expression patterns and binding affinity for different promoters. This protein functions as both a;transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting;that this gene functions in the differentiation of neural crest cell derivatives. -
Synonyms
TFAP2B;transcription factor AP-2 beta (activating enhancer binding protein 2 beta);transcription factor AP 2 beta (activating enhancer binding protein 2 beta);transcription factor AP-2-beta;AP2 B;Activating enhancer binding protein 2 beta;AP 2B;AP2B;AP2beta;MGC21381;OTTHUMP00000039925;TFAP 2B;Transcription factor AP 2 beta;Transcription factor AP2 beta;AP2-beta;OTTHUMP00000016595;activating enhancer-binding protein 2-beta;AP-2B;AP2-B
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TFAP2B-3193H | Recombinant Human TFAP2B, GST-tagged | E.coli | Human | GST | C-term-350aa | |
| TFAP2B-2570Z | Recombinant Zebrafish TFAP2B | Mammalian Cells | Zebrafish | His |
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| TFAP2B-3056Z | Recombinant Zebrafish TFAP2B | Mammalian Cells | Zebrafish | His |
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| TFAP2B-586H | Recombinant Human TFAP2B Protein, His-tagged | E.coli | Human | His |
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| TFAP2B-6457C | Recombinant Chicken TFAP2B | Mammalian Cells | Chicken | His |
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| TFAP2B-3653H | Recombinant Human TFAP2B protein, His-tagged | E.coli | Human | His |
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Involved Pathway
TFAP2B involved in several pathways and played different roles in them. We selected most pathways TFAP2B participated on our site, such as Neural Crest Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFAP2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neural Crest Differentiation | SOX5,PMP22,CDH6,TFAP2A,CDH7,MYB,OLIG1,LHX2,MIA,PHOX2B |
Protein Function
TFAP2B has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter sequence-specific DNA binding,RNA polymerase II transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TFAP2B itself. We selected most functions TFAP2B had, and list some proteins which have the same functions with TFAP2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | CBFA2T2,EID1,NCOR2,TAF9B,ELK3,MNT,JUB,SSX5,NR0B2A,AEBP2 |
| transcription coactivator activity | RNF20,MED12,ARID1A,YAF2,TAF6L,ARNT,MYCBP,PIAS1,PML,CDK7 |
| DNA binding | UBP1,SOX3,ANO9A,ZSCAN18,ZFP131,ZNF189,SCML2,HNRPK,ZFP523,ZEB1B |
| protein binding | STAG3,MAMSTR,FAM19A1,PSPC1,ARPIN,ARHGEF10,WDFY3,PICALM,DCD,Icosl |
| protein heterodimerization activity | SOX15,UGT1A6,ADRA2A,SLC3A1,MYF5,CREB3L3,NEUROD1,AXL,HIST1H2B7,PAFAH1B3 |
| enhancer sequence-specific DNA binding | SOX11,KLF7B,ATF2,SOX9,GATA3,GATA1,ISL1,GATA2,LDB1,XBP1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | CREB3L2,SOX12,GLI2,MIXL1,EBF2,HOXD13,Ar,POU1F1,ATF2,PITX3 |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | CD27,TNFSF14,NAIP1,NOL3,AVP,TNFAIP8,SNCA,SERPINB1A,C1QL4L,LEF1 |
| RNA polymerase II transcription corepressor activity | ELANE,UXT,HEYL,BEND6,SOX3,SIN3AA,TCERG1,HDAC1,CTBP1,SIN3A |
Interacting Protein
TFAP2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFAP2B here. Most of them are supplied by our site. Hope this information will be useful for your research of TFAP2B.
CITED2;UBE2I;HIST1H2AC;VPS11
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