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Official Full Name transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
Background TLE4 (transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)) is a protein-coding gene. Diseases associated with TLE4 include rabies, and bipolar disorder, and among its related super-pathways are Constitutive Signaling by NOTCH1 PEST Domain Mutants and Signaling by GPCR. GO annotations related to this gene include transcription corepressor activity and molecular_function. An important paralog of this gene is AES.
Synonyms TLE4; transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila); ESG; BCE1; ESG4; GRG4; BCE-1; E(spI)
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TLE4-1785HCL Recombinant Human TLE4 cell lysate N/A
    Human TLE4-3251H Recombinant Human TLE4, GST-tagged E.coli GST
    Mouse TLE4-16815M Recombinant Mouse TLE4 Protein Mammalian Cell His
    Chicken TLE4-5810C Recombinant Chicken TLE4 Mammalian Cell His

    tle4 involved in several pathways and played different roles in them. We selected most pathways tle4 participated on our site, such as Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, Formation of the beta-catenin:TCF transactivating complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with tle4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Deactivation of the beta-catenin transactivating complex PYGO1; TLE3; SOX9A; ASH2L; SOX7; C; SOX4A; SOX6; SOX4B; CTBP1
    Degradation of beta-catenin by the destruction complex TLE3B; TLE2; FAM123B; TLE3; CTBP2; TLE1; CTBP1; AES; TLE4
    Formation of the beta-catenin:TCF transactivating complex H3F3B.1; TLE1; TLE3B; TLE3; LEO1; ASH2L; BCL9L; PYGO1; TLE4; BCL9
    NOTCH1 Intracellular Domain Regulates Transcription HEYL; TLE2; TUBB3; TLE4; HEY1; HEY2; TLE1; TLE3
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription TLE1; TCF4; HBP1; TLE2; T; CYR61; KCNIP4; TLE4; ZCCHC12; KRT1
    Repression of WNT target genes TLE3; AES; TLE2; TLE3B; TLE4
    Signal Transduction KAL1; NPHP4; CCL35.1; PROK1; RHOJ; BOC; KLHL12; ACKR4; SOX9A; RLN1

    tle4 has several biochemical functions, for example, chromatin binding, molecular_function, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by tle4 itself. We selected most functions tle4 had, and list some proteins which have the same functions with tle4. You can find most of the proteins on our site.

    Function Related Protein
    chromatin binding RAN; SKOR2; HMGN5; KLF6A; RELB; EBF2; NKX2; KDM1A; CAPNS2; TRP63
    molecular_function FLOT2B; POM121L2; ACTBL2; MUC12; PRL6A1; DPCR1; TSPAN32; GOLGA7BA; LRRC23; GM14819
    protein binding CRBN; FLT4; MAP2; NMB; CYBRD1; CEP57L1; RPS27A; ORC2L; STAU1; LYN
    repressing transcription factor binding TBP; TLE4; HDAC4; NOC2L; HDAC1; RUNX2; KAT5; CTNNB1; DDX20; MYC
    transcription corepressor activity CBFA2T2; LHX9; MXI1; SAP30; PIAS1; TRIM28; JUNB; NAB2; KLF12; TGIF1
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding THRA; MEF2C; FOXF1; NKX2-5; SRF; GATA4; NFIX; FOXC2; JUN; HNF4A

    tle4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tle4 here. Most of them are supplied by our site. Hope this information will be useful for your research of tle4.

    brnQ3; mfd; tcaC1

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