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TLK2

  • Official Full Name

    tousled-like kinase 2

  • Overview

    The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.
  • Synonyms

    TLK2; tousled-like kinase 2; serine/threonine-protein kinase tousled-like 2; MGC44450; PKU ALPHA; serine/threonine kinase; PKU-ALPHA;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • GST
  • His
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TLK2-247H Active Recombinant Human TLK2(388-end) Protein, N-His-tagged Sf21 His 388-end
Human TLK2-446H Recombinant Human Tousled-like Kinase 2, GST-tagged, Active Sf9 Insect Cell GST
Human TLK2-30422TH Recombinant Human TLK2 N/A
Human TLK2-270H Recombinant Human TLK2, Gly & Pro tagged Insect Cell His
Human TLK2-3253H Recombinant Human TLK2, GST-tagged E.coli GST 453-772aa
Human TLK2-1362H Recombinant Human TLK2 protein(Leu397-Asn772), His&GST-tagged Insect Cells N-His&GST Leu397-Asn772
Human TLK2-001HCL Recombinant Human TLK2 cell lysate Insect Cell N/A
Human TLK2-554HCL Recombinant Human TLK2 cell lysate Insect Cell N/A
Human TLK2-1108H Recombinant Human TLK2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TLK2-1304H Recombinant Human TLK2 protein(Leu397-Asn772) Insect Cells N/A Leu397-Asn772
Human TLK2-5591HF Active Recombinant Full Length Human TLK2 Protein, GST-tagged Insect (sf21) GST 1-750
Human TLK2-5589H Recombinant Human TLK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Tlk2-6450M Recombinant Mouse Tlk2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish TLK2-6171Z Recombinant Zebrafish TLK2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TLK2 Related Articles

TLK2 involved in several pathways and played different roles in them. We selected most pathways TLK2 participated on our site, such as DNA damage response, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DNA damage responseTLK2;HUS1B;GADD45A;CDK5;DDB2;GADD45G;RAD9A;RAD17;RAD1

TLK2 has several biochemical functions, for example, ATP binding, protein binding, protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLK2 itself. We selected most functions TLK2 had, and list some proteins which have the same functions with TLK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCCT6B;MYO1F;SLC27A5;HSPA6;YARS;ATP9A;GLUL;ATP2A1L;MSH5
protein bindingSF3A3;cgr2b;GORASP1;SAP30BP;TRAF7;ZNF567;RAD51L3;TMED9;ATPAF2
protein serine/threonine kinase activityMAP3K9;HUNK;STK35L;CSNK2A2;TSSK5;NEK6;MAPKAPK5;TGFBR1;MAPK11

TLK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLK2.

IRF4; IRF7; ASF1B; RPS6KA1

Garrote, AM; Redondo, P; et al. Purification, crystallization and preliminary X-ray diffraction analysis of the kinase domain of human tousled-like kinase 2. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 70:354-357(2014).
Shanmugam, PST; Dayton, RD; et al. Recombinant AAV9-TLK1B Administration Ameliorates Fractionated Radiation-Induced Xerostomia. HUMAN GENE THERAPY 24:604-612(2013).
  • Q&As
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