• Official Full Name

    toll-like receptor 6

  • Overview

    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.
  • Synonyms

    TLR6; toll-like receptor 6; CD286; OTTHUMP00000218187; CD286 antigen; TLR 6; Toll like receptor 6 precursor; OTTHUMP00000218188; OTTHUMP00000158730;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Rhesus monkey
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • C
  • His
  • Fc
  • Fc Chimera
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TLR6-422H Active Recombinant Human TLR6, Fc Chimera CHO Fc Chimera
Human TLR6-3259H Recombinant Human TLR6, His-tagged E.coli His 143-383aa
Human TLR6-781H Recombinant Human TLR6 protein, His & T7-tagged E.coli His/T7 Tyr608~Ser796 (Accession # Q9Y2C9)
Human TLR6-1044HCL Recombinant Human TLR6 293 Cell Lysate HEK293 N/A
Human TLR6-1488H Recombinant Human TLR6 Protein (Gly143-Ile383), N-His tagged E.coli N-His Gly143-Ile383
Human TLR6-3891H Recombinant Human TLR6 Protein (Met1-Leu586), C-His tagged Mammalian cells C-His Met1-Leu586
Mouse Tlr6-444M Active Recombinant Mouse Tlr6, Fc Chimera Sf21 Insect Cell Fc Chimera
Mouse Tlr6-782M Recombinant Mouse Tlr6 protein, His & T7-tagged E.coli His/T7 Ala17~Met239 (Accession # Q9EPW9)
Mouse Tlr6-2433M Recombinant Mouse Toll-like Receptor 6, Fc Chimera Human Cell Fc
Rhesus monkey TLR6-1676R Recombinant Rhesus Monkey TLR6 Protein HEK293 N/A
Rhesus monkey TLR6-1677R Recombinant Rhesus Monkey TLR6 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey TLR6-1678R Recombinant Rhesus Monkey TLR6 Protein, hIgG4-tagged HEK293 hIgG4
Rhesus Macaque TLR6-4735R Recombinant Rhesus monkey TLR6 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TLR6-4549R Recombinant Rhesus Macaque TLR6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TLR6-4549R-B Recombinant Rhesus Macaque TLR6 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Tlr6 Related Articles
  • Tlr6 Related Research Area

Tlr6 involved in several pathways and played different roles in them. We selected most pathways Tlr6 participated on our site, such as Activated TLR4 signalling, Chagas disease (American trypanosomiasis), Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tlr6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activated TLR4 signallingALCAMB;DUSP4;DUSP3;MAP3K8;RIPK3;UBE2V1;DHX9;S100B;TNIP2
Chagas disease (American trypanosomiasis)IKBKB;PIK3CB;PPP2R2B;CASP8;TGFB2;CD247;GNA14;CCL3;GNAI2
Diseases associated with the TLR signaling cascadeTICAM1;TLR6;TIRAP;TLR10
Diseases of Immune SystemTLR6;TIRAP;TLR10
IRAK4 deficiency (TLR2/4)TLR6;TIRAP

Tlr6 has several biochemical functions, for example, Toll-like receptor 2 binding, diacyl lipopeptide binding, lipopeptide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tlr6 itself. We selected most functions Tlr6 had, and list some proteins which have the same functions with Tlr6. You can find most of the proteins on our site.

Function Related Protein
Toll-like receptor 2 bindingTLR1;TLR6;TIRAP
diacyl lipopeptide bindingTLR2;TLR6
lipopeptide bindingCD1D2;CD1E;CD1A;CD1D;TLR6;CD1B;CD1d1;CD1C
protein bindingTRIM41;ZBTB22;PEA15;CLEC16A;FBXW9;ZNF232;CHMP1B;KIF13B;CREB5
protein heterodimerization activityFZD1;SMAD2;HIST1H2B5;ENO3;H2AFY2;H2AFVA;CREB3L3;ADD1;NOTCH4
transmembrane signaling receptor activityOR12D3;GPR133;TNFRSF11A;CLEC2D;OR2A4;FCAMR;NRXN2;TLR2-1;SIGLEC8

Tlr6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tlr6 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tlr6.

Ammerdorffer, A; Schoffelen, T; et al. Recognition of Coxiella burnetii by Toll-like Receptors and Nucleotide-Binding Oligomerization Domain-like Receptors. JOURNAL OF INFECTIOUS DISEASES 211:978-987(2015).
Zhang, XJ; Xu, J; et al. Expression and function of Toll-like receptors in peripheral blood mononuclear cells from patients with ovarian cancer. CANCER IMMUNOLOGY IMMUNOTHERAPY 64:275-286(2015).
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