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Active Recombinant Mouse Fn-14, Fc-tagged

Cat.No. : Tnfrsf12a-42M
Product Overview : Produced in HEK 293 cells. The extracellular domain of mouse Fn14 (aa 1-75) is fused to the Fc portion of human IgG1.
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  • Gene Information
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Source : HEK 293 cells
Species : Mouse
Tag : Fc
Form : Lyophilized. Contains PBS. Reconstitute with 50 μL of sterile water for a 1 mg/mL solution. Further dilutions should be made with medium containing 5% fetal calf serum. After reconstitution, prepare aliquots and store at -20°C.
Bio-activity : Inhibits TWEAK-mediated killing of Kym-1 target cells. Binds to human and mouse TWEAK.
Molecular Mass : ~34 kDa as determined by SDS-PAGE
Endotoxin : <0.1 eu/μg of purified protein (lal test).>
Purity : >95% as determined by SDS-PAGE.
Usage : For in vitro research use only. Not for use in diagnostics or in humans.
Storage : Store at -20°C. After reconstitution, prepare aliquots and store at -20°C.
Warning : No warranties, expressed or implied, are made regarding the use of this product. Creative Biomart is not liable for any damage, personal injury, or economic loss caused by this product.
Gene Name : Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a [ Mus musculus ]
Official Symbol : Tnfrsf12a
Synonyms : TNFRSF12A; tumor necrosis factor receptor superfamily, member 12a; tumor necrosis factor receptor superfamily member 12A; tweak-receptor; FGF-inducible 14; type I transmembrane protein Fn14; fibroblast growth factor regulated protein 2; fibroblast growth factor-regulated protein 2; fibroblast growth factor-inducible immediate-early response protein 14; Fn14; HPIP; C87282; TweakR; TWEAK-R; AI255180;
Gene ID : 27279
mRNA Refseq : NM_001161746
Protein Refseq : NP_001155218
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function : protein binding; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can TNFRSF12A be a potential therapeutic target for cardiovascular diseases? 05/14/2022

Some studies suggest that TNFRSF12A may play a role in cardiovascular diseases, and targeting it could be a potential therapeutic strategy, but more research is needed.

Can TNFRSF12A be used as a diagnostic marker for certain diseases? 02/09/2021

Research indicates that elevated levels of TNFRSF12A may serve as a diagnostic marker for certain cancers, providing valuable information for disease detection.

Are there any FDA-approved drugs targeting TNFRSF12A? 05/10/2020

As of now, there are no FDA-approved drugs specifically targeting TNFRSF12A. However, research is ongoing to develop targeted therapies.

How is TNFRSF12A involved in inflammation? 01/31/2018

TNFRSF12A is known to modulate inflammatory responses, and dysregulation of its signaling pathways may contribute to chronic inflammatory conditions.

Can TNFRSF12A be targeted for immunotherapy in cancer treatment? 11/17/2017

TNFRSF12A is being explored as a potential target for immunotherapy in cancer, with studies investigating its role in modulating the immune response.

Customer Reviews (3)

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Reviews
11/26/2020

    The manufacturer's commitment to delivering excellent technical support further enhances the experience, offering timely resolutions to any challenges I may encounter.

    09/08/2019

      the TNFRSF12A protein surpasses expectations in terms of quality, meeting the rigorous demands of my experiments.

      06/16/2019

        With the TNFRSF12A protein and the manufacturer's support, I can confidently pursue my research goals and achieve meaningful outcomes.

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