Active Recombinant Human Fn-14, Fc-tagged

• Cat.No.: TNFRSF12A-41H
• Product Overview: Produced in HEK 293 cells. The extracellular domain of human Fn14 (aa 1-75) is fused at the C-terminus to the Fc portion of human IgG1 and a linker peptide (2 aa).

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Protein Length: 1-75 a.a.
• Form: Lyophilized. Contains PBS. Reconstitute with 50 μL of sterile water for a 1 mg/mL solution. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein. After reconstitution, prepare aliquots and store at -20°C.
• Bio-activity: Binds to human and mouse TWEAK.
• Molecular Mass: ~36 kDa for the chimeric protein as determined by SDS-PAGE
• Endotoxin: <0.1 eu/μg="" of="" purified="" protein="" (lal="" test).="">
• Purity: >95% as determined by SDS-PAGE.
• Usage: For in vitro research use only. Not for use in diagnostics or in humans.
• Storage: Store at -20°C. After reconstitution, prepare aliquots and store at -20°C.
• Warning: No warranties, expressed or implied, are made regarding the use of this product. Creative Biomart is not liable for any damage, personal injury, or economic loss caused by this product.

Gene Information

• Gene Name: TNFRSF12A tumor necrosis factor receptor superfamily, member 12A [ Homo sapiens ]
• Official Symbol: TNFRSF12A
• Synonyms: TNFRSF12A; tumor necrosis factor receptor superfamily, member 12A; tumor necrosis factor receptor superfamily member 12A; CD266; FN14; TweakR; tweak-receptor; FGF-inducible 14; type I transmembrane protein Fn14; fibroblast growth factor-inducible immediate-early response protein 14; TWEAKR
• Gene ID: 51330
• mRNA Refseq: NM_016639
• Protein Refseq: NP_057723
• MIM: 605914
• UniProt ID: Q9NP84
• Chromosome Location: 16p13.3
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem
• Function: protein binding; receptor activity