TNKS Protein


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Official Full Name tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Background Tankyrase-1 is an enzyme that in humans is encoded by the TNKS gene.
Synonyms TNKS; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; tankyrase-1; PARP 5a; PARP5A; pART5; TIN1; TINF1; TNKS1; TANK1; TNKS-1; tankyrase I; poly [ADP-ribose] polymerase 5A; TRF1-interacting ankyrin-related ADP-ribose polymerase; PARPL; P
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TNKS-31498TH Recombinant Human TNKS Wheat Germ N/A
    Human TNKS-3327H Recombinant Human TNKS, GST-tagged E.coli GST
    Human TNKS-3328H Recombinant Human TNKS protein, GST-tagged Wheat Germ GST
    Mouse TNKS-17187M Recombinant Mouse TNKS Protein Mammalian Cell His
    Rhesus Macaque TNKS-4878R Recombinant Rhesus monkey TNKS Protein, His-tagged Mammalian Cell His
    Chicken TNKS-5912C Recombinant Chicken TNKS Mammalian Cell His
    Human TNKS-459H Recombinant Human TNKS Protein, His-tagged E.coli N-His

    TNKS involved in several pathways and played different roles in them. We selected most pathways TNKS participated on our site, such as Degradation of AXIN, Disease, Diseases of signal transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNKS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Degradation of AXIN TNKS; TNKS2; RNF146
    Diseases of signal transduction MIB1; RNF43; TTR; CPSF6; CTBP1; HEY1; KREMEN1; HEY2; RBP4; TNKS
    Regulation of Telomerase TNKS; DKC1; NR2F2; MXD1; SP3; PINX1; CMTM2A
    Signal Transduction MYO7A; FSTL1B; IFT52; STARD13; GHRB; NET1; SOX6; F11R.2; USP9; ARHGAP12B
    Signaling by WNT in cancer KREMEN1; RNF43; TNKS2; TNKS; KREMEN2
    Signaling by Wnt RSPO4; CDC73; RSPO3; TMED5; RSPO1; KLHL12; BCL9; AES; LGR5; C
    TCF dependent signaling in response to WNT HECW1; CBY1; BCL9; KREMEN1; SOX7; HECW1B; LGR5; WIF1; KLHL12; SOX9B

    TNKS has several biochemical functions, for example, NAD+ ADP-ribosyltransferase activity, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNKS itself. We selected most functions TNKS had, and list some proteins which have the same functions with TNKS. You can find most of the proteins on our site.

    Function Related Protein
    NAD+ ADP-ribosyltransferase activity PARP12; PARP11; GIG2K; PARP12A; PARP1; GIG2J; PARP6; PARP8; ART5; GIG2O
    protein binding CCDC94; FAM46B; MORF4L1; MIF4GD; IRF2BP1; PRKCD; HSFY1; CCBE1; PIK3CD; NR3C1
    zinc ion binding C6AST4; RARAA; MID1; SP110; NR2F6B; S100A13; FHL3; MORC3; BTY; BTR06

    TNKS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNKS here. Most of them are supplied by our site. Hope this information will be useful for your research of TNKS.

    TERF1; FNBP1; Axin1; xav939; CENPJ; nad+

    Shebzukhov, YV; Lavrik, IN; et al. Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients. CANCER IMMUNOLOGY IMMUNOTHERAPY 57:871-881(2008).
    Kuimov, AN; Kuprash, DV; et al. Cloning and characterization of TNKL, a member of tankyrase gene family. GENES AND IMMUNITY 2:52-55(2001).

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