TNKS involved in several pathways and played different roles in them. We selected most pathways TNKS participated on our site, such as Degradation of AXIN, Disease, Diseases of signal transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNKS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Degradation of AXIN |
TNKS; TNKS2; RNF146 |
| Disease |
ANTXR2; MTRR; PSTPIP2; PDCD6IP; PSIP1; AP1B1; CFTR; FDX1; HDAC5; IPO5 |
| Diseases of signal transduction |
MIB1; RNF43; TTR; CPSF6; CTBP1; HEY1; KREMEN1; HEY2; RBP4; TNKS |
| Regulation of Telomerase |
TNKS; DKC1; NR2F2; MXD1; SP3; PINX1; CMTM2A |
| Signal Transduction |
MYO7A; FSTL1B; IFT52; STARD13; GHRB; NET1; SOX6; F11R.2; USP9; ARHGAP12B |
| Signaling by WNT in cancer |
KREMEN1; RNF43; TNKS2; TNKS; KREMEN2 |
| Signaling by Wnt |
RSPO4; CDC73; RSPO3; TMED5; RSPO1; KLHL12; BCL9; AES; LGR5; C |
| TCF dependent signaling in response to WNT |
HECW1; CBY1; BCL9; KREMEN1; SOX7; HECW1B; LGR5; WIF1; KLHL12; SOX9B |
TNKS has several biochemical functions, for example, NAD+ ADP-ribosyltransferase activity, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNKS itself. We selected most functions TNKS had, and list some proteins which have the same functions with TNKS. You can find most of the proteins on our site.
| Function |
Related Protein |
| NAD+ ADP-ribosyltransferase activity |
PARP12; PARP11; GIG2K; PARP12A; PARP1; GIG2J; PARP6; PARP8; ART5; GIG2O |
| protein binding |
CCDC94; FAM46B; MORF4L1; MIF4GD; IRF2BP1; PRKCD; HSFY1; CCBE1; PIK3CD; NR3C1 |
| zinc ion binding |
C6AST4; RARAA; MID1; SP110; NR2F6B; S100A13; FHL3; MORC3; BTY; BTR06 |
TNKS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNKS here. Most of them are supplied by our site. Hope this information will be useful for your research of TNKS.
TERF1; FNBP1; Axin1; xav939; CENPJ; nad+
Shebzukhov, YV; Lavrik, IN; et al. Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients. CANCER IMMUNOLOGY IMMUNOTHERAPY 57:871-881(2008).
Kuimov, AN; Kuprash, DV; et al. Cloning and characterization of TNKL, a member of tankyrase gene family. GENES AND IMMUNITY 2:52-55(2001).
