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TNKS2

Official Full Name

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Synonyms

TNKS2; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2; tankyrase-2; PARP 5b; PARP 5c; PARP5B; PARP5C; pART6; TANK2; TNKL; TNKS-2; tankyrase 2; tankyrase II; tankyrase-like protein; tankyrase-related protein; poly [ADP-ribose] polymerase 5B; TRF1-interacting ankyrin-related ADP-ribose polymerase 2; PARP-5b; PARP-5c;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads
Assay Kits

Species

Chicken
Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TNKS2-8199H	Recombinant Human TNKS2 protein, His-tagged	E.coli	His	Ser959~Gly1166	Inquiry
Human	TNKS2-3329H	Recombinant Human TNKS2 protein, GST-tagged	Wheat Germ	GST	1068 a.a. - 1166 a.a.	Inquiry
Human	TNKS2-3328H	Recombinant Human TNKS2, GST-tagged	E.coli	GST	800-900aa	$319 / 25ug
Mouse	TNKS2-17189M	Recombinant Mouse TNKS2 Protein	Mammalian Cell	His		Inquiry
Mouse	TNKS2-9492M-B	Recombinant Mouse TNKS2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	TNKS2-9492M	Recombinant Mouse TNKS2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	TNKS2-4879R	Recombinant Rhesus monkey TNKS2 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	TNKS2-4693R	Recombinant Rhesus Macaque TNKS2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	TNKS2-4693R-B	Recombinant Rhesus Macaque TNKS2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	TNKS2-5913C	Recombinant Chicken TNKS2	Mammalian Cell	His		Inquiry
	Kit-1884	TNKS2 Histone Ribosylation Assay Kit (Antibody Detection) I		N/A		Inquiry
	Kit-1887	TNKS2 Histone Ribosylation Assay Kit (Biotin-labeled NAD+) II		N/A		Inquiry
	Kit-1886	TNKS2 Histone Ribosylation Assay Kit (Biotin-labeled NAD+) I		N/A		Inquiry
	Kit-1885	TNKS2 Histone Ribosylation Assay Kit (Antibody Detection) II		N/A		Inquiry
	Kit-1888	TNKS2 Histone Ribosylation Colorometric Assay Kit		N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein
TNKS2 Related Research Area

TNKS2 involved in several pathways and played different roles in them. We selected most pathways TNKS2 participated on our site, such as Degradation of AXIN, Disease, Diseases of signal transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNKS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Degradation of AXIN	TNKS;TNKS2;RNF146
Disease	RDBP;CCR5;MTRR;LTF;FDX1L;SFTPB;CTBP2;TRIM24;OS9
Diseases of signal transduction	FGFR1OP2;FKBP1A;JAG1;CDK8;CCNC;TRIM24;TRAT1;TNKS2;JAG2
Signal Transduction	WIF1;CCL35.1;OPN1SW1;OPN1LW2;GHRB;ARHGAP31;RHOUA;NMBB;ANXA1C
Signaling by WNT in cancer	KREMEN1;KREMEN2;TNKS2;TNKS;RNF43
Signaling by Wnt	PYGO1;SOX9A;C;CCDC88C;AES;WIF1;SOX9B;TNKS;LGR4
TCF dependent signaling in response to WNT	PYGO1;SOX9A;RNF146;CDC73;RSPO3;SRY;TNKS;SOX13;TLE3B
XAV939 inhibits tankyrase, stabilizing AXIN

TNKS2 has several biochemical functions, for example, NAD+ ADP-ribosyltransferase activity, enzyme binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNKS2 itself. We selected most functions TNKS2 had, and list some proteins which have the same functions with TNKS2. You can find most of the proteins on our site.

Function	Related Protein
NAD+ ADP-ribosyltransferase activity	PARP9;GIG2O;PARP4;GIG2P;ART5;GIG2H;PARP15;PARP12;GIG2G
enzyme binding	ADORA2A;PDCD2;WWOX;EHHADH;TRAF2;TUT1;UBE2L3;UGT1A3;PARP4
metal ion binding	RHOT1A;PVALB8;SMAD2;PDE11A;EXT1C;ZNF131;ZNF547;FBXO30B;ZNF821
protein binding	PLXNC1;EMILIN1;TRAPPC5;FAM53C;ZFP161;PPIE;PTPRG;MARCH10;SRPK3

TNKS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNKS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNKS2.

Sh3bp2; SH3BP2; BCR; RAD54L; BABAM1

ADP-ribosyltransferases (ARTs)