TNKS2
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Official Full Name
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 -
Synonyms
TNKS2;tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2;tankyrase-2;PARP 5b;PARP 5c;PARP5B;PARP5C;pART6;TANK2;TNKL;TNKS-2;tankyrase 2;tankyrase II;tankyrase-like protein;tankyrase-related protein;poly [ADP-ribose] polymerase 5B;TRF1-interacting ankyrin-related ADP-ribose polymerase 2;PARP-5b;PARP-5c
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- GST
- His
- Non
- Avi
- Fc
Involved Pathway
TNKS2 involved in several pathways and played different roles in them. We selected most pathways TNKS2 participated on our site, such as Degradation of AXIN,Disease,Diseases of signal transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNKS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Diseases of signal transduction | FGFR1OP,KREMEN1,STRA6,CPSF6,CTBP1,HEYL,JAG1,DERL2,CTBP2,CDK8 |
| Signal Transduction | DRAP1,LPAR2A,ROR1,GPR37L1,CSHL1,TTC21B,GPR177,CHRDL1,MLN,GHRB |
| Signaling by Wnt | PYGO1,USP34,FAM123B,LGR5,C,ASH2L,TNKS,TMED5,KREMEN1,AES |
| Disease | FDX1L,GYG1,ELL,PACS1,CHMP4B,APOBEC3G,GYG2,RDBP,OPN1MW,ANTXR2 |
| TCF dependent signaling in response to WNT | LGR4,SOX4B,CBY1,KLHL12,SOX13,BCL9L,RSPO3,WIF1,SOX7,RSPO2 |
| Degradation of AXIN | TNKS,RNF146 |
| Signaling by WNT in cancer | RNF43,KREMEN2,TNKS,KREMEN1 |
Protein Function
TNKS2 has several biochemical functions, for example, NAD+ ADP-ribosyltransferase activity,enzyme binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNKS2 itself. We selected most functions TNKS2 had, and list some proteins which have the same functions with TNKS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | PIKFYVE,C6AST1,TRMT1,NEK1,LHX2A,HBBE1.1,ZNF7,ESCO2,RNF150A,ZNF583 |
| enzyme binding | PGR,CDK19,PCBP2,AKIRIN2,NOXA1,CBX4,KRT79,ITGB3,YWHAE,PLCE1 |
| NAD+ ADP-ribosyltransferase activity | PARP2,PARP12A,PARP9,GIG2H,CHAT1,CHAT2,GIG2F,GIG2O,TIPARP,GIG2J |
| protein binding | PBX2,APBB1,ANLN,CREBZF,PACSIN1,LRRC25,PIKFYVE,KLHDC4,COPS5,FANCI |
Interacting Protein
TNKS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNKS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNKS2.
Sh3bp2;SH3BP2;BCR;RAD54L;BABAM1
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