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TPM2

  • Official Full Name

    tropomyosin 2 (beta)

  • Overview

    This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    TPM2; tropomyosin 2 (beta); AMCD1, arthrogryposis multiplex congenital, distal, type 1; tropomyosin beta chain; DA1; tropomyosin-2; DA2B; NEM4; TMSB; AMCD1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TPM2-3442H Recombinant Human TPM2 protein, His-tagged E.coli His
Human TPM2-31627TH Recombinant Human TPM2 N/A
Human TPM2-31626TH Recombinant Human TPM2, His-tagged E.coli His 284 amino acids
Human TPM2-843HCL Recombinant Human TPM2 293 Cell Lysate HEK293 N/A
Human TPM2-3187H Recombinant Human TPM2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TPM2-6005H Recombinant Human TPM2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TPM2-317H Recombinant Human TPM2 Protien, GST-tagged E. coli GST 1-284 aa
Mouse TPM2-17257M Recombinant Mouse TPM2 Protein Mammalian Cell His
Mouse Tpm2-6599M Recombinant Mouse Tpm2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TPM2-9537M Recombinant Mouse TPM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TPM2-9537M-B Recombinant Mouse TPM2 Protein Pre-coupled Magnetic Beads HEK293
Rat TPM2-6242R Recombinant Rat TPM2 Protein Mammalian Cell His
Rat TPM2-5899R Recombinant Rat TPM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TPM2-5899R-B Recombinant Rat TPM2 Protein Pre-coupled Magnetic Beads HEK293
Canine TPM2-2144C Recombinant Canine TPM2 protein, His-tagged HEK293 His Gln 39 - Thr 281
Rhesus macaque TPM2-1014R Recombinant Rhesus macaque TPM2 protein, His-tagged HEK293 His Gln 31 - Thr 274
Zebrafish TPM2-346Z Recombinant Zebrafish TPM2 Mammalian Cell His
Chicken TPM2-6996C Recombinant Chicken TPM2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TPM2 Related Articles

TPM2 involved in several pathways and played different roles in them. We selected most pathways TPM2 participated on our site, such as Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Hypertrophic cardiomyopathy (HCM), which may be useful for your reference. Also, other proteins which involved in the same pathway with TPM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cardiac muscle contractionCACNG6;UQCR10;CACNB1;VMHCL;ACTC1A;COX5AA;TPM2;COX7A2A;VMHC
Adrenergic signaling in cardiomyocytesGNAI2;PPP2R2CA;MAPK14A;ATP2A2;CREB1A;PPP2R1A;ATF4B1;PPP2R3C;GNAI2A
Hypertrophic cardiomyopathy (HCM)ITGAV;PRKAA2;TPM4;ITGB3;CACNA2D3;PRKAB1;IGF1;TPM1;TGFB1
Dilated cardiomyopathySGCD;ITGA2B;TPM1;ITGA7;SGCB;ITGA6;TNNC1;GNAS;SLC8A1

TPM2 has several biochemical functions, for example, actin binding, structural constituent of muscle. Some of the functions are cooperated with other proteins, some of the functions could acted by TPM2 itself. We selected most functions TPM2 had, and list some proteins which have the same functions with TPM2. You can find most of the proteins on our site.

Function Related Protein
actin bindingCAP2;CCDC88A;MYHZ1.1;TBC1D21;MYBPC2;GCSAM;PALLD;MYH9A;MYH10
structural constituent of muscleMYOM1;CSRP3;TTN;DMD;DAG1;ASPH;ACTN3;MYBPC3;TPM2

TPM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPM2.

EPB41; MCC; Pafah1b1; Poc1b; Ccdc15; Zwint; ck024_mouse; SNAPIN; SKIL; MAST2; AKT1; MYH9; IQGAP1; CAPZA2; Tpm1; Actb; PPP1CB; GRB2

Schreckenbach, T; Schroder, JM; et al. Novel TPM3 mutation in a family with cap myopathy and review of the literature. NEUROMUSCULAR DISORDERS 24:117-124(2014).
Tang, HY; Beer, LA; et al. Protein isoform-specific validation defines multiple chloride intracellular channel and tropomyosin isoforms as serological biomarkers of ovarian cancer. JOURNAL OF PROTEOMICS 89:165-178(2013).
Zhang, JT; Wang, KJ; et al. Using Proteomic Approach to Identify Tumor-Associated Proteins as Biomarkers in Human Esophageal Squamous Cell Carcinoma. JOURNAL OF PROTEOME RESEARCH 10:2863-2872(2011).
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