TPR
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Official Full Name
translocated promoter region, nuclear basket protein -
Overview
This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5 end of this gene with several different kinase genes occur in some neoplasias. -
Synonyms
TPR;translocated promoter region, nuclear basket protein;translocated promoter region (to activated MET oncogene);nucleoprotein TPR;tumor potentiating region;nuclear pore complex-associated protein TPR
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TPR-95H |
Active Recombinant Human TPR, GST-tagged
|
Sf9 Cells | Human | GST | 1-191;399-end a.a. |
|
| TPR-30424TH | Recombinant Human TPR, His-tagged | E.coli | Human | His | 69-668 a.a. |
|
| TPR-6248R | Recombinant Rat TPR Protein | Mammalian Cells | Rat | His |
|
|
| TPR-1748T | Recombinant Trypanosoma Cruzi TPR Protein (1-492 aa), His-tagged | Yeast | Trypanosoma Cruzi | His | 1-492 aa |
|
| TPR-5905R | Recombinant Rat TPR Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
|
|
| TPR-5905R-B | Recombinant Rat TPR Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
Involved Pathway
TPR involved in several pathways and played different roles in them. We selected most pathways TPR participated on our site, such as RNA transport,Pathways in cancer,Thyroid cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | EIF4EA,EIF3BA,EIF2B2,SUMO3,FMR1,EEF1A1L2,RAE1,EIF4BA,PHAX,EIF3I |
| Thyroid cancer | LEF1,MAP2K1,RXRB,KRAS,TRP53,NTRK1,BRAF,RXRG,TP53,NRAS |
| Pathways in cancer | GSK3B,CKS2,WNT16,LAMA5,TP53,STAT5A,GNA11,EGLN1,FASLG,BRCA2 |
Protein Function
TPR has several biochemical functions, for example, chromatin binding,dynein complex binding,heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TPR itself. We selected most functions TPR had, and list some proteins which have the same functions with TPR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | ATXN7,BAHCC1,MAZ,SOD3,ESR1,GLI1,RERE,SMAD6,PRDM13,BRD3 |
| mRNA binding | LUC7L,EIF4A3,DHFRL1,HSP26,TDRD7,TSN,TRA2B,CALR,NANOS2,MECP2 |
| tubulin binding | TPPP3,CLIP1,STMN2B,STMN4,STMN1B,CENPJ,FYN,MTAP4,VBP1,TBCC |
| poly(A) RNA binding | RPSA,USP10,MATR3,PRPF38B,RPL30,NOSIP,GOT2,ABCF1,TUFM,ADK |
| nucleocytoplasmic transporter activity | NUP107,NUPL1,NUP133,NUP35,NUP214,XPO1,NUP153,TPRB,UPF3A,NUP160 |
| molecular_function | VMN1R163,VWC2,ZDBF2,CLMN,NLRP4C,PTTG2,SYNGR2A,C1QTNF3,ECRG4A,C21orf56 |
| protein homodimerization activity | MID2,Fzd4,GSS,RENBP,HM13,GHR,FGFR2,UGT1A6A,Flt3l,GOT2 |
| protein binding | RGS16,CHAMP1,C1QTNF3,CRYBB1,TRIM41,NOX1,MPP2,SNX5,MYLK2,SESN2 |
| dynein complex binding | HDAC6,CCDC155 |
Interacting Protein
TPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPR here. Most of them are supplied by our site. Hope this information will be useful for your research of TPR.
Mad2l1;MAD1L1;FOS;SMAD2;Tpr;Kifc1;TRAF6;APC;SF1;MAP3K4;midostaurin;Katna1;CBX7;FN1;VCAM1
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References
- Klein, JS; Jiang, SD; et al. Design and characterization of structured protein linkers with differing flexibilities. PROTEIN ENGINEERING DESIGN & SELECTION 27:325-330(2014).
- Mansiaux, Y; Carrat, F; et al. Detection of independent associations in a large epidemiologic dataset: a comparison of random forests, boosted regression trees, conventional and penalized logistic regression for identifying independent factors associated with H1N1pdm influenza infections. BMC MEDICAL RESEARCH METHODOLOGY 14:-(2014).
