TREX1
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Official Full Name
three prime repair exonuclease 1 -
Overview
This gene encodes the major 3->5 DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3 ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
TREX1;three prime repair exonuclease 1;AGS1, Aicardi Goutieres syndrome 1;DRN3;DNase III;3 repair exonuclease 1;3-5 exonuclease TREX1;CRV;AGS1;HERNS;DKFZp434J0310
Recombinant Proteins
- Mouse
- Human
- Mammalian Cells
- E.coli
- HEK293
- Baculovirus
- Insect Cells
- His
- Non
- Trx
- MBP
- Myc
- Avi
- Fc
Involved Pathway
TREX1 involved in several pathways and played different roles in them. We selected most pathways TREX1 participated on our site, such as Cytosolic DNA-sensing pathway,Cytosolic sensors of pathogen-associated DNA,IRF3-mediated induction of type I IFN, which may be useful for your reference. Also, other proteins which involved in the same pathway with TREX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immune System | NCKIPSD,LILRB4,ERAP2,IgG3,HBL3,IFI30,IRF9,KLRB1B,CHST13,SH3RF1 |
| Innate Immune System | ABI1B,POLR3G,PCBP2,DEFB129,CLEC5A,TLR10,NLRP4C,UNC93B1,MAP3K8,BFB |
| IRF3-mediated induction of type I IFN | NLRP4E,NLRP4C,DDX41,NLRP4B,NLRP4,IFI16 |
| STING mediated induction of host immune responses | NLRP4E,NLRP4C,NLRP4,MB21D1,NLRP4B,DDX41,IFI16 |
| Regulation of innate immune responses to cytosolic DNA | NLRP4,NLRP4E,NLRP4C,NLRP4B,DDX41,TRIM56 |
| Cytosolic sensors of pathogen-associated DNA | POLR3G,NLRP4,ALCAMB,AGER,CHST13,POLR3H,APPA,IFI16,APPB,NLRP4C |
| Cytosolic DNA-sensing pathway | POLR3E,POLR2K,LOC100033925,IFNPHI3,POLR2EB,CCL4,IFNA16,TBK1,IKBKB,MB21D1 |
Protein Function
TREX1 has several biochemical functions, for example, 3-5 exonuclease activity,3-5-exodeoxyribonuclease activity,MutLalpha complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TREX1 itself. We selected most functions TREX1 had, and list some proteins which have the same functions with TREX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | FBXO4,CAMK2A,PRKG2,HMOX1,XDH,MITD1,G6PD,ID1,PRDM6,HIF1AN |
| exodeoxyribonuclease III activity | RAD1,RAD9,RAD9A,TREX2 |
| MutLalpha complex binding | PCNA |
| 3-5 exonuclease activity | EXOSC10,REV3L,POLG,RAD1,RAD9,POLE,EXD2,APEX1,APLF,RAD9B |
| 3-5-exodeoxyribonuclease activity | POLD1,TREX2 |
| protein binding | MAB21L1,SOX14,RAP1GDS1,TPSAB1,COPRS,NR2E3,ITGB4,HCLS1,SPACA3,XPO7 |
| MutSalpha complex binding | MUTYH |
| single-stranded DNA binding | MCM7,RAD51C,MCM4,TSN,SETMAR,RPA4,CTC1,OBFC2B,ERCC5,IGHMBP2 |
| metal ion binding | CNOT6L,ZNF773,JMJD5,PRIM2,CYB561D1,BGLAP2,IMPDH2,FCN1,NT5C3L,ZBTB20 |
Interacting Protein
TREX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TREX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TREX1.
KRTAP10-7
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References
- Fanouriakis, A; Boumpas, DT; et al. Pathogenesis and treatment of CNS lupus. CURRENT OPINION IN RHEUMATOLOGY 25:577-583(2013).
- Terao, C; Ohmura, K; et al. Association Between Antinuclear Antibodies and the HLA Class II Locus and Heterogeneous Characteristics of Staining Patterns The Nagahama Study. ARTHRITIS & RHEUMATOLOGY 66:3395-3403(2014).
