Human TREX1 Knockdown Cell Lysate

• Cat.No.: TREX1-455HKCL
• Product Overview: WB-validated TREX1 Knockdown HeLa Cell Lysate

Specification

• Species: Human
• Source: HeLa
• Tag: Non
• Description: This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants.
• Form: Cell-Tissue Lysis buffer
• Molecular Mass: 33 kDa
• Notes: Instruction of use: This knockdown cell lysate should be paired with wild-type HeLa cell lysate for use. For Western blotting, we recommend running wild-type and knockdown lysates on the same gel, and loading each well with equal volume and equal amount of total proteins.
• Storage: Store at -20 centigrade for two years.
• Concentration: Lot-specific
• Shipping: Blue Ice
• Components: 1 vial of 100 μg WT HeLa cell lysate 1 vial of 100 μg TREX1 KD HeLa cell lysate
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytosolic DNA-sensing pathway
• Lysate QC: RT-qPCR; Western Blotting (WB)

Gene Information

• Gene Name: TREX1 three prime repair exonuclease 1 [ Homo sapiens (human) ]
• Official Symbol: TREX1
• Synonyms: TREX1; three prime repair exonuclease 1; AGS1, Aicardi Goutieres syndrome 1; DRN3; DNase III; 3 repair exonuclease 1; 3-5 exonuclease TREX1; CRV; AGS1; HERNS; DKFZp434J0310
• Gene ID: 11277
• mRNA Refseq: NM_016381
• Protein Refseq: NP_057465
• MIM: 606609
• UniProt ID: Q9NSU2