TRIO

  • Official Full Name

    TrioB6
  • Overview

    Triple functional domain protein is a protein that in humans is encoded by the TRIO gene. TRIO (gene) has been shown to interact with Filamin and RHOA.
  • Synonyms

    trio;0368/10;0959/14;1372/03;1386/06;BEST:LD36950;CG18214;CG9208;Dmel\CG18214;DTrio;l(3)036810;l(3)6D104;l(3)S036810;l(3)S095914;l(3)S137203;l(3)S138606;l(3)S[1372/3];l(3)S[1386/06];l(3)trio;M89;UNC-73/Trio;CG18214 gene product from transcript CG18214-RA;CG18214-PA;CG18214-PB;CG18214-PC;CG18214-PD;CG18214-PE;CG18214-PF;trio-PA;trio-PB;trio-PC;trio-PD;trio-PE;trio-PF
Cat.# Product name Source (Host) Species Tag Protein Length Price
TRIO-17404M Recombinant Mouse TRIO Protein Mammalian Cells Mouse His
TRIO-9628M Recombinant Mouse TRIO Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
TRIO-9628M-B Recombinant Mouse TRIO Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    TRIO involved in several pathways and played different roles in them. We selected most pathways TRIO participated on our site, such as Axon guidance,Cell death signalling via NRAGE, NRIF and NADE,DCC mediated attractive signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology EFNB3,EFNA2A,SREBF2,ARPC1B,MYL12A,AP2A1,ST8SIA2,MED31,MYL9,IL17RD
    G alpha (q) signalling events AGT,MGLL,AGTR1,PMCH,EDNRB,TRPC6A,PRKCHB,TRPC3,FFAR3,RGS21
    Axon guidance DNM1,PLXNA1,ACTR2,PSPN,PEA15A,GPC1B,EGF,DCC,RASGEF1A,SEMA4A
    Gastrin-CREB signalling pathway via PKC and MAPK ARHGEF25,OPN4B,LPAR2A,TAE1,TRH,UTS2,RASGRP2,PROKR1A,GPR68,PROK1
    Cell death signalling via NRAGE, NRIF and NADE ARHGEF9,FGD2,FGD4A,PLEKHG2,ARHGEF3,TIAM2,ARHGAP4,BCL2L11,ABR,AKAP13
    DCC mediated attractive signaling NTN1A,DCC,DOCK1,NTN1B
    G alpha (12/13) signalling events ITSN1,MCF2L,RHOGA,GNA13,RHOB,FGD4,PLEKHG2,ECT2,ADRA1D,ARHGEF1A
    GPCR downstream signaling RAMP2,OPN1MW,OPN1SW1,PYYA,MCF2L,PPY,ARHGAP4A,RXFP2B,GPR132,TAE1

    Protein Function

    TRIO has several biochemical functions, for example, ATP binding,Rho guanyl-nucleotide exchange factor activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIO itself. We selected most functions TRIO had, and list some proteins which have the same functions with TRIO. You can find most of the proteins on our site.

    Function Related Protein
    kinase activity AKT3A,TNIKA,CMPK,PI4KAP2,CKMT2A,AGPHD1,EPHB3A,NMRK2,PRKACAB,PTK2BB
    enzyme binding HIST1H2AG,HDHD2,UGT1A9,NOP14,CDK19,SRC,APP,TNKS2,RPS3,PYCARD
    nucleotide binding GNAO1A,PUF60A,ABCC8,ARL15A,EIF4A1B,PRTFDC1,CDK12,PTK2AA,ARL4CA,NAIP7
    protein kinase activity EGFRA,AKT3A,PRKACBB,CCL3,RAF1,GRK1,CSNK1E,TNK2B,MAK,NEK4
    transferase activity RAF1B,NDUFAF5,PRKCBP1L,B3GNTL1,UGT2B1,CDKN1D,ST6GAL2A,KITA,AANAT2,MCAT
    protein serine/threonine kinase activity BMP2K,BMPR1B,LATS1,NEK9,BMPR1A,MAP4K1,EIF2AK4,BCKDK,RIOK2,DYRK3
    guanyl-nucleotide exchange factor activity SBF1,EIF2B5,KALRN,RASGRF2B,ANKRD27,RAPGEF3,RAPGEF1B,VAV3,RABIF,FARP2
    ATP binding BTK,SYN3,CSNK1DA,AASDH,MYO1E,PRKAA1,ATP2B4,HSPD1,PINK1,TEC
    Rho guanyl-nucleotide exchange factor activity AKAP13,ARHGEF25,ALS2CL,ARHGEF1,ARHGEF40,BCR,VAV2,ARHGEF7A,RASGRF2,ARHGEF3L

    Interacting Protein

    TRIO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIO here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIO.

    Resources

    References

    • Bradshaw, NJ; Bader, V; et al. Aggregation of the Protein TRIOBP-1 and Its Potential Relevance to Schizophrenia. PLOS ONE 9:-(2014).
    • Marie, A; Holzmuller, P; et al. Anopheles gambiae salivary protein expression modulated by wild Plasmodium falciparum infection: highlighting of new antigenic peptides as candidates of An. gambiae bites. PARASITES & VECTORS 7:-(2014).

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