TRPC5

  • Official Full Name

    transient receptor potential cation channel, subfamily C, member 5

  • Overview

    This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1).

  • Synonyms

    TRPC5;transient receptor potential cation channel, subfamily C, member 5;short transient receptor potential channel 5;transient receptor protein 5;Trrp5
Cat.# Product name Source (Host) Species Tag Protein Length Price
TRPC5-742HCL Recombinant Human TRPC5 293 Cell Lysate HEK293 Human Non
RFL34046BF Recombinant Full Length Bovine Short Transient Receptor Potential Channel 5(Trpc5) Protein, His-Tagged E.coli Bovine His Full L. Full Length (1-109)
TRPC5-01H Recombinant Human TRPC5 Protein (A2-L973 end), N-8×His-MBP-TEV and C-Flag-tagged Mammalian Cells Human Flag&His&MBP A2-L973 end
TRPC5-1161HFL Recombinant Human TRPC5 protein, His&Flag-tagged HEK293 Human Flag&His 1-973 aa
TRPC5-1269H Recombinant Human TRPC5 Protein (A2-L973 end), 8×His-MBP, Flag tagged Mammalian Cells Human Flag&His&MBP A2-L973 end
TRPC5-4633H Recombinant Human TRPC5 protein, His-tagged E.coli Human His

    Involved Pathway

    TRPC5 involved in several pathways and played different roles in them. We selected most pathways TRPC5 participated on our site, such as Axon guidance,Developmental Biology,Ion channel transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ion channel transport UNC79,BEST1,TRPC4AP,TRPM4A,MCOLN2,ANO4,SRI,CLCA1,TRPM1,CLCNK
    TRP channels TRPA1A,TRPM1B,TRPC4B,TRPC5A,TRPC4APB,TRPC4AP,TRPC4,TRPM1,TRPA1B,TRPV3
    Axon guidance RNF8,PLXNA1,HBEGF,SPTA1,ARPC1A,COL4A4,PHB,KRAS,PSPN,SCN9A
    Developmental Biology STX1B,KIF4A,SCN3A,EFNA2,DUSP5,ITGB3A,AP2S1,DNM1,RND1L,CNTN6
    Transmembrane transport of small molecules ANKHB,SLC28A1,SLC6A20A,FXYD7,SLC34A2A,SLC5A3A,TRPC4APA,TRPM1A,ATP1A1A.4,TRPC4
    Netrin-1 signaling UNC5D,RGMB,PITPNA,RNF8,HFE2,RGMA,NTN1A,TRPC4,NTN1B,SIAH2
    Role of second messengers in netrin-1 signaling PITPNA,TRPC4
    Stimuli-sensing channels TRPA1B,ANO4,CLCN1,TRPM1,BEST4,TRPM1A,SCNN1D,TRPC5A,BSND,ANO7

    Protein Function

    TRPC5 has several biochemical functions, for example, calcium channel activity,inositol 1,4,5 trisphosphate binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPC5 itself. We selected most functions TRPC5 had, and list some proteins which have the same functions with TRPC5. You can find most of the proteins on our site.

    Function Related Protein
    calcium channel activity ORAI1B,CACNA1SB,TRPC4B,SLC24A4,ITPR1,SLC24A2,TRPC2,TRPN1,TRPV6,TRPC7B
    protein binding KIF13B,PSMA4,MCL1,FAP,ZNF302,ULK2,STAT5A,HES1,EPB41L1,PRKX
    inositol 1,4,5 trisphosphate binding TRPC2,CYTH2,TRPC4,TRPC5A,RPH3A,TRPC3,TRPC2B,ITPR3,AKR1C1,TRPC6A
    store-operated calcium channel activity TRPC6,ORAI2,ORAI3,TRPC1,TRPC7,STIM2,ZP3,TRPC6A,TRPC5A,TRPC2B

    Interacting Protein

    TRPC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPC5.

    MX1

    Resources

    References

    • Dong, YP; Pan, QX; et al. Tumor endothelial expression of P-glycoprotein upon microvesicular transfer of TrpC5 derived from adriamycin-resistant breast cancer cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 446:85-90(2014).
    • Tabarean, IV; et al. Persistent Histamine Excitation of Glutamatergic Preoptic Neurons. PLOS ONE 7:-(2012).

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