TRPC5
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Official Full Name
transient receptor potential cation channel, subfamily C, member 5 -
Overview
This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). -
Synonyms
TRPC5;transient receptor potential cation channel, subfamily C, member 5;short transient receptor potential channel 5;transient receptor protein 5;Trrp5
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRPC5-742HCL | Recombinant Human TRPC5 293 Cell Lysate | HEK293 | Human | Non |
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| RFL34046BF | Recombinant Full Length Bovine Short Transient Receptor Potential Channel 5(Trpc5) Protein, His-Tagged | E.coli | Bovine | His | Full L. Full Length (1-109) |
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| TRPC5-01H | Recombinant Human TRPC5 Protein (A2-L973 end), N-8×His-MBP-TEV and C-Flag-tagged | Mammalian Cells | Human | Flag&His&MBP | A2-L973 end |
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| TRPC5-1161HFL | Recombinant Human TRPC5 protein, His&Flag-tagged | HEK293 | Human | Flag&His | 1-973 aa |
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| TRPC5-1269H | Recombinant Human TRPC5 Protein (A2-L973 end), 8×His-MBP, Flag tagged | Mammalian Cells | Human | Flag&His&MBP | A2-L973 end |
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| TRPC5-4633H | Recombinant Human TRPC5 protein, His-tagged | E.coli | Human | His |
|
Involved Pathway
TRPC5 involved in several pathways and played different roles in them. We selected most pathways TRPC5 participated on our site, such as Axon guidance,Developmental Biology,Ion channel transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Netrin-1 signaling | EZRA,HFE2,SIAH2,NTN1B,RGMA,UNC5D,PITPNA,RNF8,NTN1A,TRPC4 |
| Ion channel transport | TRPM1B,ASIC1A,FXYD7,CLCN7,ANO5B,WNK2,SLC9A10,TRPM4C,ATP8B1,CLCN6 |
| Role of second messengers in netrin-1 signaling | TRPC4,PITPNA |
| Axon guidance | PITPNA,EFNA3,NRP1,RND1L,EPHA2,MYL12A,RGMB,MYL12B,AP2M1,ITSN1 |
| Transmembrane transport of small molecules | SLC1A2B,SLC5A6B,ANKHB,SLC15A3,SLC6A19B,ATP1A1A.5,SLC7A11,HTR3C,CLCN7,SLC28A2 |
| TRP channels | TRPC4APB,TRPC5A,MCOLN2,MCOLN3,TRPV3,TRPM1B,TRPA1B,TRPM4C,TRPC4AP,TRPC4 |
| Stimuli-sensing channels | CLCN7,WNK2,SGK2,ANO4,CLIC2,TRPA1A,TRDN,ANO10A,TPCN1,TRPC4B |
| Developmental Biology | MED6,DPYSL5A,GDNF,FRS3,CLTA,ACTR3,ARHGEF28,ARPC5,KALRNB,CTNNA2 |
Protein Function
TRPC5 has several biochemical functions, for example, calcium channel activity,inositol 1,4,5 trisphosphate binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPC5 itself. We selected most functions TRPC5 had, and list some proteins which have the same functions with TRPC5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium channel activity | TRPC4B,MCU,TRPC7A,CCDC109A,ORAI1B,CACNG8A,P2RX1,SLC24A2,TPCN1,GRIN2A |
| store-operated calcium channel activity | TRPC2B,ORAI3,TRPC5A,TRPC1,ZP3,TRPC7,ORAI1B,STIM2,TRPC7A,ORAI1 |
| inositol 1,4,5 trisphosphate binding | ITPR3,TRPC7,TRPC7A,TRPC5A,PLCL1,CYTH2,AKR1C1,TRPC6A,TRPC2B,TRPC1 |
| protein binding | NIPBL,RAPGEF4,POC1A,CUL9,MEF2A,FBXL14,RIN3,GATA1A,MAD1L1,RAC1 |
Interacting Protein
TRPC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPC5.
MX1
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References
- Dong, YP; Pan, QX; et al. Tumor endothelial expression of P-glycoprotein upon microvesicular transfer of TrpC5 derived from adriamycin-resistant breast cancer cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 446:85-90(2014).
- Tabarean, IV; et al. Persistent Histamine Excitation of Glutamatergic Preoptic Neurons. PLOS ONE 7:-(2012).
