TYMP
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Official Full Name
thymidine phosphorylase
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Overview
This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012] -
Synonyms
TYMP; thymidine phosphorylase; TP; ECGF; ECGF1; MNGIE; MEDPS1; MTDPS1; PDECGF; hPD-ECGF; tdRPase; gliostatin;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- TYMP Related Articles
- TYMP Related Research Area
TYMP involved in several pathways and played different roles in them. We selected most pathways TYMP participated on our site, such as Bladder cancer, Drug metabolism - other enzymes, Fluoropyrimidine Activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with TYMP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bladder cancer | MMP1A;DAPK3;DAPK1;TRP53;IL-8;HRAS;VEGFA;TYMP;RAF1 |
| Drug metabolism - other enzymes | TK2;TPMT.1;NAT2;CES1D;UGT1A9;UGT2A3;UGT1A7C;GMPS;UCK1 |
| Fluoropyrimidine Activity | UPP2;SLC22A7;TYMP;DPYD;DPYS;CES1;DHFR |
| Metabolic pathways | AGK;AK7B;CKMT2B;UGT2A1;GLULB;MTR;ATP5G3A;GLUL;DGKZ |
| Metabolism | DCT;NDUFA11;CYB5R3;ARSJ;MED9;ACOT11B;SLC35B2;CKMT1B;B4GALT7 |
| Metabolism of nucleotides | UPP2;NUDT5;GRX2;DPYS;TM9SF1;ADK;NUDT16;DPYD;DTYMK |
| Pyrimidine catabolism | DPYD;TYMP;DPYS;PROZA;UPP2;DPYDA.1 |
| Pyrimidine metabolism | UMPS;ENTPD6;ENTPD5;POLR2F;CMPK1;ENTPD8;POLR2I;POLD1;NT5C1A |
TYMP has several biochemical functions, for example, growth factor activity, phosphorylase activity, platelet-derived growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TYMP itself. We selected most functions TYMP had, and list some proteins which have the same functions with TYMP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | IL34;AREG;PSPN;HBEGFB;FGF12;INHBA;FGF17;MSTNA;FGF8B |
| phosphorylase activity | PYGMB;TYMP;PYGMA;MTAP |
| platelet-derived growth factor receptor binding | PDGFC;PDGFD;PDGFAA;LYN;PDGFB;PDGFRA;PDGFRB;PTPRJ;ITGB3 |
| pyrimidine-nucleoside phosphorylase activity | |
| thymidine phosphorylase activity | |
| transferase activity, transferring pentosyl groups | TYMP;PNP5B;PNP4A;PNP6 |
TYMP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TYMP here. Most of them are supplied by our site. Hope this information will be useful for your research of TYMP.
Cdk1
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