U2AF2

  • Official Full Name

    U2 small nuclear RNA auxiliary factor 2

  • Overview

    U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]

  • Synonyms

    U2AF2;U2 small nuclear RNA auxiliary factor 2;U2AF65;splicing factor U2AF 65 kDa subunit;hU2AF65;U2 auxiliary factor 65 kDa subunit;U2 snRNP auxiliary factor large subunit;U2 (RNU2) small nuclear RNA auxiliary factor 2;U2 small nuclear ribonucleoprotein auxiliary factor (65kD)
Cat.# Product name Source (Host) Species Tag Protein Length Price
U2AF2-3513H Recombinant Human U2AF2 protein, GST-tagged E.coli Human GST 116-471 aa
U2AF2-17682M Recombinant Mouse U2AF2 Protein Mammalian Cells Mouse His
U2AF2-718HCL Recombinant Human U2AF2 lysate HEK293 Human Non
U2AF2-13H Recombinant Human U2AF2 Protein (141 a.a.-240 a.a.), N-GST-tagged Wheat Germ Human GST 141-240
U2AF2-9806M Recombinant Mouse U2AF2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
U2AF2-9806M-B Recombinant Mouse U2AF2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    U2AF2 involved in several pathways and played different roles in them. We selected most pathways U2AF2 participated on our site, such as Cleavage of Growing Transcript in the Termination Region,Gene Expression,Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with U2AF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gene Expression ZNF671,ZNF713,CSTF3,NR2E1,ZNF256,LSM6,ZFP37,SKIA,RXRBB,TAF1A
    Cleavage of Growing Transcript in the Termination Region NUDT21,CSTF3,LSM11,CSTF2,SLBP,SRSF11,PAPOLA,LSM10,ZFP473,CSTF1
    Transport of Mature Transcript to Cytoplasm SLBP,NXF1,SFRS3A,SRSF11
    RNA Polymerase II Transcription Termination SLBP,CSTF3,CLP1,NUDT21,ZNF473,CSTF1,ZFP473,THOC4,PAPOLA,LSM10
    RNA Polymerase II Transcription NUDT21,SUPT16H,CSTF1,THOC4,CCNT2A,PAPOLA,CCNT2B,CSTF3,ZNF473,SSRP1A
    Transport of Mature mRNA derived from an Intron-Containing Transcript SFRS3A,SRSF11
    Processing of Capped Intron-Containing Pre-mRNA METTL14,HNRNPA0L,HNRNPA0A,SF3A3,BCAS2,CSTF3,ZCRB1,NUDT21,SUGP1,SF3B4
    Spliceosome HNRNPM,PRP19,TCERG1A,BCAS2,SNRPD2,SRSF7A,HSPA1A,NHP2L1,U2AF2B,SF3B2

    Protein Function

    U2AF2 has several biochemical functions, for example, C2H2 zinc finger domain binding,enzyme binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by U2AF2 itself. We selected most functions U2AF2 had, and list some proteins which have the same functions with U2AF2. You can find most of the proteins on our site.

    Function Related Protein
    poly(A) RNA binding SRPR,DCD,PRMT1,ASS1,SYF2,YBX1,NOP56,ZFP106,RPL27A,UBE2I
    pre-mRNA 3-splice site binding ZRSR2,SLU7
    nucleotide binding CDC6,RHOAC,BMPR2B,RAB18B,RALY,APLF,SRSF9,RND3A,ULK1A,RBMS3
    C2H2 zinc finger domain binding TAF9,EHMT1,THAP7,LEF1,WT1,HMGA2,EHMT2,GATA2,ZXDC,GATA1
    protein binding MID1,PHB,LYRM2,FHIT,AP1B1,GSE1,ZNF398,ADRA2C,SPON1,FAM90A1
    poly-pyrimidine tract binding PTBP1,CPEB2
    enzyme binding PUS7,PRKCA,SCN5A,BCR,SORT1,HLCS,ESR1,RCOR1,RCOR2,PARP4

    Interacting Protein

    U2AF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with U2AF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of U2AF2.

    U2AF1;PUF60;SF1

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